The abnormal patterns of functional network connectivity in late-onset depression remain unclear
Research gap analysis derived from 3 psychology papers in our local library.
The gap
The abnormal patterns of functional network connectivity in late-onset depression remain unclear. The relationship between depressive symptoms and cognitive decline in late-onset depression is not well understood. There is a need to identif
Evidence profile
Sourced from the abstract and stated research gap of the source papers, classified as general, drawn from work published between 2025 and 2026, all from Psychological Medicine. Those papers have been cited 11 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- Disrupted functional connectivity of the emotion regulation network in major depressive disorder and its association with symptom improvement: A multisite resting-state functional MRI study (2025) · Psychological Medicine · cited 8× · doi
Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.
generalabstractevidence 5/5Keywords: whether abnormal previous neuroimaging investigated neurobiological correlates major depressive disorder patients exhibit functional connectivity patterns - Shared and distinct alterations in brain connectivity and cognitive function in subthreshold and major depression (2026) · Psychological Medicine · cited 2× · doi
There is a lack of understanding of the neurobiological mechanisms of subthreshold depression. The relationship between functional connectivity and cognitive function in subthreshold depression and major depressive disorder is not well understood. The specific brain regions and networks that are altered in subthreshold depression and major depressive disorder are not well identified.
generalstated research gapevidence 4/5Keywords: there lack understanding neurobiological mechanisms subthreshold depression relationship - Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression (2025) · Psychological Medicine · cited 1× · doi
The abnormal patterns of functional network connectivity in late-onset depression remain unclear. The relationship between depressive symptoms and cognitive decline in late-onset depression is not well understood. There is a need to identify biomarkers for depression and cognitive decline in late-onset depression.
generalstated research gapevidence 4/5Keywords: abnormal patterns functional network connectivity late-onset depression remain
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