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Open research questions in Helminth infection and control

84 gap statements mined from Helminth infection and control papers in our 4.5M-paper local library, which holds 652 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Legislative measures to restrict over-the-counter access to veterinary medications not FDA-approved for human use, such as fenbendazole, should be explored to prevent continued misuse.

    Drug-Induced Liver Injury Following Co-ingestion of Veterinary Fenbendazole and Ivermectin for Prostate Cancer: A Case Report · 2026 · DOI

  • The lack of studies on the economic viability and quantified losses of parasitoses in family farming systems. The limited understanding of the effectiveness and economic viability of agroecological control alternatives.

    PARASITOSES GASTRINTESTINAIS EM PEQUENOS RUMINANTES DA AGRICULTURA FAMILIAR NO BRASIL: PERDAS PRODUTIVAS, IMPACTO ECONÔMICO E ALTERNATIVAS AGROECOLÓGICAS DE CONTROLE · 2026 · DOI

  • Furthermore, the strong binding affinity of scFvFgSAP2 to SAP2 suggests its potential as a diagnostic agent, a concept that has not been extensively explored in previous research on fasciolosis.

    Production and Characterization of Recombinant Single-Chain Variable Fragment (scFv) Antibody Against Fasciola gigantica Saposin-like Protein 2 · 2026 · DOI

  • The immune response mechanism of the host against Eustrongylides tubifex parasite is unclear. There is a lack of understanding of the transcriptomic changes in domestic ducks infected with Eustrongylides tubifex.

    Transcriptomic Analysis of Domestic Ducks’ Proventriculus Infected with Eustrongylides tubifex (Nitzsch 1819) Jägerskiöld 1909 · 2026 · DOI

  • There is a need for studies on the prevalence of gastrointestinal parasites in horses in different regions. There is a need for studies on the influence of gastrointestinal parasites on hematological and biochemical parameters.

    Haematobiochemical Changes in Gastrointestinal Parasites-Infected Horses in Al Jabal Al Akdar, Libya · 2026 · DOI

  • There is a need to investigate the prevalence and epidemiological distribution of gastrointestinal parasites among equines in Nigeria. The study aims to fill the knowledge gap on the most prevalent parasites and their distribution among different age groups, breeds, and locations.

    Prevalence and Epidemiological Distribution of Gastrointestinal Parasites in Equines from Selected Stables in Nigeria · 2026 · DOI

  • There is a lack of epidemiological data regarding gastrointestinal parasites in horses in Côte d’Ivoire. There is a need to investigate the prevalence and diversity of gastrointestinal parasites in horses in the district of Abidjan.

    Prevalence of gastrointestinal parasites in horses in the district of Abidjan, Ivory Coast · 2026 · DOI

  • There is limited information on gastrointestinal parasites in Malaysian wild boars. The study addresses the gap in knowledge on the prevalence and diversity of gastrointestinal parasites in wild boars from indigenous community settlements.

    Gastrointestinal Parasites in Wild Boars from an Indigenous Community Settlement in Sarikei, Sarawak · 2026 · DOI

  • Another limitation of the present study is the absence of quantitative immunohistochemical scoring or molecular cytokine profiling, which would be valuable for correlating inflammatory mediator expression with lesion severity and fungal burden.

    Immunohistochemical localization of tumor necrosis factor-α in gastrointestinal tissues of budgerigars naturally infected with Macrorhabdus ornithogaster · 2026 · DOI

  • There is a lack of information on the prevalence and morphological characteristics of Balantidium sp. in frogs. There is a need for new antiprotozoal agents effective against Balantidium spp.

    Morphological characterization and in vitro evaluation of Dendronephthya sp. extract against Balantidium sp. infecting Amietophrynus kassasii in New Valley Governorate, Egypt · 2026 · DOI

  • Future molecular analyses using PCR and gene sequencing are necessary to confirm parasite identity and improve taxonomic accuracy. In addition, the relatively small sample size represents another limitation of the present investigation.

    Morphological characterization and in vitro evaluation of Dendronephthya sp. extract against Balantidium sp. infecting Amietophrynus kassasii in New Valley Governorate, Egypt · 2026 · DOI

  • The disease can be extremely dangerous and even fatal for humans. Current treatments have limitations, such as poor efficacy against encapsulated larvae. There is a need for alternative treatments.

    Comparison of albendazole, chloroquine, and Allium sativum for treating Trichinella spiralis at distinct infection stages: an experimental study · 2026 · DOI

  • There is a need for alternative treatments for T. spiralis due to the limitations of current treatments. There is a lack of studies evaluating the effectiveness of chloroquine and Allium sativum in treating T. spiralis.

    Comparison of albendazole, chloroquine, and Allium sativum for treating Trichinella spiralis at distinct infection stages: an experimental study · 2026 · DOI

  • There is a need to understand the mechanisms underlying gastric lesions in domestic pigs and wild boars. The interplay of diet, stress, microbiota, and infection pressure in the development of gastric lesions is not fully understood.

