How many papers support this gap analysis?

3 papers from our local library contribute to this synthesis, with an average publication year of 2026.

Can I get a manuscript addressing this gap reviewed here?

Yes — AI Review runs 8 specialist agents over the full PDF and returns a structured editorial report in one pass, for 30 credits. Start at /review. A journal publication route is planned; it is not open for submissions yet.

chemistry3 papersavg year 2026weak evidence

Traditional HPLC techniques have been associated with the use of harmful organic solvents and production of large amounts of chemical waste

Research gap analysis derived from 3 chemistry papers in our local library.

The gap

Traditional HPLC techniques have been associated with the use of harmful organic solvents and production of large amounts of chemical waste. The need for an environmentally sustainable method of pharmaceutical analysis. The development of Green HPLC method for dissolution profiling of pharmaceutical drugs.

Evidence profile

Sourced from the future-work section and limitations section and stated research gap of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 2 journals. Those papers have been cited 37 times in total.

Research trend

Established — well-defined area with open sub-problems.

Supporting evidence — 4 representative gaps

GREEN HPTLC AND HPLC: CHALLENGES IN STANDARDIZATION AND PRACTICAL IMPLEMENTATION IN PHARMACEUTICAL ANALYSIS (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
The development of standardized evaluation frameworks for green analytical methods. The application of Life Cycle Assessment (LCA) for evaluating the environmental impact of chromatographic methods. The exploration of new eco-friendly solvents and optimized chromatographic conditions for green HPTLC and HPLC methods.
generalfuture-work sectionevidence 5/5
Keywords: development standardized evaluation frameworks green analytical methods application
GREEN HPTLC AND HPLC: CHALLENGES IN STANDARDIZATION AND PRACTICAL IMPLEMENTATION IN PHARMACEUTICAL ANALYSIS (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
Scalability limitations and instrument compatibility issues hinder widespread implementation of green HPTLC and HPLC methods. Variations in solvent properties and increased system backpressure can limit flow rate flexibility and reduce column lifespan. The lack of standardized evaluation frameworks and regulatory guidelines restricts the acceptance and transferability of green analytical methods.
generallimitations sectionevidence 5/5
Keywords: scalability limitations instrument compatibility issues hinder widespread implementation
A REVIEW ON GREEN HPLC METHOD DEVELOPMENT FOR DISSOLUTION PROFILING OF PHARMACEUTICAL DRUGS (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
Traditional HPLC techniques have been associated with the use of harmful organic solvents and production of large amounts of chemical waste. The need for an environmentally sustainable method of pharmaceutical analysis. The development of Green HPLC method for dissolution profiling of pharmaceutical drugs.
generalstated research gapevidence 5/5
Keywords: traditional hplc techniques have been associated use harmful
Green Approaches in High-Performance Liquid Chromatography for Sustainable Food Analysis: Advances, Challenges, and Regulatory Perspectives (2025) · Molecules · cited 37× · doi
The paper identifies the need for reliable metrics to assess the environmental impact and effectiveness of green analytical practices. It highlights the limitations in analytical performance and limited instrument availability. The paper notes the requirement for specialized training and system maintenance for miniaturized LC.
generalstated research gapevidence 5/5
Keywords: paper identifies need reliable metrics assess environmental impact

Questions about this gap

Traditional HPLC techniques have been associated with the use of harmful organic solvents and production of large amounts of chemical waste. The need for an environmentally sustainable method of… This is supported by 4 representative gap statements extracted from 3 papers, rated weak evidence.

Explore this gap further

Run this gap as a query across open scholarly engines for the latest related literature.

Find research gaps on this topic →Google Scholar ↗Semantic Scholar ↗OpenAlex ↗Europe PMC ↗CORE ↗

Working on this gap? Review it with us.

AI Review reads your manuscript in one pass with 8 specialist agents, calibrated on 69K+ real peer reviews.

Run an AI review Run a pre-submission check

Tools for your next paper

Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.AI Review8 specialist agents return an editor-ready review of your full PDF.

How Pre-Check works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.