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Open research questions in Psoriasis: Treatment and Pathogenesis

696 gap statements mined from Psoriasis: Treatment and Pathogenesis papers in our 7.9M-paper local library, which holds 2,960 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The lack of understanding of the pathophysiological mechanisms linking psoriasis and depression. The need for alternative interventions for individuals with psoriasis and comorbid depression. The limited efficacy of current therapeutic regimens in mitigating depressive symptoms in psoriasis patients.

    Huaiqihuang Alleviates Imiquimod-Induced Psoriasis-Like Skin Lesions and Depressive-Like Behaviors in Mice · 2026 · DOI

  • The available therapies for psoriasis have limitations, highlighting the need for safer and more affordable alternatives. There is a need for therapeutic alternatives that can be administered over long periods.

    Evaluation of the therapeutic potential of Iraqi Anagyris foetida L. leaf extracts in imiquimod-induced psoriasis-like skin lesions in mice · 2026 · DOI

  • One challenge is the complexity of psoriasis pathogenesis, involving multiple immune cells and cytokines. Another challenge is the lack of understanding of the therapeutic effects of Zhuhuang Granules on psoriasis. A third challenge is the need for alternative therapeutic strategies with improved efficacy and safety.

    Zhuhuang Granules alleviate psoriatic inflammation via restoring gut microbiota balance and enhancing intestinal barrier integrity · 2026 · DOI

  • The study needs to validate the predicted mechanisms via clinical specimen analysis and in vitro cell experiments. The study requires the integration of multiple approaches, including network pharmacology, molecular docking, and clinical analysis.

    Network pharmacology-based investigation of the therapeutic effects and molecular mechanisms of oxymatrine in psoriasis · 2026 · DOI

  • Whether machine learning adds value beyond baseline severity in telepharmacy-monitored psoriasis is unclear. Whether the first follow-up sharpens risk estimation in telepharmacy-monitored psoriasis is unclear.

    Longitudinal DLQI trajectory patterns and early risk updating in telepharmacy-monitored psoriasis · 2026 · DOI

  • Current topical therapies for psoriasis have limitations, such as long-term side effects. There is a demand for safer alternatives. The mechanisms of psoriasis and the effects of DH-YH on psoriasis-like skin inflammation are not fully understood.

    A four-herb topical formula attenuates psoriasis-like skin inflammation by suppressing IL-17-mediated inflammation and pathogenic γδT17 cell infiltration · 2026 · DOI

  • The need for further research to elucidate the underlying mechanisms of the relationships between psoriasis and other skin diseases.

    Psoriasis in the Context of Dermatologic Disorders: A Comprehensive Overview · 2025 · DOI

  • Less attention has been given to the coexistence of psoriasis with other dermatoses. The underlying mechanisms of the relationships between psoriasis and other skin diseases are not fully understood.

    Psoriasis in the Context of Dermatologic Disorders: A Comprehensive Overview · 2025 · DOI

  • The underlying pathways that link psoriasis to metabolic syndrome are complex and not fully understood. The role of gut microbiota in the pathogenesis of metabolic syndrome needs to be further elucidated.

    Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota · 2024 · DOI

  • Although biologics targeting these cytokines have transformed therapy, the transcriptional contributions of individual skin-resident cell types remain unclear, and dermal fibroblasts have been largely overlooked compared with keratinocytes.

    Dermal Fibroblasts, Not Keratinocytes, Dominate IL‐17A/TNF‐Driven Inflammation · 2026 · DOI

  • Clinically, psoriasis tends to worsen or relapse in winter, but the underlying mechanisms remain unclear.

    Cold Stress Activates ACSL1 + Macrophages in a Fatty Acid‐Dependent Manner to Exacerbate Psoriasis · 2026 · DOI

  • Enhancer of Zeste Homologue 2 (EZH2) is an epigenetic regulator involved in immune cell differentiation and function; however, its role in psoriasis remains unknown.

    Reduced EZH2 Expression in Circulating CD8 ‐Positive T Cells and Monocytes in Psoriasis · 2026 · DOI

  • Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and environmental pollutant, has been implicated in the exacerbation of psoriasis, although the underlying molecular mechanisms remain unclear.

    Benzo[ a ]pyrene Aggravates Psoriasis‐Like Skin Inflammation via Circulating Exosomal microRNA Modulation · 2026 · DOI

  • The potential role of the immunogen double-stranded (ds)DNA as a trigger of and biomarker for psoriasis warrants exploration.

    Serum DSDNA is Associated With Psoriasis · 2026 · DOI

  • SKH-1 mice, which lack functional hair follicles and display a thickened epidermis that more closely resembles human skin than that of C57BL/6 mice, represent a potential psoriasis model, but their suitability remains uncertain.

