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Open research questions in Economic and Financial Impacts of Cancer

117 gap statements mined from Economic and Financial Impacts of Cancer papers in our 4.5M-paper local library, which holds 913 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The paper identifies logistical barriers, such as lack of transportation and difficulty communicating with providers, as challenges in cancer care. It highlights the importance of addressing language barriers and low health literacy. The paper emphasizes the need for a diverse oncology workforce to provide culturally competent care.

    From Diagnosis to Survivorship: The Role of Social Determinants in Cancer Care · 2025 · DOI

  • The lack of studies focusing on adjuvant and neoadjuvant treatment. The limited number of studies using Markov models and partitioned survival models.

    The Cost of Breast Cancer: Economic and Social Perspective · 2025 · DOI

  • The research highlights the need to address the economic burden of cancer care. The study notes the importance of considering the complex interplay between costs of care and patients' psychological and behavioral responses to the financial burdens of treatment.

    The Role of Social Support in Buffering the Financial Toxicity of Breast Cancer: A Qualitative Study of Patient Experiences · 2025 · DOI

  • Few investigations focus on protective factors that safeguard against financial toxicity. There is a need to explore how social support might reduce financial toxicity among patients with breast cancer who are at high risk for financial hardship.

    The Role of Social Support in Buffering the Financial Toxicity of Breast Cancer: A Qualitative Study of Patient Experiences · 2025 · DOI

  • The aim was to test whether the Canadian model could be replicated or a SEI‐based model fit better.

    Toward a validated European instrument to measure the socioeconomic impact of cancer · 2026 · DOI

  • Additional patient-centric financial navigation and price transparency are warranted to mitigate financial burden.

    Modeling the Arc of Financial Well-Being in Breast Reconstruction: A Mixed-Methods Study · 2026 · DOI

  • Distal upper extremity nerve injuries are a substantial cause of disability with socioeconomic consequences, yet their personal financial impact remains poorly understood.

    Personal Financial Burden after Distal Upper Extremity Nerve Injury · 2026 · DOI

  • Higher OOP cost burden was associated with cost-related care avoidance regardless of cancer history, but cost burden alone was insufficient for risk identification.

    Comparing the association between out‐of‐pocket cost burden and cost‐related care avoidance among individuals with and without a history of cancer · 2026 · DOI

  • Changes in medical costs for melanoma patients have not yet been examined in Japan.

    Analysis of Medical Costs of Melanoma Using a Japanese National Database · 2026 · DOI

  • Routine screening and targeted interventions are warranted for all cancer survivors, with even greater focus on financially burdened GI cancer survivors.

    Distinct financial and social hardships among gastrointestinal cancer survivors: a national survey analysis · 2026 · DOI

  • Despite increasing efforts to address financial toxicity among patients with cancer, approaches to best identify patients for targeted intervention remain unclear.

    Demystifying financial toxicity measures: semi-structured interviews comparing COST-FACIT and ENRICh among cancer survivors on targeted oral anticancer medications (TOAMs) · 2026 · DOI

  • Out-of-pocket (OOP) costs and healthcare utilization remain unknown for women facing breast conservation and mastectomy.

    Patient Out‐of‐Pocket Costs and Healthcare Utilization Related to Mastectomy vs Breast Conservation: A Claims‐Based Study · 2026 · DOI

  • Importance: Affordable access to surgical procedures remains elusive for many in the US.

    Financial Hardship After Surgical Procedures · 2025 · DOI

  • However, the financial hardship attributable to surgical procedures is not well understood at the national level.

    Financial Hardship After Surgical Procedures · 2025 · DOI

  • Little is known about the role that charitable copay assistance (CPA) plays in addressing access to care and financial distress.

    National survey of financial burden and experience among patients with cancer and autoimmune disease receiving charitable copay assistance · 2025 · DOI

  • The financial burden of cancer care may significantly impair patients' health-related quality of life (HRQoL), yet the extent and nature of this relationship remain underexplored, particularly in low-resource settings.

    Association between out-of-pocket expenditure and health-related quality of life among patients receiving cancer treatment: a cross-sectional study from Nepal · 2025 · DOI

  • Evidence on the impact of shared decision-making (SDM) on the financial toxicity (FT) of patients with cancer in real clinical settings is lacking.

    Association of shared decision-making with financial toxicity and coping actions in adult patients with cancer: a nationwide study in China · 2024 · DOI

  • Therapeutic advances have improved MBC survival rates but patient expressed needs such as time and financial toxicity have not been evaluated in Ireland to date.

    247P Financial and time burden associated with living with a metastatic breast cancer (MBC) diagnosis in Ireland: An all-Ireland patient-led survey (CTRIAL-IE 23-05) · 2024 · DOI

  • Little is known about financial toxicity in early-phase clinical trial (EP-CT) participants.

    Financial toxicity in early‐phase cancer clinical trial participants · 2024 · DOI

  • However, little is known about the associations of HRSNs and mortality risk among adult cancer survivors.

    Health‐related social needs, medical financial hardship, and mortality risk among cancer survivors · 2024 · DOI

  • Sociodemographic, clinical, and area-level factors may mediate this relationship; however, no studies have assessed the extent to which these factors contribute to the racial/ethnic disparities in financial hardship.

    Understanding racial differences in financial hardship among older adults surviving cancer · 2024 · DOI

  • Efforts to increase cost-of-care discussions and relevant referrals, as well as their documentation, are warranted.

    Cost‐of‐care discussions for individuals with advanced non–small cell lung cancer and melanoma: Findings from a large, population‐based pilot study · 2024 · DOI

  • Few studies have examined how these costs prospectively influence treatment decision-making.

    Advanced cancer treatment decisions and their patient-facing financial burdens: a thematic analysis · 2026 · DOI

  • Ongoing research on the direct impact of clinical cancer outcomes, - Research on the impact of bias on cancer care, - Studies on the effect of diverse oncology teams on health…

    From Diagnosis to Survivorship: The Role of Social Determinants in Cancer Care · 2025 · DOI

  • Evaluating indirect costs of breast cancer. Further research on adjuvant and neoadjuvant treatment. Research on the cost-effectiveness of specific combinations of drugs.

    The Cost of Breast Cancer: Economic and Social Perspective · 2025 · DOI

Most-cited papers in Economic and Financial Impacts of Cancer

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Open questions raised by papers listed on this page include: (1) Additional patient-centric financial navigation and price transparency are warranted to mitigate financial burden (“Modeling the Arc of Financial Well-Being in Breast Reconstruction: A…”, 2026); (2) Distal upper extremity nerve injuries are a substantial cause of disability with socioeconomic consequences, yet their personal financial impact remains poorly understood (“Personal Financial Burden after Distal Upper Extremity Nerve Injury”, 2026); (3) Changes in medical costs for melanoma patients have not yet been examined in Japan (“Analysis of Medical Costs of Melanoma Using a Japanese National Database”, 2026); (4) Routine screening and targeted interventions are warranted for all cancer survivors, with even greater focus on financially burdened GI cancer survivors (“Distinct financial and social hardships among gastrointestinal cancer…”, 2026); (5) Despite increasing efforts to address financial toxicity among patients with cancer, approaches to best identify patients for targeted intervention remain unclear (“Demystifying financial toxicity measures: semi-structured interviews comparing…”, 2026). 117 gap statements have been mined from Economic and Financial Impacts of Cancer papers in our 4.5M-paper local library, which holds 913 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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