The widespread availability of vitamin D-containing

The gap

Evidence profile

Sourced from the limitations and inline gaps and stated challenges and future-work section of the source papers, classified as general, spanning 7 journals.

Supporting evidence — 7 representative gaps

• Functional and Symptomatic Effects of Vitamin D Supplementation Following Carpal Tunnel Release: A Randomized Controlled Trial (2026) · Journal of Southeast Asian Orthopaedics · doi

  This study had several limitations. First, serum vitamin D levels were not measured before or after treatment, which precludes analysis of whether baseline deficiency or achieved serum concentrations influenced the outcomes. However, epidemiological studies in Thailand and other Asian populations have shown that vitamin D insufficiency common, particularly among urban residents and women, thus providing a clinical context for evaluating vitamin D supplementation. However, the absence of biochemical assessments remains an important limitation. relatively remains Second, the 12-week follow-up period may not have been sufficient to capture longer-term motor recovery or the potential delayed benefits of supplementation. Third, the relatively small sample size may have limited the statistical power to detect subtle intergroup differences.

  generallimitationsevidence 5/5
  Keywords: vitamin serum supplementation remains relatively several limitations first levels measured treatment precludes whether baseline deficiency
• Prevalence of Hypovitaminosis D Among Patients With Type 2 Diabetes Mellitus: Evidence From a Diabetes Clinic in Durgapur, West Bengal (2026) · Cureus · doi

  The use of multivariable logistic regression enabled adjustment for potential confounders and the identification of independent predictors of hypovitaminosis D. However, because this was a hospital-based cross-sectional study, the findings may not be fully generalizable to the broader community. The relatively high absolute error (10%) used in sample size calculation resulted in a modest sample size. Berksonian bias may also have influenced the findings. Additionally, the cross-sectional design precludes causal inference regarding the relationship between vitamin D status and microvascular complications. Biochemical markers such as parathyroid hormone, serum calcium, phosphate, and inflammatory markers were not assessed, which limits mechanistic interpretation. Further multicentric studies with larger sample sizes are recommended to improve external validity and confirm these findings.

  generallimitationsevidence 5/5
  Keywords: sample cross sectional size markers multivariable logistic regression enabled adjustment potential confounders identification independent predictors
• Relationship Between Serum Vitamin D Levels and Clinical Findings: What We Know and Unknown in Pediatric Cases (2026) · Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi · doi

  The main limitation of this study is its retrospective design. Additionally, by checking the hospital information system or pharmacy information system, the possibility of RRIs in the patient should be investigated. Furthermore, due to the observational nature of the study, causal relationships between vitamin D levels and the evaluated symptoms and clinical findings could not be established.

  generalinline gapsevidence 5/5
  Keywords: information system main limitation retrospective design additionally checking hospital pharmacy possibility rris patient investigated observational
• Intervention methods and influencing factors of vitamin D deficiency in Northeast China: a self-controlled trial and randomized controlled trial study (2026) · Frontiers in Nutrition · doi

  From a precise nutrition perspective, children with different SNP genotypes and different dietary vitamin D intakes differ in their sensitivity to vitamin D supplementation, warranting further research on genotype-specific vitamin D requirements. a for Third, are only although these genetic-related differences foundation for preliminary further research on precise nutrition for children living in high-latitude regions.

  generalinline gapsevidence 5/5
  Keywords: vitamin precise nutrition children erent further perspective genotypes dietary intakes sensitivity supplementation warranting genotype speci
• Hypervitaminosis D: an underestimated complication of supplementation (2026) · Health Problems of Civilization · doi

  The widespread availability of vitamin D-containing preparations, combined with insufficient patient awareness of the potential consequences of excessive intake. The inadequate quality control of dietary supplements, in which substantial discrepancies have been identified between the actual and declared vitamin D content. The need for regular monitoring of therapy to prevent hypervitaminosis D.

  generalstated challengesevidence 5/5
  Keywords: widespread availability vitamin d-containing preparations combined insufficient patient
• Vitamin D deficiency in elderly people in Ecuador (2026) · The Journal of Latin American Geriatric Medicine · doi

  Further studies should be conducted to confirm the findings and establish the prevalence of vitamin D deficiency in other populations. Research should focus on developing effective interventions for improving vitamin D levels in older adults. Studies should investigate the relationship between vitamin D levels and health outcomes in older adults. The impact of educational campaigns on vitamin D levels should be evaluated.

  generalfuture-work sectionevidence 5/5
  Keywords: further studies conducted confirm findings establish prevalence vitamin
• Associations of Vitamin D Receptor (ApaI, FokI, TaqI, BsmI) Polymorphisms with Neurodegenerative Diseases in the Middle East, North Africa and Turkiye (MENA&T) Region: A Systematic Review and Meta-Analysis Toward Population-Specific Precision Medicine (2026) · Journal of Personalized Medicine · doi

  The influence of geography, lifestyle, and cultural practices on vitamin D status varies, making it a potential factor in neurodegenerative diseases. The study of VDR polymorphisms and neurodegenerative diseases is complex due to the multifactorial aetiologies of the diseases. The lack of comprehensive synthesis of evidence on the association between VDR polymorphisms and neurodegenerative diseases in the region is a challenge.

  generalstated challengesevidence 5/5
  Keywords: influence geography lifestyle cultural practices vitamin status varies

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