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Open research questions in Schizophrenia research and treatment

962 unresolved questions extracted from the limitations and future-work sections of 5,242 Schizophrenia research and treatment papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The lack of a Japanese version of an international mental health-specific QOL instrument. The need for a valid and reliable QOL instrument for people with severe mental illness in Japan. The gap in knowledge about the relationships between QOL domains and psychiatric diagnosis in the Japanese population.

    Development of the Japanese version of the Manchester short assessment of quality of life (MANSA) among people with self-reported severe mental illness · 2026 · DOI

  • Future mechanistic research on FTD is suggested. Future interventional research on FTD is suggested. Large-scale clinical use of short-form instruments like the Thought and Language Index is proposed.

    The functional relevance of a short assessment of formal thought disorder in psychosis · 2026 · DOI

  • The lack of a reliable and efficient method to assess formal thought disorder (FTD). The uncertainty in understanding the latent dimensions and network structure of FTD.

    The functional relevance of a short assessment of formal thought disorder in psychosis · 2026 · DOI

  • Diluted attention to preventive care due to lack of dedicated funding and integration with EIP services. Complexity of clinical high-risk assessments requiring extensive training and administration time. Need for efficient detection strategies and quick referral to EIP services to reduce the duration of untreated psychosis.

    Can critical components of effective early intervention in psychosis also advance early detection and preventive care for young people at risk? · 2026 · DOI

  • No validated biomarkers to facilitate prevention in the CHR-P phase, - Complexity of CHR-P assessments, - Limited standalone CHR-P services

    Can critical components of effective early intervention in psychosis also advance early detection and preventive care for young people at risk? · 2026 · DOI

  • The study was not preregistered and a protocol was not published. There was no external validation of the models. The sample size was limited, with 172 individuals in the baseline model development sample and 97 individuals in the 12-week model development sample. No power calculation for the prediction models was performed.

    Antipsychotic-induced weight gain in psychosis: causal mediation analysis and feasibility study of causal actionable prediction model development using counterfactuals to target obesity · 2026 · DOI

  • Current models are not fully actionable for individuals. There is a need for a causal actionable prediction pathway to prevent antipsychotic-induced obesity.

    Antipsychotic-induced weight gain in psychosis: causal mediation analysis and feasibility study of causal actionable prediction model development using counterfactuals to target obesity · 2026 · DOI

  • There is a need for a predictive model that can identify patients with first-episode psychosis who are unlikely to achieve early clinical recovery. Current predictive models have limited generalisability and do not improve prediction.

    Predicting early clinical recovery in first-episode psychosis: development and external validation of a clinically interpretable multivariable model · 2026 · DOI

  • delivering adequately powered platform and adaptive trials, - investment in data quality and analytic capacity to support efficient screening and follow-up

    New approaches to clinical research for people with schizophrenia · 2026 · DOI

  • The neglect of clinical research for the most underserved patients with schizophrenia. The lack of representative recruitment and multidomain assessment in traditional clinical trials. The need for sustained funding to support clinical research in schizophrenia.

    New approaches to clinical research for people with schizophrenia · 2026 · DOI

  • further investigation into the mechanisms underlying the age-dependent gradient in schizophrenia incidence, - examination of the effects of sociodemographic factors on schizophrenia incidence and prevalence, - analysis of the impact of interventions on reducing the burden of schizophrenia among adolescents and young adults

    Trends in Burden of Schizophrenia among Adolescents and Young Adults: A Global Analysis from 1990 to 2021 · 2026 · DOI

  • The formal diagnosis of schizophrenia is usually conducted in late adolescence and early adulthood, but recent studies suggest that atypical brain structures related to schizophrenia may exist at earlier preadolescent age. There is a need to investigate structural brain differences between children with schizophrenia and healthy controls. There is a need to examine sex differences in children with schizophrenia.

    Cortical Structures Underlying Schizophrenia and Sex Differences in Preadolescents: An Adolescent Brain Cognitive Development Study · 2026 · DOI

  • The available evidence base is limited by the concentration of studies in high-income countries. The transferability of the evidence to settings with different resource levels, service structures, and sociocultural determinants of care is potentially limited. There is a need for more research on ACT implementation in diverse settings.

    Assertive Community Treatment and ACT-Derived Outreach Models: A Scoping Review of Adaptations, Fidelity and Outcomes · 2026 · DOI

  • The study faced challenges in terms of small sample size and lack of randomization. The study had to accommodate participants' individual clinical schedules, which may have affected the post-intervention assessment. The study had to minimize practice effects in the Trail Making Test-Japanese version.

