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Open research questions in Alcohol Consumption and Health Effects

104 unresolved questions extracted from the limitations and future-work sections of 1,473 Alcohol Consumption and Health Effects papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • However, the contribution of impaired ALDH2 function to fibrotic susceptibility and the underlying regulatory molecules remains to be fully elucidated.

    Identification of mitochondria-associated hub genes related to alcohol-associated liver fibrosis progression in aldehyde dehydrogenase 2 deficiency · 2026 · DOI

  • Clinical evidence was limited to two small trials using Hovenia dulcis extracts, which demonstrated reductions in hangover severity and selected inflammatory markers but did not directly evaluate isolated DHM.

    Therapeutic Effects of Dihydromyricetin on Wholly Alcohol-Attributed Conditions: A Systematic Review · 2026 · DOI

  • In this study, alcohol consumption was measured via self-reported alcohol consumption behaviour, and self-reports tended to underestimate alcohol consumption due to recall bias. Since the study was performed at a health institution, diabetic patients who have severe alcohol use disorders may not visit the hospital. As an institution-based cross-sectional study, this work estimates prevalence and associations at a single point in time and therefore cannot establish causality or temporal sequence between factors and alcohol consumption. In addition, the outcome measurement tool (AUDIT, consider the past–12-month use) and other variables use different recall periods, introducing potential temporal misalignment.

    Alcohol consumption and associated factors among people with diabetes mellitus: a multicentre institution-based cross-sectional study · 2026 · DOI

  • 6 507 However, our study also unearthed certain limitations withinareas where 508 further clarification is warranted within the framework of the new 509 nomenclature.

    Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study · 2024 · DOI

  • Whether these changes predispose to greater liver pathology upon consumption of a high fat/high sugar diet that is more aligned with dietary intake of PWH and/or exposure to additional environmental factors warrants further investigation.

    Chronic binge alcohol mediated hepatic metabolic adaptations in SIV-infected female rhesus macaques · 2024 · DOI

  • AIMS: As the interactions of alcohol and HIV/SIV infection and their impact on liver metabolic homeostasis remain to be fully elucidated, this study aimed to determine alcohol-mediated hepatic adaptations of metabolic pathways in SIV/ART-treated female rhesus macaques fed a nutritionally balanced diet.

    Chronic binge alcohol mediated hepatic metabolic adaptations in SIV-infected female rhesus macaques · 2024 · DOI

  • AIMS: Liver transplantation (LT) for alcoholic liver disease (ALD) remains controversial yet following transplantation outcomes for patients with this disease are generally similar to patients transplanted for other types of liver diseases.

    Post-transplant Outcomes of Persons Receiving a Liver Graft for Alcoholic Liver Disease · 2017 · DOI

  • Subjects who reported 30-day abstinence but with quantifiable PEth either reported heavy drinking within the past 6 weeks or had data that suggested underreported drinking.

    Validation of Blood Phosphatidylethanol as an Alcohol Consumption Biomarker in Patients with Chronic Liver Disease · 2014 · DOI

  • FAEES activity is the most widely studied and has been purified from several tissues and shown to be associated with several well-known enzymes, while the identity of enzymes possessing AEAT activity remains unknown.

    Synthesis of fatty acid ethyl esters in mammalian tissues after ethanol exposure: a systematic review of the literature · 2013 · DOI

  • AIMS: As recent conflicting reports describe a genetic association between both the C- and the T-alleles of the dopamine D2 receptor (DRD2) C957T polymorphism (rs6277) in alcohol-dependent subjects, our aim was to examine this polymorphism and TaqIA (rs1800497) in Australian alcohol-dependent subjects.

    DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence · 2012 · DOI

  • AIMS: Dangerous alcohol consumption practices are common in adolescents, yet little is known about their consequences on attainment of peak bone mass and long-term skeletal integrity.

    Long-Term Modulations in the Vertebral Transcriptome of Adolescent-Stage Rats Exposed to Binge Alcohol · 2010 · DOI

  • AIMS: Despite the large number of suicides that occur with intoxication, little is known about the unique predictors of suicide after alcohol consumption.

    Clinical and Genetic Risk Factors for Suicide under the Influence of Alcohol in a Polish Sample · 2009 · DOI

  • Additional studies of alcohol and injury in general populations that take into account the intensity of exposure to alcohol before the event, as well as recall bias by eliciting data on the proximity of the event to the time of the respondent interview, are necessary for determining unbiased estimates of the attributable fraction of alcohol in injury morbidity.