    Gastric Lesions in Domestic Pigs and Wild Boars: Etiology, Pathology and Predisposing Factors · 2026 · DOI

  • There is a need to determine the prevalence of liver trematodes in sheep and goats in the Siirt province. The infection rates of Fasciola spp. and D. dendriticum in sheep and goats in the Siirt province are not well understood.

    Prevalence of Liver Trematodes in Sheep and Goats Slaughtered in the Siirt Province Slaughterhouse · 2026 · DOI

  • More detailed research on roe deer acquisition of and infestation by T. hydatigena is needed. Further studies on the definitive hosts of the parasite are required.

    Cysticercus tenuicollis in selected locations in Poland: genetic diversity, prevalence and epidemiological patterns in roe deer (Capreolus capreolus) and moose (Alces alces) · 2026 · DOI

  • There is a need for studies on the occurrence and treatment of Parascaris spp. related surgical intestinal lesions in Scandinavia. There is a need for studies on the short-term survival rates after laparotomy in affected foals and yearlings.

    Parascaris spp. induced surgical colic in juvenile horses—A Scandinavian perspective · 2026 · DOI

  • Enteric pathogens are a significant concern in the goat industry, causing gastrointestinal disorders and economic losses. The detection of enteric pathogens in goats is challenging due to the lack of sensitive and specific diagnostic methods. The study of enteric pathogens in goats requires a comprehensive approach, including molecular diagnostic methods and epidemiological analysis.

    Prevalence and distribution of enteric pathogens detected in slaughtered goats in Jeonbuk Province, Korea · 2026 · DOI

  • Prior studies have relied on farm-level fecal sampling and focused on limited pathogens. There is a lack of baseline epidemiological data for surveillance and public health purposes.

    Prevalence and distribution of enteric pathogens detected in slaughtered goats in Jeonbuk Province, Korea · 2026 · DOI

  • The study had a limited sample size of 225 participants. The study was conducted in only one state in Nigeria. The study relied on self-reported data from the respondents.

    Knowledge, Attitude and Practice of Fascioliasis in Abattoirs: Implication for Public Health in Osun State, Nigeria · 2026 · DOI

  • There is a lack of awareness and knowledge about fascioliasis among butchers and meat sellers. Preventive practices against fascioliasis are inadequate. There is a need for strengthened education and training programs.

    Knowledge, Attitude and Practice of Fascioliasis in Abattoirs: Implication for Public Health in Osun State, Nigeria · 2026 · DOI

  • Chicory (Cichorium intybus, Puna II) has emerged as a promising antiparasitic forage, yet its broader effects on the equine holobiont, parasites, microbiota, and host physiology remain poorly understood.

    Nutritional Anthelmintics: Chicory Reconfigures the Equine Holobiont Across Microbial, Parasitic, and Host Scales · 2026 · DOI

  • Data regarding the interactions of eprinomectin with foods or vitamin supplements that may affect intestinal absorption remain limited. The effects of vitamins A and E on the transepithelial permeability of eprinomectin are not well understood.

    Effects of vitamins A and E on eprinomectin transport in Caco-2 cells · 2026 · DOI

  • Revista Brasileira de Zootecnia, Viçosa, v. 48, e20180016, 2019.

    PARASITOSES GASTRINTESTINAIS EM PEQUENOS RUMINANTES DA AGRICULTURA FAMILIAR NO BRASIL: PERDAS PRODUTIVAS, IMPACTO ECONÔMICO E ALTERNATIVAS AGROECOLÓGICAS DE CONTROLE · 2026 · DOI

  • In vivo studies to investigate the effects of VA and VE on EPR permeability - Mechanistic studies to clarify the underlying pathways of VA and VE on EPR…

    Effects of vitamins A and E on eprinomectin transport in Caco-2 cells · 2026 · DOI

Most-cited papers in Helminth infection and control

Most recent work

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Open questions raised by papers listed on this page include: (1) The lack of studies on the economic viability and quantified losses of parasitoses in family farming systems (“PARASITOSES GASTRINTESTINAIS EM PEQUENOS RUMINANTES DA AGRICULTURA FAMILIAR NO…”, 2026); (2) The immune response mechanism of the host against Eustrongylides tubifex parasite is unclear (“Transcriptomic Analysis of Domestic Ducks’ Proventriculus Infected with…”, 2026); (3) There is a need for studies on the prevalence of gastrointestinal parasites in horses in different regions (“Haematobiochemical Changes in Gastrointestinal Parasites-Infected Horses in Al…”, 2026); (4) There is a need to investigate the prevalence and epidemiological distribution of gastrointestinal parasites among equines in Nigeria (“Prevalence and Epidemiological Distribution of Gastrointestinal Parasites in…”, 2026); (5) There is a lack of epidemiological data regarding gastrointestinal parasites in horses in Côte d’Ivoire (“Prevalence of gastrointestinal parasites in horses in the district of Abidjan,…”, 2026). 84 gap statements have been mined from Helminth infection and control papers in our 4.5M-paper local library, which holds 652 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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