The mechanisms underlying the association between plasma VWF levels and cognitive decline
Research gap analysis derived from 4 psychology papers in our local library.
The gap
Further studies are needed to investigate the mechanisms underlying the association between plasma VWF levels and cognitive decline. Longitudinal studies with larger sample sizes are needed to confirm the findings. Studies examining the rel
Evidence profile
Sourced from the future-work section and stated research gap and abstract of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 4 journals. Those papers have been cited 16 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 4 representative gaps
- Plasma phosphorylated tau 217 and neurofilament light chain on the association between depressive symptoms and cognitive decline: The Shanghai Aging Study (2026) · Psychological Medicine · cited 2× · doi
Investigate the underlying mechanisms of the relationship between depressive symptoms and cognitive decline in detail. Examine the relationship between depressive symptoms and cognitive decline in different populations. Explore the potential of plasma biomarkers for screening and diagnosing dementia. Investigate the effects of interventions targeting depressive symptoms on cognitive decline
generalfuture-work sectionevidence 5/5Keywords: investigate underlying mechanisms relationship between depressive symptoms cognitive - Relationship Between Depression and Neurodegeneration: Risk Factor, Prodrome, Consequence, or Something Else? A Scoping Review (2025) · Biomedicines · cited 13× · doi
The evidence supporting a spurious or dissociated relationship between depression and neurodegeneration is notably less robust than for the other hypotheses examined in this review. Few studies have systematically examined the possibility that the observed comorbidity might be coincidental or mediated entirely by third variables.
generalstated research gapevidence 5/5Keywords: evidence supporting spurious dissociated relationship between depression neurodegeneration - Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia (2025) · Frontiers in Aging Neuroscience · cited 1× · doi
Further studies are needed to investigate the mechanisms underlying the association between plasma VWF levels and cognitive decline. Longitudinal studies with larger sample sizes are needed to confirm the findings. Studies examining the relationship between VWF and other biomarkers of Alzheimer’s disease are needed.
generalfuture-work sectionevidence 5/5Keywords: further studies needed investigate mechanisms underlying association between - The impact of late-life depression on cognitive performance in older adults with mild cognitive impairment: a systematic review protocol (2026) · Systematic Reviews · doi
Although depression is a well-established risk factor for the progression from mild cognitive impairment (MCI) to dementia, there is still no consensus in the literature regarding the specific impact of this comorbidity on the neuropsychological profile: while some studies suggest a predominantly dysexecutive profile, others emphasise deficits in attention or in memory.
generalabstractevidence 5/5Keywords: profile depression well established risk factor progression mild cognitive impairment dementia there still consensus literature
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