    Alcohol-Attributable Fraction for Injury in the U.S. General Population: Data From the 2005 National Alcohol Survey · 2008 · DOI

  • However, it remains unclear whether such patterns truly reflect secular trends or are confounded by age-dependent factors such as differential recall, differential mortality, and other effects.

    Secular Trends in the Lifetime Prevalence of Alcohol Dependence in the United States: A Re‐evaluation · 2008 · DOI

  • A less expensive and more easily used measure of LR, the retrospective Self-Rating of the Effects of Alcohol (SRE) questionnaire, also relates to alcohol intake and problems but has not been evaluated for its ability to predict alcohol-related problems 5 years later.

    The Ability of the Self-Rating of the Effects of Alcohol (SRE) Scale to Predict Alcohol-Related Outcomes Five Years Later · 2007 · DOI

  • BACKGROUND: There is evidence of a U-shaped association between alcohol consumption and physical health outcomes in older people, such that moderate drinking is associated with better outcomes than abstinence or heavy drinking, but whether moderate drinking in older people is associated with better cognition and mental health than non-drinking has not been explored.

    Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence · 2007 · DOI

  • However, although increasing age has also been suggested to elevate serum GGT activities, the magnitude of such effects on GGT in the assessment of ethanol intake have remained poorly defined.

    AGE-RELATED CHANGES ON SERUM GGT ACTIVITY AND THE ASSESSMENT OF ETHANOL INTAKE · 2006 · DOI

  • As conflicting data were published regarding the influence of age and gender on the activity of alcohol dehydrogenase (ADH) in human gastric mucosa, the present study aimed at the investigation of these and other potentially confounding factors (alcohol consumption, smoking, drug intake) on its activity in a Caucasian population.

    GASTRIC ALCOHOL DEHYDROGENASE ACTIVITY IN MAN: INFLUENCE OF GENDER, AGE, ALCOHOL CONSUMPTION AND SMOKING IN A CAUCASIAN POPULATION · 2002 · DOI

  • BACKGROUND: Estimates of the performance of carbohydrate deficient transferrin (CDT) and gamma glutamyltransferase (GGT) as markers of alcohol consumption have varied widely.

    CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project · 2002 · DOI

  • Oxidation of ethanol via alcohol dehydrogenase (ADH) explains various metabolic effects of ethanol but does not account for the tolerance and a number of associated disorders that develop in the alcoholic.

    Microsomal Ethanol‐Oxidizing System (MEOS): The First 30 Years (1968‐1998)–A Review · 1999 · DOI

  • The proportion of alcohol eliminated by gastric first-pass metabolism also remains controversial (Sato and Kitamura 1996); compared with hepatic alcohol degradation, gastric first-pass metabolism seems to be quantitatively important only at low alcohol concentrations.

    Alcohol Absorption, Metabolism, and Production in the Gastrointestinal Tract · 1997

  • These results indicate that hepatic ALDH2 activity is lacking completely, and metabolism of Ac-CHO in the liver is severely impaired in the homozygotes of the mutant ALDH2 genes.

    Acetaldehyde Metabolism in Different Aldehyde Dehydrogenase‐2 Genotypes · 1991 · DOI

  • The effects of scheduling the availability of ethanol on its voluntary consumption by the selectively bred alcohol-preferring P rats were examined under three conditions: unrestricted 24 hr/day access (Condition A), access limited to a continuous 4 hr/day (Condition B), and access limited to 1 hr every 3 hr, 4 times/day (Condition C).

    Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats · 1986 · DOI

  • However, how changes in alcohol consumption affect fibrosis progression in MASLD and MetALD remains unclear.

    Comparing the Effect of Changes in Alcohol Intake on Liver Fibrosis Risk Scores Among Patients With Two Distinct Types of Steatotic Liver Disease · 2026 · DOI

  • Emerging evidence suggests metabolism-disrupting agents (MDAs) may synergistically amplify alcohol-induced hepatotoxicity, yet population-level evidence remains limited.

    The hidden effects of metabolism-disrupting agents on alcohol-related liver disease risk: an integrated epidemiological, machine learning, and network toxicology Analysis · 2026 · DOI

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104 open questions have been extracted from the limitations and future-work passages of 1,473 Alcohol Consumption and Health Effects papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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