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Open research questions in Antimicrobial Resistance in Staphylococcus

130 unresolved questions extracted from the limitations and future-work sections of 727 Antimicrobial Resistance in Staphylococcus papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The paper identifies a gap in the understanding of the biological characteristics of menadione-dependent Staphylococcus aureus SCVs. It also highlights the need to investigate the effects of heme and menadione on SCV biofilm formation.

    Biological characteristics of a menadione-dependent Staphylococcus aureus small colony variant (SCV) from bovine mastitis and heme promotion of biofilm formation · 2026 · DOI

  • The study identifies a gap in the understanding of the genomic profiles and antimicrobial susceptibility of Staphylococcus aureus isolates from food products in Northern Kazakhstan. The study also highlights the need for whole-genome sequencing to analyze the isolates.

    Whole-genome analysis and phenotypic antimicrobial resistance of Staphylococcus aureus isolated from foods in Northern Kazakhstan · 2026 · DOI

  • The study identifies the challenge of promoting antimicrobial resistance due to unnecessary use of anti-MRSA therapy in low-risk patients. The study highlights the need for improved clinical prediction tools and rapid diagnostics to inform decisions regarding MRSA coverage in empiric regimens. The study notes the challenge of making treatment decisions in the emergency department, where clinical decisions must often be made before culture results or prior infection history are available.

    Factors Associated with Methicillin-Resistant Staphylococcus aureus Infection Among Patients with Sepsis Presenting to Emergency Departments: A Nationwide Multicenter Cohort Study · 2026 · DOI

  • Further studies are needed to validate the findings, - Research on rapid diagnostics to inform decisions regarding MRSA coverage is needed, - Studies on the impact of antimicrobial stewardship efforts on MRSA infection are required

    Factors Associated with Methicillin-Resistant Staphylococcus aureus Infection Among Patients with Sepsis Presenting to Emergency Departments: A Nationwide Multicenter Cohort Study · 2026 · DOI

  • No human participants or identifiable personal data, - No information for S. hominis in the Transporter Classification Database, - Limited to analysis of bacterial cultures

    Occurrence, variability and evolutionary relations of efflux pump determinants across five pathogenic Staphylococcus species · 2026 · DOI

  • Further analysis of efflux pump genes, - Investigation of putative MDR transporters, - Study of efflux-mediated resistance in other staphylococci

    Occurrence, variability and evolutionary relations of efflux pump determinants across five pathogenic Staphylococcus species · 2026 · DOI

  • aureus pneumonia encompasses compositional heterogeneity with prognostic implications remains unknown.

    Microbiome Profiling Reveals Prognostic Heterogeneity in Staphylococcus aureus Pneumonia · 2026 · DOI

  • Little is known about the source of those genes or the pathway by which they entered human-associated strains.

    Novelty, diversity, and genetic dark matter in enterococci of invertebrates · 2026 · DOI

  • Our findings also highlight the therapeutic potential of lytic phages against virulent CoNS species and support further investigation of phage therapy for chronic staphylococcal infections.

    First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment · 2026 · DOI

  • ABSTRACT Staphylococcus felis is a coagulase-negative Staphylococcus (CoNS) primarily associated with the feline microbiota and only rarely reported in human disease.

    First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment · 2026 · DOI

  • pseudintermedius pathogenesis, effective immunoprophylaxis remains elusive because of bacterial antigenic diversity.

    The dynamic interplay between Staphylococcus pseudintermedius and canine immunity: mechanisms of pathogenesis, evasion, and vaccination perspectives · 2026 · DOI

  • Furthermore, we suggest gaps that warrant further research and outline strategies for immunotherapeutics and vaccines against canine staphylococcal infections.

    The dynamic interplay between Staphylococcus pseudintermedius and canine immunity: mechanisms of pathogenesis, evasion, and vaccination perspectives · 2026 · DOI

  • It remains elusive whether the pathway of internalization can affect the intracellular fate of the bacteria.

    A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus · 2026 · DOI

  • Despite the vast geographical expanse and diverse demographics of the Kingdom of Saudi Arabia and the broader West Asia region, the population diversity of MRSA in hospitals in these areas remains underexplored.

    Methicillin-resistant Staphylococcus aureus in Saudi Arabia: genomic evidence of recent clonal expansion and plasmid-driven resistance dissemination · 2025 · DOI

  • However, further functional consequences of Efb-C binding to C3b remain unexplored.

    The C-terminal domain of Staphylococcus aureus Efb recruits FHR-2 to C3b, synergistically inhibiting the terminal complement pathway · 2025 · DOI

  • Data on MRSA in retail foods from the United Arab Emirates (UAE) remain scarce, despite the country's heavy reliance on diverse food supply chains.

    Prevalence, antimicrobial resistance, and distribution of toxin genes in methicillin-resistant Staphylococcus aureus from retail meat and fruit and vegetable cuts in the United Arab Emirates · 2025 · DOI

  • However, how PBPs-which typically use D-Ala-D-Ala as a substrate-adapt to recognize D-Ala-D-Lac remains unclear.

    Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis · 2025 · DOI

  • Abstract Background The optimal pharmacokinetic and pharmacodynamic (PK/PD) parameters of vancomycin that can improve outcomes in enterococcal infections remain controversial.

    Impact of vancomycin area under the curve in early or later phase on efficacy and nephrotoxicity in patients with enterococcal bloodstream infections: a multicenter study · 2025 · DOI

  • BACKGROUND: The optimal vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets for successful treatment of enterococcal infections remain controversial.

    Association of vancomycin trough levels, AUC and AUC/MIC ratios with clinical outcomes in patients with enterococcal bacteremia: a prospective cohort study · 2025 · DOI

  • However, to date, no data are available comparing the outcomes of patients treated with vancomycin or linezolid for these infections.

    Vancomycin versus linezolid for treatment of staphylococcal-associated central nervous system infections · 2025 · DOI

  • Unlike other studies, a higher prevalence of MRSA was observed among female patients, warranting further investigation to identify potential underlying factors.

    Prevalence and associated factors of methicillin-resistant and vancomycin-susceptible Staphylococcus aureus among clinical isolates at Hawassa university comprehensive specialized hospital, Ethiopia, 2019–2023 · 2025 · DOI

  • There is limited data on the prevalence and trends of methicillin and vancomycin resistant S.

    Prevalence and associated factors of methicillin-resistant and vancomycin-susceptible Staphylococcus aureus among clinical isolates at Hawassa university comprehensive specialized hospital, Ethiopia, 2019–2023 · 2025 · DOI

  • However, genomic epidemiology and determinants influencing transmission of ear infections associated MRSA (EIA-MRSA) in community remain unknown.

    Genomic insights into the spread of methicillin-resistant Staphylococcus aureus involved in ear infections · 2025 · DOI

  • Limited evidence exists on the extent and appropriateness of vancomycin utilization in Ethiopian hospitals.

    Evaluation of vancomycin utilization in medical and pediatric wards: a retrospective cross-sectional study at Bule Hora University Teaching Hospital, Ethiopia · 2025 · DOI

  • The past decade has seen an increase in the prevalence of sequence type (ST) 45 methicillin-resistant Staphylococcus aureus (MRSA), yet the underlying drivers for its emergence and spread remain unclear.

    Emergence and clonal expansion of a qacA-harbouring sequence type 45 lineage of methicillin-resistant Staphylococcus aureus · 2024 · DOI

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130 open questions have been extracted from the limitations and future-work passages of 727 Antimicrobial Resistance in Staphylococcus papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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