High to related [30]
Research gap analysis derived from 3 psychology papers in our local library.
The gap
High to related; however, study, we used CORT levels of glucocorticoids are closely associated with depression the underlying mechanism remains unclear. However, to our knowledge, the effect of CORT on AHN the in mice, especially on developmental lineage of NSCs, has not been reported.
Evidence profile
Sourced from the stated research gap and discussion and stated challenges of the source papers, classified as general, drawn from work published between 2023 and 2026, spanning 2 journals. Those papers have been cited 405 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- Comparative Evaluation of Corticosterone Administration, Chronic Restraint Stress, and Their Combination for Depression-like Behavioral and Molecular Alterations in Mice: A Multi-Domain Assessment (2026) · International Journal of Molecular Sciences · doi
The lack of a comprehensive multi-domain comparison of corticosterone, chronic restraint stress, and their combination. The need for improved preclinical models of depression, particularly those that integrate multiple pathological domains. The gap in understanding the effects of combining corticosterone with chronic restraint stress on depression-like behavioral and molecular alterations.
generalstated research gapevidence 5/5Keywords: lack comprehensive multi-domain comparison corticosterone chronic restraint stress - Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression (2023) · Theranostics · cited 208× · doi
High to related [30]; however, study, we used CORT levels of glucocorticoids are closely associated with depression the underlying mechanism remains unclear. However, to our knowledge, the effect of CORT on AHN the in mice, especially on developmental lineage of NSCs, has not been reported.
generaldiscussionevidence 5/5Keywords: cort high related used levels glucocorticoids closely associated depression underlying mechanism remains unclear knowledge effect - Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review (2025) · International Journal of Molecular Sciences · cited 197× · doi
Chronic stress disrupts the negative feedback system of glucocorticoids, leading to abnormal alterations in the higher centres of the HPA axis. The hyperactivity of the HPA axis may be a primary factor leading to depression, particularly in the context of chronic stress conditions. The paper identifies the need to develop effective interventions for depressive disorders, which is a complex challenge.
generalstated challengesevidence 5/5Keywords: chronic stress disrupts negative feedback system glucocorticoids leading
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