The development of effective wound healing therapies is a significant challenge in modern healthcare systems

The gap

Evidence profile

Sourced from the stated challenges and future work of the source papers, classified as general, drawn from work published between 2024 and 2026, spanning 3 journals. Those papers have been cited 22 times in total.

Supporting evidence — 3 representative gaps

• Wound Healing Potential of Herbal Hydrogel Formulations of Cedrus brevifolia Extracts in Mice (2024) · Gels · cited 5× · doi

  The development of effective wound healing therapies is a significant challenge in modern healthcare systems. The transition from in vitro findings to in vivo outcomes is a critical challenge in confirming the potential of C. brevifolia extracts in wound healing. The identification of the precise mechanisms of action and the individual contributions of each compound in the C. brevifolia extracts is a challenge that warrants further exploration.

  generalstated challenges
  Keywords: development effective wound healing therapies significant challenge modern
• IN SILICO ASSESSMENT OF BURN HEALING PROPERTIES OF BIOACTIVE COMPOUNDS FROM FICUS RELIGIOSA LEAVES USING MOLECULAR DOCKING STUDIES (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi

  Future studies should focus on:    Isolation and characterization of active compounds In-vitro wound healing assays In-vivo burn wound models  Clinical evaluation of herbal formulations REFERENCE 1. Kumar V, Chauhan NS, Padh H, Rajani M. Search for antibacterial and antifungal agents from selected Indian medicinal plants. Journal of Ethnopharmacology, 2006; 107(2): 182-188. 2. Sharma SK, Singh AP. In vitro antioxidant and free radical scavenging activity of Ficus religiosa. Journal of Pharmacy Research, 2010; 3(7): 1483-1485. www.wjpr.net │ Vol 15, Issue 8, 2026. │ ISO 9001: 2015 Certified Journal │ 402 Aruna et al. World Journal of Pharmaceutical Research 3. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Dehradun: International Book Distributors, 2005. 4. Trease GE, Evans WC. Trease and Evans Pharmacognosy. 16th ed. London: Saunders Elsevier, 2009. 5. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 49th ed. Pune: Nirali Prakashan, 2014. 6. Sarker SD, Nahar L. Natural Products Isolation. 3rd ed. Totowa: Humana Press, 2012. 7. Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies, 2004; 1(4): 337-341. 8. Lionta E, Spyrou G, Vassilatis DK, Cournia Z. Structure-based virtual screening for drug discovery. Current Topics in Medicinal Chemistry, 2014; 14(16): 1923-1938. 9. Meng XY, Zhang HX, Mezei M, Cui M. Molecular docking: A powerful approach for structure-based drug discovery. Current Computer-Aided Drug Design, 2011; 7(2): 146-157. 10. Newman DJ, Cragg GM. Natural products as sources of new drugs. Journal of Natural Products, 2016; 79(3): 629-661. 11. Balouiri M, Sadiki M, Ibnsouda SK. Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis, 2016; 6(2): 71-79. 12. Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD. Molecular properties that influence oral bioavailability. Journal of Medicinal Chemistry, 2002; 45(12): 2615-2623. 13. Irwin JJ, Shoichet BK. ZINC – a free database of commercially available compounds for virtual screening. Journal of Chemical Information and Modeling, 2005; 45(1): 177-182. 14. Dallakyan S, Olson AJ. Small-molecule library screening by docking with PyRx. Methods in Molecular Biology, 2015; 1263: 243-250. 15. Morris GM et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 2009; 30(16): 2785-2791. www.wjpr.net │ Vol 15, Issue 8, 2026. │ ISO 9001: 2015 Certified Journal │ 403

  generalfuture workevidence 5/5
  Keywords: journal drug medicinal compounds vitro natural products discovery screening chemistry molecular docking isolation wound indian
• Molecular Mechanisms of Wound Healing: The Role of Medicinal Plants (2025) · Life · cited 17× · doi

  Despite growing evidence for the therapeutic effects of medicinal plants in wound healing, translation into clinical practice remains limited. Future research should priori- tize the development of advanced drug delivery systems capable of improving stability, bioavailability, and targeted action of plant compounds. Localized delivery strategies allow sustained release of bioactive compounds at the wound site, minimize systemic exposure, and can be engineered to respond to the dynamic microenvironment of healing tissue. Inte- grating plant-derived bioactive compounds with modern biomaterials offers a promising approach for next-generation wound therapeutics. Further preclinical and clinical studies are needed to optimize local delivery systems, ensuring safety, reproducibility, and efficacy. Author Contributions: Conceptualization, M.E., E.A. and A.B.; methodology, M.E.; software, M.P.; validation, A.B., E.A. and V.K.; formal analysis, M.E., E.A. and A.B.; investigation, I.D. and M.C.; resources, M.E.; data curation, M.E.; writing—original draft preparation, M.E.; writing—review and editing, M.E., I.D., M.C., E.A., V.K. and A.B.; visualization, M.E. and M.P.; supervision, E.A., V.K. and A.B.; project administration, I.D.; funding acquisition, A.B. and E.A. All authors have read and agreed to the published version of the manuscript. Funding: This study is financed by the European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria, project No. BG-RRP-2.004-0007-C03. Institutional Review Board Statement: Not applicable. Informed Consent Statement: Not applicable. Data Availability Statement: Not applicable. Conflicts of Interest: The authors declare no conflicts of interest. Life 2025, 15, 1748

  generalfuture workevidence 5/5
  Keywords: wound delivery compounds statement applicable healing clinical systems plant bioactive writing review project funding authors

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