The need for eco-friendly methods for producing

The gap

Evidence profile

Stated in the cells research gap and cells future research and abstract sections of the source papers, classified as general, spanning 5 journals.

Supporting evidence — 8 representative gaps

• Analysis and optimization of Biodentine with cefixime-loaded zinc oxide nanoparticles in terms of mechanical properties and hydrolytic degradation (2026) · Dental Materials Journal · doi

  The need for novel biomaterials with improved mechanical properties and antimicrobial action. - The lack of effective treatments for dentine damage. - The potential for ZnO nanoparticles to enhance the material's bioavailability and stability.

  generalstated in cells research gapevidence 5/5
  Keywords: need novel biomaterials improved mechanical properties antimicrobial action
• Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential (2026) · Journal of Materials Science: Materials in Medicine · doi

  There is a need for alternative approaches to improve therapeutics delivery and reduce non-specific effects. - The cytotoxic effects of ZnO₂ nanoparticles on breast cancer cells and fibroblasts need to be evaluated.

  generalstated in cells research gapevidence 5/5
  Keywords: there need alternative approaches improve therapeutics delivery reduce
• Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential (2026) · Journal of Materials Science: Materials in Medicine · doi

  Further studies are required to validate these observations in more complex biological systems. - The underlying mechanisms of the cytotoxic effects of ZnO₂ nanoparticles need to be clarified. - In vivo studies are needed to explore the potential of ZnO₂ nanoparticles in clinical applications.

  generalstated in cells future researchevidence 5/5
  Keywords: further studies required validate observations complex biological systems
• Biogenic synthesis of zinc oxide nanoparticles by Coleus amboinicus extract: its spectral analysis and biological activities (2026) · Zastita materijala · doi

  The need for a green and environmentally friendly method for the synthesis of zinc oxide nanoparticles. - The lack of studies on the spectral analysis and biological activities of ZnO NPs synthesized using plant extracts.

  generalstated in cells research gapevidence 5/5
  Keywords: need green environmentally friendly method synthesis zinc oxide
• Biogenic synthesis of zinc oxide nanoparticles by Coleus amboinicus extract: its spectral analysis and biological activities (2026) · Zastita materijala · doi

  Investigation of the potential applications of ZnO NPs in biomedical and cosmetic fields. - Evaluation of the toxicity and biocompatibility of ZnO NPs synthesized using CALE. - Development of new methods for the synthesis of ZnO NPs using plant extracts.

  generalstated in cells future researchevidence 5/5
  Keywords: investigation potential applications zno nps biomedical cosmetic fields
• Green synthesis and optimized annealing temperature effects on zinc oxide nanoparticles using mango peel extract (2026) · Journal of Metals Materials and Minerals · doi

  The need for environmentally friendly methods for synthesizing ZnO nanoparticles. - The lack of optimization of the annealing temperature to produce pure ZnO nanoparticles.

  generalstated in cells research gapevidence 5/5
  Keywords: need environmentally friendly methods synthesizing zno nanoparticles lack
• Green synthesis and optimized annealing temperature effects on zinc oxide nanoparticles using mango peel extract (2026) · Journal of Metals Materials and Minerals · doi

  Further optimization of the synthesis conditions to improve the yield and purity of ZnO nanoparticles. - Investigation of the antimicrobial activity of the synthesized ZnO nanoparticles against other microorganisms.

  generalstated in cells future researchevidence 5/5
  Keywords: further optimization synthesis conditions improve yield purity zno
• In situ formation of ZnO nanoparticles in PEG 400 under microwave solvothermal conditions using a design of experiments approach (2026) · Journal of Materials Science · doi

  Abstract Zinc oxide (ZnO) nanoparticles are widely used in cosmetic and pharmaceutical formulations; however, their dispersion in viscous organic media is often limited by aggregation and poor compatibility.

  generalstated in abstractevidence 4/5
  Keywords: abstract zinc oxide nanoparticles widely used cosmetic pharmaceutical formulations dispersion viscous organic media often limited

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