Conventional approaches may not fully capture

The gap

Evidence profile

Sourced from the future work and stated research gap of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 3 representative gaps

• Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management (2026) · Frontiers in Reproductive Health · doi

  Drug repurposing strategies Based on transcriptome-drug feature matching, alreadyapproved drugs such as genistein, pioglitazone, and alprostadil are predicted to improve endometrial function, although clinical validation is pending (39). 6.6.2 Induced pluripotent stem cells (iPSCs) Differentiation into oocyte-like cells has been achieved in animal models, but remains at the preclinical stage (105, 106). 6.6.3 Personalized treatment selection Individualization of endometrial preparation based on patient characteristics has been proposed as a strategy to optimize reproductive outcomes (107). Precision therapy based on dysbiotic, inflammatory, or mixed endometrial dysfunction) represents a future direction, although rapid point-of-care testing tools are currently lacking (42).

  generalfuture workevidence 5/5
  Keywords: endometrial based drug cells repurposing strategies transcriptome feature matching already approved drugs genistein pioglitazone alprostadil
• ENDOMETRIAL RECEPTIVITY: MOLECULAR MECHANISMS, THIN ENDOMETRIUM SUBTYPES, AND MECHANISM-BASED THERAPEUTIC APPROACHES (2026) · Kocaeli Üniversitesi Sağlık Bilimleri Dergisi · doi

  Advancing the field of endometrial receptivity requires a shift from morphology-based assessment toward molecularly defined, phenotype-oriented diagnostic frameworks. Future research should focus on identifying and validating standardized, clinically applicable molecular signatures capable of distinguishing functional from non-functional endometrium, independent of endometrial thickness. High-resolution single-cell approaches transcriptomics, spatial proteomics, and metabolomic profiling are expected to refine mechanistic subtyping and reveal actionable therapeutic targets. In parallel, well- designed prospective and multicenter clinical trials are needed to evaluate pathway-specific interventions, including regenerative, immune-targeted, and metabolic strategies, within clearly defined biological phenotypes.

  generalfuture workevidence 5/5
  Keywords: endometrial defined functional advancing field receptivity requires shift morphology based assessment toward molecularly phenotype oriented
• Integrating artificial intelligence and multi-omics data for precision oncology in endometrial cancer: a narrative review (2026) · Functional & Integrative Genomics · doi

  Conventional approaches may not fully capture the biological heterogeneity of endometrial cancer. The need for improved diagnostic, prognostic, and therapeutic decision-making frameworks remains. The integration of molecular, imaging, histopathological, and computational perspectives is necessary to enhance precision oncology.

  generalstated research gapevidence 5/5
  Keywords: conventional approaches fully capture biological heterogeneity endometrial cancer

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