Science AI Journal
Medicine · Research topic

Open research questions in Blood Coagulation and Thrombosis Mechanisms

94 gap statements mined from Blood Coagulation and Thrombosis Mechanisms papers in our 4.5M-paper local library, which holds 424 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

What the literature leaves open

  • However, the benefit of thrombectomy in children with LVO and mild presenting symptoms remains uncertain.

    Thrombectomy for Pediatric Large Vessel Occlusion Stroke With Mild Presenting Symptoms · 2026 · DOI

  • Variants of methylenetetrahydrofolate reductase ( MTHFR ) and of the plasminogen activator inhibitor-1 gene ( SERPINE1 /PAI-1) may increase this risk, but data from Central Asian populations are scarce.

    MTHFR (rs1801133) and SERPINE1/PAI-1 (−675 4G/5G) gene polymorphisms and their association with spontaneous abortion and missed pregnancy in an ethnic Uzbek population: a case–control study · 2026 · DOI

  • While existing structures have revealed inactive and active conformations, the ligand-dependent conformational energy landscape governing PAR1 activation remains poorly understood.

    Energy Landscape Sampling Reveals Ligand-Dependent Structural Dynamics of the Protease-Activated Receptor 1 · 2026 · DOI

  • CONCLUSIONS: High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce.

    ASH/ISTH 2026 guidelines for anticoagulant prophylaxis in pediatric patients at risk of venous thromboembolism · 2026 · DOI

  • High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce.

    ASH/ISTH 2026 guidelines for anticoagulant prophylaxis in pediatric patients at risk of venous thromboembolism · 2026 · DOI

  • Age and sex have been shown to affect TG parameters, but no consensus has been reached on the subject.

    Age- and sex-dependency of thrombin generation parameters in the general Italian population: the Moli-sani study · 2025 · DOI

  • BACKGROUND: Thromboprophlyaxis for the prevention of venous thromboembolism during pregnancy and the puerperium is widespread, but there is a lack of evidence on the risks and benefits of thromboprophylaxis within this population.

    What influences women’s decisions to participate in trials for prevention of venous thromboembolism during pregnancy and the puerperium: a qualitative study · 2025 · DOI

  • There are relatively few reports on fetal Bartter syndrome, but it has been documented that the condition can increase the incidence of prematurity and hypovolemia.

    Fetal umbilical vein thrombosis associated with fetal bartter syndrome: an unusual case report and literature review · 2025 · DOI

  • While many of the existing data stem from studies in arterial ischemic stroke, functional outcomes in hemorrhagic stroke, and particularly pediatric intracerebral hemorrhage, remain largely understudied.

    Pediatric Intracerebral Hemorrhage Management—Consensus Statement of the International Pediatric Stroke Organization—Part 2: Outcomes, Rehabilitation, and Transition to Adulthood · 2025 · DOI

  • Further experimental, translational, and epidemiologic studies are warranted to delineate underlying mechanisms and to evaluate thromboembolic safety in pharmacologic IL-6 signaling inhibition.

    Genetic Downregulation of Interleukin‐6 Signaling, Coagulation Function, and Risk of Thromboembolic Disease · 2025 · DOI

  • BACKGROUND: Although genetic evidence supports IL-6 (interleukin-6) signaling inhibition as protective against atherosclerotic disease, its potential effects on thromboembolic outcomes are not well established.

    Genetic Downregulation of Interleukin‐6 Signaling, Coagulation Function, and Risk of Thromboembolic Disease · 2025 · DOI

  • ABSTRACT: Risk factors for recurrent venous thromboembolism (VTE) in children are poorly understood, and concerns remain about the risks of anticoagulant therapy in children.

    Recurrent thrombosis and major bleeding in children treated for VTE · 2025 · DOI

  • Epidemiological data on venous thromboembolism (VTE) in children and adolescents is sparse and available primarily for the USA.

    Burden and management of venous thromboembolism in children and adolescents (2004–2023): a Swiss nationwide epidemiological study · 2025 · DOI

  • The low number of epidemiological studies suggests that further research of this type is needed to fully understand the incidence and risk factors in young stroke.

    An international perspective on young stroke incidence and risk factors: a scoping review · 2024 · DOI

  • Background: The mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.

    Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C · 2024 · DOI

  • However, it remains unclear which reagent is better suited for the detection of APC pathway resistance.

    Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C · 2024 · DOI

  • Cysteine proteases calpains contribute to heart failure (HF), but it remains unknown whether their inhibition provides any benefit compared to standard pharmacological treatment for HF.

    Efficacy of a cysteine protease inhibitor compared with enalapril in murine heart failure models · 2024 · DOI

  • However, data regarding the association with early stent thrombosis (ST) is sparse.

    Markers of coagulation and early coronary stent thrombosis · 2024 · DOI

  • The interaction between complement and coagulation activation might be relevant for clinical outcomes in STEMI patients and warrants further investigation.

    Combined activation of complement and coagulation is associated with myocardial injury in ST-elevation myocardial infarction · 2024 · DOI

  • We hypothesize that CFD can be an important modulator of the inflammation-remodeling cascade post MI, but the specific mechanism remains elusive.

    Complement factor D deficiency ameliorates adverse cardiac remodelling by inhibiting C5a-C5aR mediated ISGs+ neutrophil activation post myocardial infarction · 2024 · DOI

  • However, the role of APC and APC-biased PAR1 signaling in thrombin generation, inflammation, and endothelial activation in SCD remains unexplored.

    Biased agonism of protease-activated receptor-1 regulates thromboinflammation in murine sickle cell disease · 2024 · DOI

  • However, little is known regarding the release mechanism and properties of TM536.

    Thrombomodulin (p.Cys537Stop) is released from cells by an unusual membrane insertion/leakage mechanism · 2024 · DOI

  • In vitro assays have established that therapeutic heparins promote the anticoagulant function of AT by binding D-helix and activating the serpin, however, the contribution of vascular GAGs to D-helix-dependent anticoagulant function of AT has remained poorly understood in vivo.

    Physiological significance of antithrombin D-helix interaction with vascular GAGs · 2024 · DOI

  • Although 7% of the population is homozygous for the G haplotype (F5-G/G), the underlying mechanism of VTE protection is poorly understood.

    The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding · 2024 · DOI

  • Further studies are needed to validate the study's findings and to develop personalized anticoagulation strategies for postpartum VTE patients. Research is needed to examine the long-term outcomes of postpartum VTE patients treated with LMWH. Studies are needed to investigate the cost-effectiveness of personalized anticoagulation strategies for postpartum VTE patients.

    Monitoring anti-Xa levels and thromboelastography in puerperal venous thromboembolism: a prospective cohort study · 2026 · DOI

Most-cited papers in Blood Coagulation and Thrombosis Mechanisms

Most recent work

Find a gap in your own Blood Coagulation and Thrombosis Mechanisms sub-topic

This page shows what the Blood Coagulation and Thrombosis Mechanisms literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 4.5M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,595 open questions
Substance Abuse Treatment and Outcomes
2,053 open questions
Dementia and Cognitive Impairment Research
1,270 open questions
Smoking Behavior and Cessation
1,068 open questions
Physical Activity and Health
1,057 open questions
Innovations in Medical Education
1,018 open questions
Schizophrenia research and treatment
1,005 open questions
Attention Deficit Hyperactivity Disorder
998 open questions
94 gap statements have been mined from Blood Coagulation and Thrombosis Mechanisms papers in our 4.5M-paper local library, which holds 424 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.