At the same time, the evidence base remains limited

The gap

Evidence profile

Stated in the discussion and limitations and cells limitations sections of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 3 representative gaps

• Physical Activity as a Modulator of Epicardial Adipose Tissue Dysfunction and Adipokine Profile in Obesity: Cardioprotective Mechanisms and Clinical Implications. A Literature Review (2026) · Quality in Sport · doi

  At the same time, the evidence base remains limited by the short duration of follow-up, small sample sizes, lack of standardization of EAT assessment, and the scarcity of interventional studies in patients at the highest cardiovascular risk, as well as by the absence of long-term data on the impact, of EAT reduction on hard clinical endpoints [7,10,12,13,20,21,22].

  generalstated in discussionevidence 5/5
  Keywords: time evidence base remains limited short duration follow small sample sizes lack standardization assessment scarcity
• Association between dietary inflammatory potential and chronic kidney disease among patients at Korle-Bu Teaching Hospital, Ghana (2026) · Scientific Reports · doi

  ￿ The use of non-probability sampling may limit generalizability and introduce selection bias. Retrieving the participants food history via the FFQ, could introduce recall bias as some of the participants might face difficulties providing accurate reflections of their meals. ￿ Additionally, there is the possibility that members of the case cohort have had prior exposure to diet therapies which could influence both their current meal intake and responses to present a “healthier” intake. These biases could be addressed in further studies through the use of alternative dietary intake assessment methods that are less subjective.

  generalstated in limitationsevidence 5/5
  Keywords: intake introduce bias participants probability sampling limit generalizability selection retrieving food history recall face difficulties
• Methodological challenges in translating nutrition evidence into the Australian Dietary Guidelines (2026) · British Journal of Nutrition · doi

  The crudeness and imprecision of the NOVA classification system may limit accurate assessment of ultra-processed food-related health outcomes. - The heterogeneity in dietary intake across countries may limit the applicability of evidence from different contexts to dietary guidelines targeting a specific context. - The paper highlights the need for high-quality, context-specific research to inform recommendations, implying that current evidence may be limited.

  generalstated in cells limitationsevidence 5/5
  Keywords: crudeness imprecision nova classification system limit accurate assessment

Questions about this gap