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Open research questions in Antioxidant Activity and Oxidative Stress

108 unresolved questions extracted from the limitations and future-work sections of 400 Antioxidant Activity and Oxidative Stress papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Although the current study was performed important information about the properties of MDA and the parameters that may affect the formation/detection of MDA in complex biological polymeric materials and food of inositolhexakisphosphate (IHP) in this system is a basis for further research of IHP in relation to oxidative processes and reactions with MDA.

    pH Dependence of the Formation of Malondialdehyde (MDA) in the Reaction of 2-Thiobarbituric Acid (2-TBA) with Local Yoghurt (Nunu) · 2026 · DOI

  • There have been no studies examining the effects of tocotrienols on cognitive function when delivered as a stand-alone intervention. The study aims to investigate the effects of tocotrienols on cognitive function in adults with subjective memory complaints.

    An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial · 2025 · DOI

  • Research is needed to elucidate the underlying mechanisms and clinical implications of oxidative stress modulation in the context of oral cancer. Further investigation is required to understand the precise mechanisms underlying melatonin's anticancer effects. Comprehensive approaches addressing the multifaceted interactions between oxidative stress and other risk factors are warranted for effective prevention and treatment strategies.

    Oxidative Stress in the Pathogenesis of Oral Cancer · 2024 · DOI

  • the underlying mechanisms of oxidative stress in oral cancer are not fully understood. the therapeutic efficacy of antioxidants in halting cancer progression is debated. there is a need for personalized therapeutic strategies for patients with oral cancer.

    Oxidative Stress in the Pathogenesis of Oral Cancer · 2024 · DOI

  • Labeled content varied widely; vitamin B12 ranged from 100% to 33,333% DV (median 408%).

    Marked heterogeneity in micronutrient composition of multivitamin-mineral supplements · 2026 · DOI

  • Despite rising patient use, Nigerian healthcare professionals’ attitudes and knowledge remain unclear.

    Assessment of the Use of Nutraceuticals Among Health Practitioners in a Tertiary Hospital in Enugu State, Nigeria · 2026 · DOI

  • Blakeslea trispora is a well-known fungal producer of natural β-carotene; however, its performance on low-cost industrial waste streams remains underexplored.

    Sustainable waste-based fermentation for enhanced β-carotene biosynthesis by Blakeslea trispora and functional evaluation of the extracted pigment · 2026 · DOI

  • POR1 and POR2 are key genes in chlorophyll biosynthesis yet the contribution of the chlorophyll biosynthetic pathway to tocopherol biosynthesis is still not understood.

    Total tocopherol levels in maize grain depend on chlorophyll biosynthesis within the embryo · 2025 · DOI

  • However, future research is required to substantiate this study’s results and examine the potential mechanisms of action.

    An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial · 2025 · DOI

  • Further studies on the purification and application of carotenoids are recommended.

    Gas chromatography-mass spectrometry characterization of carotenoids produced by yeasts isolated from edible fruits and vegetables marketed in Osogbo metropolis, Southwest Nigeria · 2025 · DOI

  • Background: Limited evidence exists regarding the association between oxidative stress induced by dietary and lifestyle factors and cardiovascular diseases (CVDs).

    Dietary and lifestyle oxidative balance scores and their impact on cardiovascular diseases: exploring the mediating influence of hepatic function and blood lipid levels · 2025 · DOI

  • However, current evidence remains insufficient to establish a definitive relationship between circulating vitamin E levels, body fat content, and their influence on metabolic health.

    Nutritional Status of Vitamin E and Its Association with Metabolic Health in Adults · 2025 · DOI

  • Further research on diet natural antioxidant supplementation needs to be continued.

    Changes in Oxidative Stress, Inflammatory Markers, and Lipid Profile After a 6-Week High-Antioxidant-Capacity Dietary Intervention in CVD Patients · 2025 · DOI

  • In this study, an additional 100, 200, and 400 mg/kg lutein and astaxanthin were added in hen diets to explore the effects of high-dose lutein and astaxanthin on egg quality, egg production, and carotenoid deposition in eggs, which remains unclear.

    Lutein and Astaxanthin Supplementation Induce Competitive Inhibition of Carotenoid Deposition in Egg Yolk · 2025 · DOI

  • However, it remains unclear to what extent carotenoids are associated with specific leukocyte subsets or other inflammatory markers.

    Plasma carotenoids are inversely correlated with granulocyte counts and soluble inflammatory markers in a middle-aged population: a cross-sectional study with mediation analysis · 2025 · DOI

  • Therapeutic effect of astaxanthin in OPMDs and oral squamous cell carcinoma (OSCC) models is confirmed, but the relationship between the anti‐cancer ability of astaxanthin and its DNA methylation regulation ability remains unclear.

    Astaxanthin Increases Tumor Suppressor Gene Expression and Affects Cellular Biological Behavior in Oral Dysplastic Keratinocytes by Regulating DNA Methylation · 2024 · DOI

  • However, the underlying mechanisms in the formation of yellow cotyledons and leaves remain unclear.

    Effects of different light intensity on leaf color changes in a Chinese cabbage yellow cotyledon mutant · 2024 · DOI

  • However, there is limited research on the association between OBS and colorectal cancer (CRC), its subsites, and complications.

    Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences · 2024 · DOI

  • The most abundant form of vitamin E, namely α-tocopherol, has high antioxidant properties and biological activity; however, its effect on osteoporosis has not been well studied in humans.

    Association between dietary vitamin E and osteoporosis in older adults in the United States · 2024 · DOI

  • Background Although some evidence suggests a role for vitamin C intake in thyroid diseases, the complex interplay between vitamin C intake and thyroid function remains incompletely understood.

    Association between vitamin C intake and thyroid function among U.S. adults: a population-based study · 2024 · DOI

  • However, association between OBS and MetS and its components has not been reported.

    Association between oxidative balance score and metabolic syndrome and its components in US adults: a cross-sectional study from NHANES 2011–2018 · 2024 · DOI

  • This broad overview of RDP studies on Pycnogenol® in different health domains can be used as a basis for further research on applications and mechanisms of this unique French maritime pine bark extract.

    Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies · 2024 · DOI

  • Current trial evidence on lutein bioavailability is contradictory, and the interactions of dietary intervention with host-related factors remain elusive.

    Effect of supplementation with lutein, zeaxanthin, and omega-3 fatty acids on macular pigment and visual function in young adults with long-term use of digital devices: study protocol for a randomized double-blind placebo-controlled study · 2024 · DOI

  • However, the long-term prognostic implications of serum vitamin A in patients with NAFLD remain underexplored.

    U-shaped association of serum vitamin A concentrations with all-cause mortality in patients with NAFLD: results from the NHANES database prospective cohort study · 2024 · DOI

  • Background: Oxidative stress is a known pathogenic mechanism in cardiovascular disease (CVD), yet the association between dietary antioxidants and CVD in the general population remains underexplored.

    Association of composite dietary antioxidant index with cardiovascular disease in adults: results from 2011 to 2020 NHANES · 2024 · DOI

Most-cited papers in Antioxidant Activity and Oxidative Stress

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108 open questions have been extracted from the limitations and future-work passages of 400 Antioxidant Activity and Oxidative Stress papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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