    Comparative Transcriptomics Reveals SKH ‐1 Mice as a Valuable Model for Psoriasis Pathogenesis and Recurrence Studies · 2026 · DOI

  • Calcium-binding protein 39 (CAB39), a critical regulatory scaffold for Sterile 20 kinase, has been implicated in multiple diseases, but its role and regulatory mechanisms in psoriasis remain unclear.

    CAB39 K196 Decrotonylation Drives Psoriasis Pathogenesis by Modulating Keratinocyte Proliferation and Glycolysis · 2026 · DOI

  • While skin immune cells maintain homeostasis and defense, the impact of obesity on these cells in intact skin is understudied, as research mainly focuses on skin with an inflammatory skin disease model in the context of obesity.

    High Fat Diet‐Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss · 2026 · DOI

  • Psoriasis is a chronic inflammatory skin disease involving abnormal keratinocyte gene expression, yet the upstream epigenetic mechanisms driving these alterations remain unclear.

    FOSL1-associated condensates modulate superenhancer-mediated selected IL-1 family gene activation in psoriasis · 2026 · DOI

  • These findings indicate that insulin resistance is the strongest independently associated factor of endothelial dysfunction in psoriasis, with systemic inflammation contributing additional explanatory value; however, the strong overlap between disease severity and circulating TNF-α prevents definitive separation of their individual effects, and formal mediation analyses in larger cohorts are warranted.

    Endothelial Dysfunction in Psoriasis: A Comparative Analysis of Cutaneous, Inflammatory, and Metabolic Correlates · 2026 · DOI

  • Data regarding dose de-escalation, in particular D-S, on IL-23, are lacking to date.

    Dose Modulation Strategies in Psoriatic Patients: Real‐Life Pilot Comparison Between Risankizumab and Guselkumab up to 12 Months After Dose Spacing · 2025 · DOI

  • A higher prevalence of hyperuricemia is observed in psoriasis, yet the precise involvement of hyperuricemia in psoriasis remains unclear.

    Hyperuricemia Exacerbates Psoriatic Inflammation by Inducing M1 Macrophage Activation and Th1 Cell Differentiation · 2025 · DOI

  • The current-medication field was available for only about one third of patients and the treatment-line field was almost entirely missing. Age at smoking initiation, diagnosis date, treatment line and medication-level fields were not used in the primary models because of high missingness or limited reliability. The study was a retrospective secondary analysis.

    Longitudinal DLQI trajectory patterns and early risk updating in telepharmacy-monitored psoriasis · 2026 · DOI

  • Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts > 500 nucleotides with diverse regulatory functions; their role in epidermal dysfunction in psoriasis is poorly understood.

    RNA Sequencing Reveals the Long Non‐Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non‐Coding RNA Regulating Epidermal Differentiation · 2025 · DOI

  • Further phytochemical characterization to identify the major bioactive constituents of Anagyris foetida leaf extracts. Investigation of the therapeutic potential of Anagyris foetida leaf extracts in human psoriasis patients. Comparison of the efficacy of Anagyris foetida leaf extracts with other available therapies for psoriasis.

    Evaluation of the therapeutic potential of Iraqi Anagyris foetida L. leaf extracts in imiquimod-induced psoriasis-like skin lesions in mice · 2026 · DOI

  • Long-term corticosteroid use can lead to skin atrophy and tachyphylaxis, - Biologics are limited by high costs and risks of serious infection, - The study used a small sample size of 5 mice per…

    A four-herb topical formula attenuates psoriasis-like skin inflammation by suppressing IL-17-mediated inflammation and pathogenic γδT17 cell infiltration · 2026 · DOI

Most-cited papers in Psoriasis: Treatment and Pathogenesis

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Open questions raised by papers listed on this page include: (1) The lack of understanding of the pathophysiological mechanisms linking psoriasis and depression (“Huaiqihuang Alleviates Imiquimod-Induced Psoriasis-Like Skin Lesions and…”, 2026); (2) There is a need for therapeutic alternatives that can be administered over long periods (“Evaluation of the therapeutic potential of Iraqi Anagyris foetida L. leaf…”, 2026); (3) Another challenge is the lack of understanding of the therapeutic effects of Zhuhuang Granules on psoriasis (“Zhuhuang Granules alleviate psoriatic inflammation via restoring gut microbiota…”, 2026); (4) Whether machine learning adds value beyond baseline severity in telepharmacy-monitored psoriasis is unclear (“Longitudinal DLQI trajectory patterns and early risk updating in…”, 2026); (5) The mechanisms of psoriasis and the effects of DH-YH on psoriasis-like skin inflammation are not fully understood (“A four-herb topical formula attenuates psoriasis-like skin inflammation by…”, 2026). 696 gap statements have been mined from Psoriasis: Treatment and Pathogenesis papers in our 7.9M-paper local library, which holds 2,960 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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