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Open research questions in Blood Pressure and Hypertension Studies

372 unresolved questions extracted from the limitations and future-work sections of 1,817 Blood Pressure and Hypertension Studies papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study only included patients with a confirmed diagnosis of primary hypertension, - The study only included patients who established a specialized hypertension management archive in a primary healthcare institution in Quzhou, - The study had a limited sample size of 1310 participants

    Impact of a free medication policy on blood pressure among older patients with hypertension: an interrupted time series analysis · 2026 · DOI

  • The gap in the literature is the lack of studies evaluating the impact of a free medication policy on blood pressure control among older hypertensive patients. Prior studies have not controlled for seasonal fluctuations and pre-existing trends.

    Impact of a free medication policy on blood pressure among older patients with hypertension: an interrupted time series analysis · 2026 · DOI

  • Overburdened health systems in low-income countries. The paucity of doctors and lack of affordable essential antihypertensive medications. Patient-level factors including low level of awareness of deleterious effects of uncontrolled blood pressure and various traditional beliefs.

    Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana · 2026 · DOI

  • further studies could investigate the long-term effects of the intervention, - research could explore the application of the intervention in different settings, - studies could examine the cost-effectiveness of the intervention

    Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana · 2026 · DOI

  • The biological mechanisms underlying interindividual variability in blood pressure regulation and hypertension susceptibility remain incompletely understood. Genetic factors contributing to blood pressure heritability are not fully elucidated.

    A CYP11B2 variant (rs7831617) is associated with lower blood pressure and a reduced risk of incident hypertension · 2026 · DOI

  • The study faces challenges in terms of the underrepresentation of randomized controlled trials among older adults. The study needs to address the inconsistency in current guidelines on blood pressure targets for older patients. The study requires the use of electronic medical records to emulate a target trial.

    The optimal blood pressure target in old and very old patients with hypertension · 2026 · DOI

  • Further studies are needed to confirm the findings, - Investigation of the optimal BP target in different populations, - Evaluation of the long-term effects of the lower BP target

    The optimal blood pressure target in old and very old patients with hypertension · 2026 · DOI

  • There is a need to examine the prevalence and risk factors of hypertension in Bangladesh. There is a lack of studies using machine learning and deep learning approaches to predict hypertension risk in Bangladesh. The study aims to fill this gap by analyzing cross-sectional data from the 2022 Bangladesh Demographic and Health Survey.

    Machine learning and deep learning–based prediction of hypertension and analysis of its major risk factors in Bangladesh · 2026 · DOI

  • Further studies are needed to confirm the association between rs7831617 and hypertension risk - Research on the biological mechanisms underlying the association between rs7831617 and blood pressure regulation is needed - Studies on the clinical significance of the small differences in blood pressure at the individual level are required

    A CYP11B2 variant (rs7831617) is associated with lower blood pressure and a reduced risk of incident hypertension · 2026 · DOI

  • How patients' health beliefs translate into adherence and blood pressure control in rural settings is poorly understood.

    Health beliefs, medication adherence, and blood-pressure control in rural Bangladeshi hypertension: an exploratory sequential mixed-methods study · 2026 · DOI

  • Although the prevalence of HTN is increasing in Saudi Arabia, there have been limited studies and updates of national-level numbers.

    Descriptive analysis of hypertension in Saudi Arabia: a national population health perspective (hypertension in Saudi Arabia) · 2026 · DOI

  • Conclusions More than 7 million US adults with hypertension require an extra-large BP cuff; the substantially higher cost of extra-large cuff-compatible devices represents an important and underrecognized barrier to accurate home BP monitoring.

    Extra-Large Blood Pressure Cuff Need and Cost Burden in United States Adults with Hypertension · 2026 · DOI

  • The causal relationships between attention-deficit/hyperactive disorder (ADHD) and vascular risk factors remain insufficiently understood.

    Interplay between attention-deficit/hyperactivity disorder, educational attainment, and vascular risk factors: Insights from Mendelian randomization analyses · 2025 · DOI

  • However, limited research has examined whether general practitioners (GPs) share this view or have specific prescribing preferences.

    General practitioners’ perspectives, preferences, and practices in prescribing antihypertensive medication in primary, uncomplicated hypertension · 2025 · DOI

  • A comprehensive approach is warranted, including strategies to enhance adherence, early diagnosis, personalized treatment, and simplified medication regimens.

    Medication adherence and blood pressure control in treated hypertensive patients: first follow-up findings from the PREDIcT-HTN study in Northern Bangladesh · 2025 · DOI

  • Background: Despite the already comprehensive epidemiological evidence concerning pre-hypertension, high-normal blood pressure, and hypertension, the influence of gender differences within this context remains inadequately explored.

    Sex-specific differences in the relationship between the atherogenic index and hypertension in middle-aged and elderly Chinese · 2025 · DOI

  • Despite its significance, limited information is available regarding patients' awareness of hypertension complications and associated factors in the study area.

    Awareness of hypertension-related complications and its determinants among adult hypertensive patients in Ethiopia · 2025 · DOI

  • However, the specific contribution of high BMI to the burden of HHD remains unclear.

    Global burden of hypertensive heart disease attributable to high body mass index from 1990 to 2021: a multidimensional analysis and public health response · 2025 · DOI

  • Evidence is lacking for guiding optimal combination hypertension therapy in South Asian patients.

    Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial · 2025 · DOI

  • Future research should investigate the impact of a multi-level intervention on hypertension management in Ghana.

    A Qualitative Study on the Barriers and Enablers to Effective Hypertension Management in Ghana · 2025 · DOI

  • Conclusions Even though antihypertensive medications showed varying occurance of intradialytic hypertension, the results are inconclusive due to large confidence intervals that could be due to the presence of colliniarity between the variables.

    Association of intradialytic hypertension and antihypertensive medication use in patients undergoing maintenance hemodialysis: a prospective observational study · 2025 · DOI

  • OBJECTIVE: A significant correlation has been discovered between illness perception and quality of life, but the relationships among illness perception, medication experience, and quality of life remain to be confirmed.

    The relationship between illness perception and quality of life among Chinese rural elderly patients with hypertension: the mediating role of medication experience · 2025 · DOI

  • However, the associations of the TyG index and its combination with blood pressure (BP) on cardiovascular and all-cause mortality in hypertension remain unclear.

    The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study · 2024 · DOI

  • Background: The level at which cumulative blood pressure (BP) can increase the risk of ASCVD in different age groups remains unclear.

    Effect of 10-year cumulative blood pressure exposure on atherosclerotic cardiovascular disease of different age groups: kailuan cohort study · 2024 · DOI

  • However, the association between participation in the POSBINDU program with increasing knowledge, attitude, and practice of hypertension has not been widely assessed.

    Differences in knowledge, attitude, and practice regarding hypertension by access to a community-based screening program (POSBINDU): A cross-sectional study from four districts in Indonesia · 2024 · DOI

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372 open questions have been extracted from the limitations and future-work passages of 1,817 Blood Pressure and Hypertension Studies papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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