Examine the associations between depression

The gap

Evidence profile

Sourced from the future-work section and abstract and inline gaps and stated research gap of the source papers, classified as general, drawn from work published between 2009 and 2026, spanning 5 journals. Those papers have been cited 279 times in total.

Supporting evidence — 5 representative gaps

• Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference (2024) · Nature Genetics · cited 174× · doi

  Future studies should aim to replicate the findings in larger and more diverse populations. Future studies should investigate the relationship between major depression and other traits in diverse populations. Future studies should consider ancestry-specific effects in genetic studies of major depression.

  generalfuture-work section
  Keywords: future studies aim replicate findings larger diverse populations
• The Prevention of Depression in Children and Adolescents: A Review (2009) · The Canadian Journal of Psychiatry · cited 105× · doi

  Future research is needed to establish an empirical base for the prevention of depression in high-risk youth and should: focus on targeted and indicated prevention approaches, attend to moderators of intervention effects, include approaches that aim to enhance the family environment, attend to nonspecific risk factors for disorder, and focus on the dissemination phase of prevention research.

  generalabstractevidence 5/5
  Keywords: prevention risk focus approaches attend future needed establish empirical base depression high youth targeted moderators
• Exploring Depression among Adolescents with Antisocial Behavioral Tendencies (2026) · Journal of Health and Behavioral Science · doi

  In addition, future research should examine contextual factors such as parenting practices, family relationships, cultural influences, and differences across age and gender to provide a more comprehensive understanding of adolescents’ psychological experiences. Future research is recommended to employ longitudinal and/or mixed- methods designs to better understand how depression and antisocial behavioral tendencies develop and interact over time.

  generalinline gapsevidence 5/5
  Keywords: future addition examine contextual factors parenting practices family relationships cultural influences differences across gender provide
• The impact of family cohesion and adaptability on depressive symptoms in adolescents with depression: a cross-sectional study in China (2026) · Scientific Reports · doi

  Although our findings demonstrate significant associations, the direction of these effects remains unclear. Second, given that our sample consists of adolescents diagnosed with depression, the external validity of our findings is limited to clinical populations. Future longitudinal or prospective studies are warranted to further clarify the temporal precedence and causal pathways between these variables. Although efforts were made to enhance representativeness through multicenter stratification, future studies employing probability-based or population-based sampling are warranted.

  generalinline gapsevidence 5/5
  Keywords: future warranted based demonstrate significant associations direction effects remains unclear second given sample consists adolescents
• Associations between self-reported depression and functioning across ICF domains: a Danish population-based study (2026) · Frontiers in Rehabilitation Sciences · doi

  There is a need to examine the associations between depression and functioning across multiple domains, rather than solely focusing on symptom severity. The study addresses the gap in research by using a stratified random sample of Danish adults and accounting for environmental and personal factors.

  generalstated research gapevidence 5/5
  Keywords: there need examine associations between depression functioning across

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