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Open research questions in Blood Pressure and Hypertension Studies

781 gap statements mined from Blood Pressure and Hypertension Studies papers in our 7.9M-paper local library, which holds 4,639 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The lack of clinical trials in paediatric patients and the scarcity of appropriate pharmaceutical formulations. The limited use of combination therapies in paediatric populations due to regulatory and formulation challenges. Disparities in paediatric participation in clinical trials during the antihypertensive era.

    Combination therapy and formulation challenges in paediatric hypertension: an unmet need · 2026 · DOI

  • The study highlights the challenge of limited external validation in diverse populations, which may differ substantially from derivation cohorts. The study notes the challenge of inadequate calibration assessment and reporting, which can limit the clinical utility of the models.

    Prognostic Models for Incident Hypertension: Time to Move from Development to Implementation—An Umbrella Review · 2026 · DOI

  • The study highlights the need for further research to address these challenges and provide more accurate estimates of the prevalence of nocturnal and isolated nocturnal hypertension.

    Prevalence of nocturnal and isolated nocturnal hypertension in population-based studies: a systematic review and meta-analysis · 2026 · DOI

  • The need for further research to understand the pathophysiological mechanisms underlying these risk factors. The challenge of integrating these factors into clinical practice and risk assessment tools.

    Non-Traditional Cardiovascular Risk Factors: Tailored Assessment and Clinical Implications · 2025 · DOI

  • One challenge is the lack of representation of women in clinical and epidemiological studies. Another challenge is the need to control for potential confounding influences, such as demographic, anthropometric, and socioeconomic covariates. A technical challenge is the integration of data from three independent sources, requiring standardization of variables and exclusion of outliers.

    Sex-Specific Patterns in Blood Pressure and Vascular Parameters: The MUJER-EVA Project · 2025 · DOI

  • The precise prevalence of INH remains incompletely understood due to variability in study populations and methodologies. There is a need to assess the relationship between INH and kidney disease progression in a large cohort of hypertensive patients.

    Relationships of Isolated Nocturnal Hypertension with Glomerular Filtration Rate and Albuminuria · 2025 · DOI

  • There is a paucity of studies that have applied digital blood pressure intervention models to hemodialysis patients. Digital blood pressure management has been underused in this population. There is a need for effective and widely used approaches to manage blood pressure in hemodialysis patients.

    Efficacy of a Web-Based Home Blood Pressure Monitoring Program in Improving Predialysis Blood Pressure Control Among Patients Undergoing Hemodialysis: Randomized Controlled Trial · 2024 · DOI

  • Regular blood pressure measurement among healthcare professionals was insufficient.

    Hypertension and Heart: Are We Aware? Hypertension Awareness and Cardiovascular Risk Profile in Health Care Professionals · 2026 · DOI

  • Whether South Africa's 1994 political transition interrupted this intergenerational transmission remains unknown.

    Intergenerational hypertension transmission before and after South Africa's democratic transition · 2026 · DOI

  • However, the association between the nondipper heart rate (NDHR) and the risk of LVH remains unclear.

    Synergistic impact of nondipper heart rate and blood pressure on left ventricular hypertrophy in essential hypertension · 2026 · DOI

  • The Chinese visceral adiposity index (CVAI) has been shown to be a practical indicator of visceral adiposity, but its association with prevalent hypertension in older adults remains unclear.

    Association between Chinese visceral adiposity index and prevalent hypertension among older adults in rural China: A cross-sectional study · 2026 · DOI

  • However, whether RC contributes to the transition from prehypertension to clinical hypertension remains unclear.

    Remnant cholesterol predicts progression from prehypertension to incident hypertension: Evidence from a prospective cohort study and Mendelian randomization analysis · 2026 · DOI

  • However, the role of diastolic blood pressure variability (DBPV) in predicting these outcomes, particularly in comparison to systolic blood pressure variability (SBPV), remains unclear.

    Diastolic Blood Pressure Variability Predicts Cardiovascular Outcomes in CKD, Especially in Advanced Stages · 2025 · DOI

  • Calcium-phosphate metabolism (parathyroid hormone [PTH], vitamin D [25(OH)D]) may influence circadian BP rhythms, but their independent roles remain unclear.

    Parathyroid hormone and vitamin D modulate nocturnal blood pressure dipping: a retrospective cohort study in primary hypertension · 2025 · DOI

  • Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.

