Knowledge on atypical dengue manifestations in children

The gap

Evidence profile

Stated in the limitations and cells research gap sections of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 3 representative gaps

• Spectrum of Clinical Profile of Dengue Syndrome Admitted in Dengue Referral Center (2026) · Open MIND · doi

  The study was conducted in a single referral center with a relatively small sample size. So the results may not represent the whole community. is consistent with recent observations CONCLUSION Dengue infection presents with a wide range of clinical manifestations among hospitalized patients. In this study, fever, headache, myalgia, and arthralgia were the most common presenting symptoms. Notably, gastrointestinal manifestations were prominent, with diarrhea emerging as one of the most frequent clinical features, while cutaneous manifestations such as rash were observed less frequently.

  generalstated in limitationsevidence 5/5
  Keywords: manifestations clinical conducted single referral center relatively small sample size represent whole community consistent recent
• Clinical characteristics and outcomes of dengue-associated transverse myelitis: A systematic review of case reports (2026) · Neurological Sciences · doi

  This review has important limitations. The evidence base consists entirely of case reports, which are vulnerable to publication bias, selective reporting, and heterogeneity in diagnostic evaluation and outcome assessment. Variability in diagnostic criteria and incomplete exclusion of alter- native causes introduce potential misclassification bias. Dengue serotype, autoimmune testing, standardized dis- ability scores and duration of follow-up were inconsistently reported, limiting mechanistic inference and prognosis stratification. The most frequently unmet quality criterion was explicit reporting of adverse events, which may have led to underestimation of treatment-related complications. Because case reports do not allow estimation of incidence or comparative treatment efficacy, causal inferences remain limited.

  generalstated in limitationsevidence 5/5
  Keywords: case reports bias reporting diagnostic treatment review important limitations evidence base consists entirely vulnerable publication
• Atypical manifestations of dengue in pediatric patients hospitalized during the 2023–2024 epidemic in Argentina: a multicenter registry (2026) · European Journal of Pediatrics · doi

  There is a gap in knowledge on atypical dengue manifestations in children. - Prior studies have focused on typical dengue manifestations, and there is a need for research on atypical complications. - The study aims to address this gap by characterizing encephalitis, myositis, and myocarditis in hospitalized children during the 2023-2024 dengue epidemic in Argentina.

  generalstated in cells research gapevidence 5/5
  Keywords: there gap knowledge atypical dengue manifestations children prior

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