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Open research questions in Psoriasis: Treatment and Pathogenesis

239 unresolved questions extracted from the limitations and future-work sections of 623 Psoriasis: Treatment and Pathogenesis papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The complexity of psoriasis pathogenesis and the need for comprehensive patient-reported outcome assessments. The challenge of achieving sustained remission in patients with moderate-to-severe plaque psoriasis. The need for effective treatments that address both disease severity and quality of life.

    Multidimensional efficacy characterization of xeligekimab in moderate-to-severe plaque psoriasis: regional responses, treatment targets, and patient-reported outcomes from a randomized controlled trial · 2026 · DOI

  • Limited availability of clinical records and follow-up information. No prespecified study protocol dictated paediatric dosing. No systematic posttreatment laboratory monitoring was available for all patients.

    Short-course vunakizumab associated with rapid improvement of acute flares in paediatric generalised pustular psoriasis: a three-patient case series · 2026 · DOI

  • Further studies are needed to confirm the efficacy and safety of vunakizumab in paediatric GPP, - Larger sample sizes are required to draw more definitive conclusions

    Short-course vunakizumab associated with rapid improvement of acute flares in paediatric generalised pustular psoriasis: a three-patient case series · 2026 · DOI

  • Chronic inflammation is a key underlying mechanism in various gynecological and obstetrics-related diseases. The complexity of the IL-1 family and its signaling pathways poses a challenge to understanding the role of IL-37. The lack of understanding of the mechanisms by which IL-37 exerts its anti-inflammatory effects is a challenge.

    Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review) · 2026 · DOI

  • The pathogenesis of polyendocrine metabolic ovarian syndrome remains incompletely understood. The role of IL-37 in gynecological and obstetrics-related diseases is not fully understood. The mechanisms by which IL-37 exerts its anti-inflammatory effects are not fully elucidated.

    Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review) · 2026 · DOI

  • The complexity of psoriatic disease, with its interplay of genetic, immunological, and metabolic factors, poses a significant challenge. The need for longitudinal studies to determine whether expansion of CD8+CCR10+ T cells precedes the clinical onset of psoriatic arthritis is a challenge. The development of robust predictive models that can identify patients at high risk of psoriatic arthritis development is a challenge.

    The immunometabolic tipping point: forecasting the systemic shift from psoriasis to psoriatic arthritis · 2026 · DOI

  • individual biomarkers often lack sufficient predictive power, - polygenic risk scores currently lack sufficient discriminatory power for clinical use, - the ability to predict which patients will develop articular disease remains limited

    The immunometabolic tipping point: forecasting the systemic shift from psoriasis to psoriatic arthritis · 2026 · DOI

  • The precise etiology of psoriasis remains uncertain. There is a need to handle missing data and confounding factors in the analysis. The study required the use of advanced modeling techniques to integrate multiple data sources.

    Dynamic trend analysis of global psoriasis burden from 1990 to 2021: a study of gender, age, and regional differences based on GBD 2021 data · 2025 · DOI

  • Further research is needed to understand the factors contributing to the increasing burden of psoriasis, - Studies should investigate the relationship between SDI and psoriasis burden in more detail, - Research should focus on developing effective public health strategies to address the increasing burden of psoriasis

    Dynamic trend analysis of global psoriasis burden from 1990 to 2021: a study of gender, age, and regional differences based on GBD 2021 data · 2025 · DOI

  • Comparable data on recruitment rates for dermatology registries are limited. Registry-based studies are subject to selection bias.

    Assessing representation in a nation-wide psoriasis registry: a single-institution comparison · 2026 · DOI

  • CD4+ cytotoxic T lymphocytes (CD4-CTLs) are understudied immune mediators with ambiguous origins.

    IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage · 2026 · DOI

  • Population-based data on the epidemiology of GPP examining ethnic and sex differences, and life-expectancy, remain scarce.

    Incidence, prevalence, and life expectancy of patients with generalised pustular psoriasis in England: a population-based cohort study exploring ethnic and sex variations · 2026 · DOI

  • However, their role in chronically inflamed skin-particularly in terms of phenotypic and functional diversity-remains poorly understood.

    Low-density neutrophils preferentially infiltrate the skin compared to conventional neutrophils in an experimental psoriasis model · 2026 · DOI

  • However, the clinical characteristics and predictors of CVD in psoriasis patients remain incompletely understood.

    Clinical characteristics and influencing factors of cardiovascular comorbidities in psoriasis · 2025 · DOI

  • However, the specific role of the IL-37a isoform in hepatocellular carcinoma (HCC) development remains poorly understood.

    Metabolic reprogramming of liver-resident NK Cells by IL-37a promotes hepatocellular carcinoma progression 2940 · 2025 · DOI

  • Although the pre-clinical trials of IL-21-based cancer immunotherapy have been encouraging, the precise effect of IL-21 on anti-tumor responses remains incompletely understood.

    An IL-21-derived neokine with enhanced anti-tumor efficacy 2594 · 2025 · DOI

  • , with a 7-10% fatality rate in the US and limited knowledge of its pathobiology.

    Interleukin-27 orchestrates lymphocyte responses and disease severity during Legionella infection in the lung 2083 · 2025 · DOI

  • Abstract Description Obesity potently alters immune responses across a range of inflammatory contexts, but the effects of a short-term obesogenic diet, independent of significant weight gain, on immune function are not well understood.

    Diet on disease onset is a critical modifier of inflammatory disease trajectory 4530 · 2025 · DOI

  • The effects of this treatment on skin microorganisms and microbiome-encoded metabolic pathways remain unclear.

    IL-17A inhibitors modulate skin microbiome in psoriasis: implications for microbial homeostasis · 2025 · DOI

  • In particular, the influence of body size and metabolic parameters on disease severity and treatment response is underexplored.

    Association of BMI, BMR, BSA, and body weight with psoriasis severity and treatment response: evidence from a real-world cohort · 2025 · DOI

  • The literature on the DR of the newest generation of biologics (IL-17/23i) was scarce.

    Dose reduction of biologics in patients with plaque psoriasis: a review · 2024 · DOI

  • The identified barriers against the implementation of DR were mainly a lack of guidelines and scientific evidence on effectiveness and safety, and a lack of time and (technical) support.

    Dose reduction of biologics in patients with plaque psoriasis: a review · 2024 · DOI

  • However, the impact of being overweight on this relationship remains underexplored.

    Associations between body mass index and all-cause mortality among individuals with psoriasis: results from the NHANES database retrospective cohort study · 2024 · DOI

  • Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear.

    p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production · 2024 · DOI

  • Indeed, this process is not limited to the inflammatory response but also plays a role in the adaptive immune response.

    The IL-23R and Its Genetic Variants: A Hitherto Unforeseen Bridge Between the Immune System and Cancer Development · 2024 · DOI

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239 open questions have been extracted from the limitations and future-work passages of 623 Psoriasis: Treatment and Pathogenesis papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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