Science AI Journal
Medicine · Research topic

Open research questions in Adipose Tissue and Metabolism

135 unresolved questions extracted from the limitations and future-work sections of 427 Adipose Tissue and Metabolism papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Genome assembly and gap closure - Identification of repetitive sequences and protein-coding genes - Comparative genomic analysis and phylogenetic tree construction - Integration of transcriptome and metabolome data

    A telomere-to-telomere genome reveals arachidonic acid as a key regulator of hepatic lipid metabolism during hibernation · 2026 · DOI

  • Investigation of the substrate concentrations required to permit non-enzymatic acetylation across a broad spectrum of amino acids, - Study of the occurrence of non-enzymatic acetylation reactions under physiological conditions and in which tissues they may be relevant

    N-acetylated amino acids: An overlooked layer of metabolic regulation · 2026 · DOI

  • Investigations of thermogenic adipose depots in pigs are relatively scarce and less precise, - Experimental and technical limitations exist, - Only a limited number of studies have employed PET-CT to investigate thermogenic adipose depots in pigs

    Effects of Cold Stress on the Morphology and Thermogenic Capacity of Adipose Tissue in Various Anatomical Depots of Min pigs · 2026 · DOI

  • Further studies are needed to investigate the thermogenic capacity of adipose tissues in response to cold stress, - The use of PET-CT to investigate thermogenic adipose depots in pigs should be explored, - The molecular mechanisms underlying the beiging response in inguinal depots should be investigated

    Effects of Cold Stress on the Morphology and Thermogenic Capacity of Adipose Tissue in Various Anatomical Depots of Min pigs · 2026 · DOI

  • The paper identifies the challenge of characterizing the structure of the evidence and the biological relations examined across the field, given the diversity of mediator classes, exercise paradigms, disease contexts, and experimental models. The review also notes the challenge of synthesizing the evidence, given the complexity of the relationships between exercise, mediators, and cardiometabolic outcomes. The paper highlights the need for further research to investigate the molecular signals accompanying exercise and their role in preventing and managing diabetes and related cardiometabolic disorders.

    Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map · 2026 · DOI

  • Investigation of less frequently investigated signals, - Further research on the molecular signals that accompany exercise and participate in communication among tissues

    Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map · 2026 · DOI

  • future mechanistic research on TDRKH and METAP1D, - therapeutic development based on the findings

    Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective · 2025 · DOI

  • The causal contributions of specific mitochondrial genes across regulatory layers in the pathogenesis of MDD remain unclear. Prior research has examined mitochondria and MDD at selected molecular levels, but a systematic framework to identify high-confidence candidate genes is lacking.

    Decoding nuclear-encoded mitochondrial genes in major depressive disorder: A multi-omics perspective · 2025 · DOI

  • Insufficient delivery efficiency to insulin-sensitive tissues, - Complex regulatory feedback loops involving ROS and miRNAs, - The clinical translation of therapies is constrained by multiple factors, - The magnitude and tissue specificity of miRNAs in human T2DM remain to be defined

    Mitochondrial bioenergetics dysfunction in T2DM: linking oxidative stress to insulin resistance · 2025 · DOI

  • Elucidating the precise mechanism by which succinate affects insulin signaling, - Investigating the role of miRNAs in linking mitochondrial function and redox balance to insulin action, - Developing strategies to optimize the delivery of therapeutic agents to insulin-sensitive tissues, - Understanding the complex regulatory feedback loops involving ROS and miRNAs

    Mitochondrial bioenergetics dysfunction in T2DM: linking oxidative stress to insulin resistance · 2025 · DOI

  • Further studies are needed to understand the molecular mechanisms underlying the effects of semaglutide and tirzepatide, - Investigations into the potential therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists are warranted, - Research into the effects of semaglutide and tirzepatide on other tissues and organs is necessary

    Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet · 2025 · DOI

  • The exact molecular mechanisms of GLP-1 and dual GIP/GLP-1 receptor agonists on brown adipose tissue remain incompletely understood. The disparity in DEG counts between semaglutide and tirzepatide treatment groups is not well understood.

    Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet · 2025 · DOI

  • The paper identifies the challenge of understanding the complex relationships between diet, cellular oxidative stress, and glucose homeostasis. It highlights the need to consider the role of RBD seed oils in the development of insulin resistance. The challenge of developing a unifying theory that links seed oil consumption to metabolic disease and cancer is also identified.

    The energy model of insulin resistance: A unifying theory linking seed oils to metabolic disease and cancer · 2025 · DOI

  • further study of the effects of RBD seed oil consumption on cellular oxidative stress, - investigation of the role of mitochondrial adaptation to increased oxidative stress in the development of insulin resistance, - examination of the relationship between the Energy Model of Insulin Resistance and other chronic diseases

    The energy model of insulin resistance: A unifying theory linking seed oils to metabolic disease and cancer · 2025 · DOI

  • the correlation between muscular FNDC5 and serum irisin levels has limitations due to the temporal gap between irisin measurement and FNDC5 expression assessment

    Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin · 2024 · DOI

  • investigate the mechanisms underlying EX-induced cerebral BDNF expression, - explore the association between circulating irisin levels and hippocampal BDNF expression

    Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin · 2024 · DOI

  • the oral administration of sibutramine has a number of limitations, determined just in the greatest degree by its catecholaminergic effects, - the methods evaluating the metabolic activity of the tissue do not allow us to recognize all the subtle features of brown and beige adipose tissue, - no studies have reported on FXR agonists evaluating the expression of thermogenic genes based on adipose tissue biopsy data

    Brown and Beige Adipose Tissue: One or Different Targets for Treatment of Obesity and Obesity-Related Metabolic Disorders? · 2024 · DOI

  • further studies are required to understand the effects of different groups of thermogenesis-affecting drugs on brown and beige adipose tissue, - the role of EPO in regulating energy metabolism and its potential as a therapeutic target for obesity and metabolic disorders should be further investigated, - the development of new methods to distinguish between brown and beige adipose tissue is needed

    Brown and Beige Adipose Tissue: One or Different Targets for Treatment of Obesity and Obesity-Related Metabolic Disorders? · 2024 · DOI

  • Lack of a high-quality reference genome for a hibernating mammal - Limited understanding of the molecular mechanisms governing mammalian hibernation

    A telomere-to-telomere genome reveals arachidonic acid as a key regulator of hepatic lipid metabolism during hibernation · 2026 · DOI

  • Myonectin may regulate lipid metabolism and muscle mass after bariatric surgery and is an interesting candidate for future studies

    Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery · 2025 · DOI

  • Stress impacts our health and triggers physiological adaptations, yet the metabolic programs engaged during stress remain incompletely understood.

    Stress-induced Metabolic Remodeling of Adipose and Brain Tissue revealed by Positron Emission Tomography · 2026 · DOI

  • Although androgen signaling has been implicated in adipose tissue biology, its role in beige adipocyte remodeling and metabolic plasticity remains poorly understood.

    Androgen Receptor mediates beige adipocyte homeostasis and plasticity · 2026 · DOI

  • Underlying mechanisms and the role of muscle lipid distribution and composition on glucose metabolism remain unclear.

    Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals · 2025 · DOI

  • However, the importance of muscle BMAL1 in the development of metabolic diseases, such as diet-induced obesity (DIO), remains unclear.

    Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity · 2025 · DOI

  • However, the contribution of myokines to the dramatic changes in glucose homeostasis and muscle mass induced by bariatric surgery has not been established.

    Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery · 2025 · DOI

Most-cited papers in Adipose Tissue and Metabolism

Most recent work

Find a gap in your own Adipose Tissue and Metabolism sub-topic

This page shows what the Adipose Tissue and Metabolism literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
135 open questions have been extracted from the limitations and future-work passages of 427 Adipose Tissue and Metabolism papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.