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Open research questions in Selenium in Biological Systems

126 unresolved questions extracted from the limitations and future-work sections of 516 Selenium in Biological Systems papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • longitudinal studies to confirm causality, - investigations into the effects of selenium intake on other health outcomes, - studies to determine the optimal range of selenium intake for different populations

    A cross-sectional analysis of dietary selenium intake and type 2 diabetes risk in adults: insights from NHANES 2011–2016 · 2025 · DOI

  • The relationship between selenium and type 2 diabetes risk remains controversial. Prior studies have reported conflicting findings on the association between selenium and type 2 diabetes risk. There is a need to investigate the relationship between dietary selenium intake and type 2 diabetes risk in a nationally representative population.

    A cross-sectional analysis of dietary selenium intake and type 2 diabetes risk in adults: insights from NHANES 2011–2016 · 2025 · DOI

  • exploring strategies to activate the synergistic effect of Se-enriched microorganisms (SeMs), - investigating the potential of SeNPs as a promising source of selenium in various fields, - developing novel functional selenium forms like SeNPs

    Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review · 2025 · DOI

  • the lack of specific pharmacological interventions or well-established treatments for MASLD, - the need for accurate assessment of selenium nutritional status in MASLD patients, - the complex pathological mechanisms involved in MASLD

    Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Critical Review · 2025 · DOI

  • The heterogeneity of the available literature, particularly in the pediatric field, makes direct comparisons difficult. The geographical variability in selenium content in soil and food sources complicates the assessment of selenium adequacy. The lack of standardized protocols for literature selection and data synthesis in narrative reviews may introduce selection bias and limit the generalizability of conclusions.

    Thyroid Health and Selenium: The Critical Role of Adequate Intake from Fetal Development to Adolescence · 2025 · DOI

  • further research, - integrated public health strategies, ranging from sustainable, food-based approaches to targeted clinical screening and educational programs

    Thyroid Health and Selenium: The Critical Role of Adequate Intake from Fetal Development to Adolescence · 2025 · DOI

  • soil salinization poses a critical threat to global agricultural production - the abundance of genes encoding nonspecific selenate/selenite reductases makes it challenging to establish a direct biochemical pathway - the currently limited characterization of enzymes involved in both the methylation and oxidation pathways of selenium is a challenge

    Harnessing the Rhizosphere Microbiome for Selenium Biofortification in Plants: Mechanisms, Applications and Future Perspectives · 2025 · DOI

  • Elucidating the diverse enzymatic mechanisms underlying microbial oxidation of selenium, - Prioritizing the remediation of selenium pollution and biofortification strategies, - Investigating the effects of soil salinization on global agricultural production and ecosystem health

    Harnessing the Rhizosphere Microbiome for Selenium Biofortification in Plants: Mechanisms, Applications and Future Perspectives · 2025 · DOI

  • Future studies should investigate the relationship between Se intake and T2DM using a longitudinal design - Future studies should measure serum Se levels to assess bioavailability - Future studies should control for other factors that may influence Se bioavailability, such as genetics and food matrix

    Selenium intake and risk of type 2 diabetes among adults in Saudi Arabia · 2025 · DOI

  • The relationship between selenium intake and type 2 diabetes is not well understood. Prior studies have demonstrated mixed findings regarding the intake of selenium and the risk of type 2 diabetes. There is a need for further research to understand the relationship between selenium intake and glucose metabolism.

    Selenium intake and risk of type 2 diabetes among adults in Saudi Arabia · 2025 · DOI

  • The effects of selenium on mollusks remain insufficiently explored. There is a need to understand the molecular impact of selenium on oysters.

    Metabolic Alterations in Crassostrea Gigas After Feeding Selenium-Enriched Yeast Based on Transcriptomic Analysis · 2025 · DOI

  • Although selenium (Se) can alleviate the effects of salinity in many crops, its role in sesame remains unclear.

    The application of selenium enhances salt stress tolerance of sesame plants through regulation of key metabolic responses · 2026 · DOI

  • Selenium, a trace nutrient with nutritional and nutraceutical functions, is limited by a narrow optimal intake range.

    Selenium Nanoparticles Driving Innovations across the Food Chain: Applications in Food Systems, Feed Supplementation, and Sustainable Agriculture · 2026 · DOI

  • However, the nutritional regulatory mechanisms and physiological effects of L-SeMet in monogastric herbivores, particularly horses during mid- to late gestation, remain inadequately understood.

    Effects of L-selenomethionine supplementation on nutrient digestibility and metabolism, antioxidant capacity, hormone levels, and fecal microbiota diversity in pregnant Yili mares during mid- to late gestation · 2026 · DOI

  • 8 mg Se mare⁻¹ day⁻¹ appearing to confer the broadest benefits; dose optimization and long term outcomes warrant further investigation.

    Effects of L-selenomethionine supplementation on nutrient digestibility and metabolism, antioxidant capacity, hormone levels, and fecal microbiota diversity in pregnant Yili mares during mid- to late gestation · 2026 · DOI

  • Selenoprotein T (SELENOT) is a key regulator of cellular redox homeostasis that has not been fully characterized in skeletal muscles.

    Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation · 2025 · DOI

  • Selenium is an essential trace element that maintains muscle integrity; however, the mechanisms linking Se deficiency to muscle injury remain unclear.

    Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation · 2025 · DOI

  • However, there are few studies on the effects of nano-selenium fertilizer on potato scab caused by Streptomyces spp.

    Nano-selenium strengthens potato resistance to potato scab induced by Streptomyces spp., increases yield, and elevates tuber quality by influencing rhizosphere microbiomes · 2025 · DOI

  • However, concerns persist regarding potential health risks associated with NPs exposure, and importantly, the mechanisms of uptake, translocation and transformation of Se NPs in plants remain incompletely understood.

    Fate and Physiological Effects of Foliar Selenium Nanoparticles in Wheat · 2025 · DOI

  • While genome-wide analyses of the APK and APR families have been conducted across various plant species, a systematic identification and analysis of these gene families in Cardamine hupingshanensis is still lacking.

    Genome-wide identification, molecular docking and expression analysis of enzymes involved in the primary and secondary metabolic branching points of the selenium metabolic pathway in Cardamine hupingshanensis · 2025 · DOI

  • However, limited research has been done on organic selenium nanoparticles (Se-NPs).

    Comparative Effects of Capsicum annuum-Derived Selenium Nanoparticles and Sodium Selenite on Reproductive Performance, Egg Quality, and Male Sexual Behavior in Japanese Quails · 2025 · DOI

  • The thioredoxin system's role in Se hyperaccumulators is poorly understood. There is a lack of genome-wide identification of the thioredoxin system in Cardamine hupingshanensis.

    Genome-Wide Thioredoxin System in Cardamine hupingshanensis: Role in Se Stress and Metabolism · 2025 · DOI

  • Several studies indicated that selenium deficiency is associated with sarcopenia; however, the specific mechanism remains unclear.

    Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system · 2024 · DOI

  • BACKGROUND: The association between dietary selenium(Se) intake and type 2 diabetes mellitus (T2DM) remains controversial.

    Impact of age, sex, and thyroid autoimmunity on the association between selenium intake and type 2 diabetes mellitus · 2024 · DOI

  • Our results should be validated in future large prospective studies in different populations.

    Impact of age, sex, and thyroid autoimmunity on the association between selenium intake and type 2 diabetes mellitus · 2024 · DOI

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126 open questions have been extracted from the limitations and future-work passages of 516 Selenium in Biological Systems papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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