Further analysis of the causal relationships
Research gap analysis derived from 3 psychology papers in our local library.
The gap
further analysis of the causal relationships between multimorbidity patterns and depression is needed, - investigation of the potential multifactorial pathophysiological or psychosocial mechanisms linking multimorbidity patterns to depressi
Evidence profile
Sourced from the future-work section and limitations and abstract of the source papers, classified as general, drawn from work published between 2017 and 2026, spanning 3 journals. Those papers have been cited 158 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- Multimorbidity Patterns and Depression: Bridging Epidemiological Associations with Predictive Analytics for Risk Stratification (2025) · Healthcare · cited 7× · doi
further analysis of the causal relationships between multimorbidity patterns and depression is needed, - investigation of the potential multifactorial pathophysiological or psychosocial mechanisms linking multimorbidity patterns to depression, - exploration of the generalizability of the findings to other populations
generalfuture-work sectionKeywords: further analysis causal relationships between multimorbidity patterns depression - Associations between self-reported depression and functioning across ICF domains: a Danish population-based study (2026) · Frontiers in Rehabilitation Sciences · doi
in functioning tend to cluster across domains. However, as adjusted models included variables that may lie on the pathway between depression and functioning, some degree of overadjustment cannot be excluded, and these estimates should be interpreted with caution. While additional adjustment for personal and environmental factors did not substantially alter the overall pattern of association, residual confounding and potential bidirectional excluded.
generallimitationsevidence 5/5Keywords: functioning excluded tend cluster across domains adjusted models included variables pathway depression degree overadjustment cannot - A systematic review of the unique prospective association of negative affect symptoms and adolescent substance use controlling for externalizing symptoms. (2017) · Psychology of Addictive Behaviors · cited 151× · doi
Mixed findings regarding the depression-substance use association, however, also call for greater attention to potential moderating factors that may help define who, when, and in what context depression serves as an important risk factor for later substance use above and beyond risk associated with externalizing symptoms.
generalabstractevidence 5/5Keywords: depression substance risk mixed regarding association call greater attention potential moderating factors help define context
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