The need for new antimicrobial compounds from natural sources due to the escalating global burden of antimicrobial resistance

The gap

Evidence profile

Sourced from the stated research gap and stated challenges of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 3 journals. Those papers have been cited 34 times in total.

Supporting evidence — 6 representative gaps

• A Novel Bis-Spiroketal Scaffold and Other Secondary Metabolites from the Marine-Derived Fungus Talaromyces stipitatus HF05001: Structural Diversity and Bioactivities (2026) · Marine Drugs · cited 1× · doi

  The research gap is not explicitly stated in the paper, but it can be inferred as the need for further investigation into the secondary metabolites of marine-derived fungi. The gap may also be related to the limited understanding of the biological activities of these metabolites.

  generalstated research gap
  Keywords: research gap explicitly stated paper inferred need further
• Corallomycetellains A–J, Cytotoxic Epipolythiodioxopiperazine Alkaloids Isolated from the Fungi Corallomycetella repens HDN23-0007 (2026) · Marine Drugs · cited 2× · doi

  The paper identifies a gap in the chemical diversity of marine fungal metabolites. The study aims to provide promising leads for the development of novel anticancer agents. The research gap is also related to the need for new epipolythiodioxopiperazine alkaloids with strong anticancer activity.

  generalstated research gap
  Keywords: paper identifies gap chemical diversity marine fungal metabolites
• New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440 (2026) · Marine Drugs · doi

  The paper does not explicitly state the research gap, but it can be inferred as the need to explore the pharmacological activities of secondary metabolites produced by mangrove-derived fungi. The study highlights the importance of investigating the structural elucidation and stereochemical assignment of new compounds. The paper identifies the need to discover new compounds with potential therapeutic applications.

  generalstated research gap
  Keywords: paper does explicitly state research gap inferred need
• Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy (2026) · Marine Drugs · doi

  The challenge of inducing the production of new compounds from marine-derived fungi. The need to evaluate the antimicrobial and cytotoxic activities of the isolated compounds. The challenge of identifying promising anti-candidal agents with cardioprotective effects.

  generalstated challenges
  Keywords: challenge inducing production new compounds marine-derived fungi need
• Revisiting Traditional Medicinal Plants: Integrating Multiomics, In Vitro Culture, and Elicitation to Unlock Bioactive Potential (2025) · Plants · cited 31× · doi

  The therapeutic potential of many traditional medicinal plants remains underexplored. A significant proportion of pharmacologically active constituents yet to be identified or mechanistically characterized. The need for controlled, sustainable production platforms for secondary metabolites.

  generalstated research gapevidence 5/5
  Keywords: therapeutic potential many traditional medicinal plants remains underexplored
• “Edible plant-associated fungal endophytes as sources of bioactive specialized metabolites: antimicrobial and docking insights” (2026) · Archives of Microbiology · doi

  The need for new antimicrobial compounds from natural sources due to the escalating global burden of antimicrobial resistance. The limited exploration of edible plant-associated fungal endophytes as sources of bioactive specialized metabolites.

  generalstated research gapevidence 5/5
  Keywords: need new antimicrobial compounds natural sources due escalating

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