Exploring the scope of the ion–π catalysis strategy for other transformations

The gap

Evidence profile

Sourced from the abstract and future-work section and limitations section and stated research gap of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 6 journals. Those papers have been cited 3 times in total.

Supporting evidence — 6 representative gaps

• Chirality-Matched Cyclopropenimine–Thiourea Organocatalysis for Regiocontrolled Ring-Opening Polymerization of Methyl Glycolide (2026) · ACS Catalysis · doi

  Chirality-matching strategies based on enantiopure monomers and chiral catalysts have been pursued in both organometallic catalytic and organocatalytic systems; however, the presence of metal residues remains a significant limitation, whereas organocatalytic approaches still lack a fundamental mechanistic understanding of site selectivity and fail to achieve a unified control over reaction conditions, rates, and regioselectivity.

  generalabstractevidence 5/5
  Keywords: organocatalytic chirality matching strategies based enantiopure monomers chiral catalysts pursued organometallic catalytic systems presence metal
• Chiral Cages With Asymmetric π‐Clefts Enable Catalytic Enantioconvergent S N 1 Transformation via Synergistic Cation–π and Anion–π Interactions (2026) · Angewandte Chemie International Edition · doi

  Exploring the scope of the ion–π catalysis strategy for other transformations. Investigating the applicability of chiral cages to different reaction types. Further elucidating the mechanisms of cation–π and anion–π interactions in catalysis.

  generalfuture-work sectionevidence 5/5
  Keywords: exploring scope ion catalysis strategy other transformations investigating
• Dynamic palladium catalysis enables chiral amplification toward acyclic Schiff base atropisomers (2026) · Nature Communications · doi

  the efficient synthesis of acyclic chiral Schiff base derivatives remains underdeveloped - imine's strong metal chelation may attenuate catalytic activity - enantioselectivity could not be improved beyond 60% enantiomeric excess (ee) with organocatalyzed asymmetric allylic substitution

  generallimitations sectionevidence 5/5
  Keywords: efficient synthesis acyclic chiral schiff base derivatives remains
• Catalytically Four‐Fold Asymmetric Sonogashira Coupling for Enantioselective Synthesis of Tetra‐functionalized Planar Chiral Pillar[5]arenes † (2025) · Chinese Journal of Chemistry · cited 3× · doi

  Comprehensive Summary Although asymmetric catalytic synthesis via dynamic kinetic resolution has proven to serve as a powerful tool for the efficient preparation of planar chiral pillar[5]arenes, the enantioselective synthesis of highly‐functionalized pillar[5]arenes with more than two functional groups remains rarely explored.

  generalabstractevidence 5/5
  Keywords: synthesis pillar arenes comprehensive summary asymmetric catalytic dynamic kinetic resolution proven serve powerful tool efficient
• Synthesis of Chiral Diamides via IDPA Catalyzed Dynamic Kinetic Resolution of Oxazolidinones (2026) · Chemical Research in Chinese Universities · doi

  The gap in existing methods is the requirement for chiral starting materials or sterically hindered amines. The authors identify a need for a general and highly enantioselective catalytic approach for the synthesis of chiral diamides. The paper highlights the limitation of existing methods in terms of yield and enantioselectivity.

  generalstated research gapevidence 5/5
  Keywords: gap existing methods requirement chiral starting materials sterically
• DFT Calculation-Assisted Virtual Screening to Refine Chiral Phosphoric Acid-Catalyzed Allylboration Enabling Organocatalytic Synthesis of Tetrafibricin C21–C40 Fragment (2026) · JACS Au · doi

  This strategy led to the discovery of previously underexplored 9-anthryl-substituted chiral phosphoric acids as optimal catalysts for the enantioselective allylboration of functionalized alkyl aldehydes, thereby eliminating the need to prepare multiple complex catalysts by trial and error.

  generalabstractevidence 4/5
  Keywords: catalysts strategy discovery previously underexplored anthryl substituted chiral phosphoric acids optimal enantioselective allylboration functionalized alkyl

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