    Effects of the Japanese Version of Metacognitive Training on Self-Efficacy and Sense of Coherence in Community-Dwelling Patients with Schizophrenia: A Pilot Study · 2026 · DOI

  • further studies with larger sample sizes and randomized controlled trial designs, - investigations into the long-term effects of MCT-J, - research into the mechanisms underlying the observed benefits of MCT-J

    Effects of the Japanese Version of Metacognitive Training on Self-Efficacy and Sense of Coherence in Community-Dwelling Patients with Schizophrenia: A Pilot Study · 2026 · DOI

  • The review did not include a Risk of Bias Assessment and Certainty of Evidence recommendations, - The review was limited to high-income countries, - The review was a rapid scoping review, which may not have captured all relevant studies

    Implementing Community-Based Psychosocial Interventions for Adults with Severe Mental Illness in High-Income Countries: A Rapid Scoping Review · 2026 · DOI

  • Further research is needed to develop and evaluate interventions that address the complex needs of individuals with SMI, - Research should focus on developing integrated care models and culturally responsive approaches, - Economic evaluations of psychosocial interventions are needed

    Implementing Community-Based Psychosocial Interventions for Adults with Severe Mental Illness in High-Income Countries: A Rapid Scoping Review · 2026 · DOI

  • Scarcity of resources, including financial/economic resources and human resources. Lack of personnel, especially psychotherapists, within public services. Difficulty in implementing family-centered practices and maintaining an adequate and suitable setting for psychotherapy in the workplace.

    Early Intervention in Psychosis: Perceptions, Strengths, Criticalities, and Improvement Proposals from the Perspective of Italian Mental Healthcare Professionals · 2026 · DOI

  • investigating the effectiveness of extending the EIP paradigm to those services previously excluded from EIP specialist training, - examining the impact of improvements in services' integration on patient outcomes, - exploring the relationship between scarcity of resources and patient outcomes

    Early Intervention in Psychosis: Perceptions, Strengths, Criticalities, and Improvement Proposals from the Perspective of Italian Mental Healthcare Professionals · 2026 · DOI

  • Logistical barriers to the implementation of point-of-care fingerstick testing, such as the need for substantial administrative and financial support. Patient preferences and perceptions of fingerstick testing, including concerns about pain and convenience. The need to integrate patient and clinic staff perspectives to understand the adoption of fingerstick testing.

    Implementing Point-of-Care Fingerstick Testing for Clozapine Safety Monitoring in Outpatient Psychiatry: A Convergent Mixed Methods Study · 2026 · DOI

  • The study had a limited sample size, - The study was conducted in only two clinics, - The study relied on self-reported data from patients, - The study did not include a control group, - The study was limited to patients with schizophrenia spectrum disorder

    Implementing Point-of-Care Fingerstick Testing for Clozapine Safety Monitoring in Outpatient Psychiatry: A Convergent Mixed Methods Study · 2026 · DOI

  • The extensive set of indicators needed to be reduced to ensure feasibility for practical implementation. The study required a balance between theoretical soundness and practical applicability.

    Ensuring High Quality Oyster Care for People Experiencing Severe and Persistent Mental Illness – A Three-Phase Development of A Quality Monitoring Tool · 2026 · DOI

  • The existing evidence on Oyster Care and palliative psychiatry in severe and persistent mental illness is limited. There is a need for a tool to support the consistent implementation of the Oyster Care model.

    Ensuring High Quality Oyster Care for People Experiencing Severe and Persistent Mental Illness – A Three-Phase Development of A Quality Monitoring Tool · 2026 · DOI

  • Investigating the relationship between model-brain alignment and symptoms in schizophrenia, - Examining the effects of auditory verbal hallucinations on encoding alignment, - Developing clinically actionable biomarkers for schizophrenia, - Replicating the study with a larger sample size

    Neural encoding of auditory processing in schizophrenia · 2026 · DOI

  • Clinical-population encoding work remains rare, with most research focusing on neurotypical adults. There is a need to understand how schizophrenia disrupts auditory processing and how this disruption relates to symptoms. The present work addresses this gap by applying voxelwise brain encoding models to a clinical population.

    Neural encoding of auditory processing in schizophrenia · 2026 · DOI

Most-cited papers in Schizophrenia research and treatment

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962 open questions have been extracted from the limitations and future-work passages of 5,242 Schizophrenia research and treatment papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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