A specific beneficial role of Citicoline in enhancing contrast sensitivity

The gap

Evidence profile

Sourced from the conclusions and recommendations and discussion of the source papers, classified as general, spanning 4 journals.

Supporting evidence — 5 representative gaps

• The effect of citicoline administration on visual function improvement in stroke patients at Prof. Dr. Chairuddin Panusunan Lubis Hospital, University of Sumatera Utara, and affiliated network hospitals (2026) · Frontiers in Medicine · doi

  These findings suggest a specific beneficial role of Citicoline in enhancing contrast sensitivity, while its influence on other visual parameters is inconclusive. Given the limited sample size and short intervention period, fur- ther research with larger cohorts, extended treatment duration, and potential combination with other neuroprotective agents is warranted to comprehensively evaluate the neurovisual benefits of Citicoline in post-stroke rehabilitation.

  generalconclusions
  Keywords: citicoline suggest specific beneficial role enhancing contrast sensitivity influence visual parameters inconclusive given limited sample
• Herbal medicine for mild cognitive impairment: Neuroimaging perspectives (2026) · World Journal of Clinical Cases · doi

  19. Tian J, Xie H, Qin B, Fan D, Shi J, Wang L. Chinese diagnostic guidelines of vascular mild cognitive impairment. Chin J Intern Med. (2016) 3:249–56. 20. WHO. Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization (2019). 21. Brien JTO, Holmes C, Jones M, Jones R, Livingston G, McKeith I, et al. Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol. (2017) 31:147–68. doi: 10.1177/0269881116680924 22. Herukka SK, Simonsen AH, Andreasen N, Baldeiras I, Bjerke M, Blennow K, et al. Recommendations for cerebrospinal fluid Alzheimer’s evaluation of mild cognitive disease biomarkers impairment. Alzheimers Dement. (2017) 13:285–95. doi: 10.1016/j.jalz.2016. 09.009 in the diagnostic al. European Association of Nuclear Medicine 23. Nobili F, Arbizu J, Bouwman F, Drzezga A, Agosta F, Nestor P, and European brain in dementia: Delphi 10.1111/ene. doi: et

  generalrecommendations
  Keywords: cognitive dementia diagnostic guidelines mild impairment jones association european tian wang chinese vascular chin intern
• Use of Citicoline in Aging Process and Cognitive Impairment: A Systematic Review of Current Clinical Evidence (2026) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi

  Clinical studies conducted in healthy older adults with age-related memory impairment have reported mixed findings regarding the effects of citicoline use on cognitive performance. Clinical studies evaluating the effects of citicoline across the spectrum of mild cognitive impairment (MCI) and dementia report findings suggesting improvement in certain cognitive domains; however, they indicate that results are inconsistent across studies.

  generaldiscussion
  Keywords: cognitive clinical impairment effects citicoline across conducted healthy older adults related memory reported mixed regarding
• Use of Citicoline in Aging Process and Cognitive Impairment: A Systematic Review of Current Clinical Evidence (2026) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi

  These findings suggest that citicoline may continue to be investigated as an adjunctive approach, particularly in cognitive disorders with a vascular component or in patients in the early stages of the disease; however, there is insufficient evidence to support its routine use in clinical practice. However, a significant portion of these mechanistic inferences is based on preclinical data, and their direct translation into clinical outcomes remains uncertain. The findings from this systematic review indicate that citicoline has potentially beneficial effects on cognitive function in age-related cognitive decline, mild cognitive impairment, and the early stages of dementia; however, the current evidence is limited, heterogeneous, and predominantly of low to moderate methodological quality. Although improvements in attention, memory, and executive function have been reported in some randomized controlled and observational studies, particularly with oral citicoline doses of 500–1000 mg/day, the consistency and generalizability of these findings are limited.

  generalconclusions
  Keywords: cognitive citicoline particularly early stages evidence clinical function limited suggest continue investigated adjunctive approach disorders
• Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research (2026) · Frontiers in Aging Neuroscience · doi

  research Maria Dobrushina1,2†, Friedrich Krohn1,2†, Sayyeda Chandni1,2, Linda Dietrich3, Wenzel Glanz2,4, Michaela Butryn2,4, Dorothea Hämmerer1,2,5,6,7 and Lucía Penalba-Sánchez1,2* 1Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 3University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland, 4Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany, 5Institute of Cognitive Neuroscience, University College London (UCL), London, United Kingdom, 6Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany, 7Department of Psychology, University of Innsbruck, Innsbruck, Austria interventions neuroimaging pharmacological in with

  generalrecommendations
  Keywords: university magdeburg germany institute cognitive neurology otto guericke center bern department london innsbruck maria dobrushina

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