    The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China · 2024 · DOI

  • There is a need for a comprehensive evaluation of the relative efficacy of sacubitril/valsartan vs. active antihypertensive comparators in reversing LVH. Prior studies have reported inconsistent findings and have methodological limitations.

    Reversal of left ventricular hypertrophy with sacubitril/valsartan vs. standard antihypertensive agents in hypertension: a systematic review and network meta-analysis · 2026 · DOI

  • There is a need to evaluate drug utilization patterns of antihypertensive medications in a tertiary care hospital. There is a need to assess whether pharmacotherapy aligns with current evidence-based guidelines.

    Drug utilisation study of anti-hypertensive drugs in a tertiary care hospital · 2026 · DOI

  • The fear of adverse effects remained a significant barrier to optimal beta-blocker utilization among nurses. Healthcare professionals' lack of knowledge and attitudes towards beta-blocker use. The need for clinical education and practice improvement initiatives.

    Optimizing beta-blocker therapy in cardiovascular care: a national cross-sectional assessment of physicians’ and nurses’ knowledge, attitudes, and practices in Saudi Arabia · 2026 · DOI

  • The lack of studies assessing the knowledge, attitudes, and practices of physicians and nurses regarding beta-blocker use in cardiovascular patients.

    Optimizing beta-blocker therapy in cardiovascular care: a national cross-sectional assessment of physicians’ and nurses’ knowledge, attitudes, and practices in Saudi Arabia · 2026 · DOI

  • While Left Ventricular Hypertrophy is a clearly a strong and independent predictor for coronary disease, it remains to be shown that a lower risk for coronary morbid events exists in patients whose Left Ventricular Hypertrophy has undergone regression over and above that attribute to blood pressure reduction.

    REVIEW ON HYPERTENSION AND ANTIHYPERTENSIVE DRUGS · 2026 · DOI

  • Substantial heterogeneity was observed in the analysis. The certainty of the main comparisons was low-to-very-low. The study was limited to published RCTs and may not be generalizable to other populations.

    Reversal of left ventricular hypertrophy with sacubitril/valsartan vs. standard antihypertensive agents in hypertension: a systematic review and network meta-analysis · 2026 · DOI

  • Limited external validation in diverse populations, - Inadequate calibration assessment and reporting, - Lack of clinical-impact studies, - Evidence remains especially limited in Latin America, Africa, and several parts…

    Prognostic Models for Incident Hypertension: Time to Move from Development to Implementation—An Umbrella Review · 2026 · DOI

  • Further research is needed to refine the inclusion of non-traditional risk factors in risk charts, - Further research is needed to evaluate the impact of non-traditional risk factors on public health outcomes, - Research is needed to determine the pathophysiological mechanisms of autoimmune diseases in increasing CVD…

    Non-Traditional Cardiovascular Risk Factors: Tailored Assessment and Clinical Implications · 2025 · DOI

  • Further research should investigate the mechanisms underlying sex differences in vascular parameters, - Longitudinal studies should be conducted to examine the long-term implications of sex differences in vascular health, - Research should focus on developing sex-specific reference values and personalized treatment…

    Sex-Specific Patterns in Blood Pressure and Vascular Parameters: The MUJER-EVA Project · 2025 · DOI

  • Further studies could investigate the long-term effects of the web-based HBPM program, - Research could explore the program's effectiveness in different populations, - Studies could examine the cost-effectiveness…

    Efficacy of a Web-Based Home Blood Pressure Monitoring Program in Improving Predialysis Blood Pressure Control Among Patients Undergoing Hemodialysis: Randomized Controlled Trial · 2024 · DOI

Most-cited papers in Blood Pressure and Hypertension Studies

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Open questions raised by papers listed on this page include: (1) The lack of clinical trials in paediatric patients and the scarcity of appropriate pharmaceutical formulations (“Combination therapy and formulation challenges in paediatric hypertension: an…”, 2026); (2) Whether South Africa's 1994 political transition interrupted this intergenerational transmission remains unknown (“Intergenerational hypertension transmission before and after South Africa's…”, 2026); (3) The association between the nondipper heart rate (NDHR) and the risk of LVH remains unclear (“Synergistic impact of nondipper heart rate and blood pressure on left…”, 2026); (4) The Chinese visceral adiposity index (CVAI) has been shown to be a practical indicator of visceral adiposity, but its association with prevalent hypertension in older adults remains unclear (“Association between Chinese visceral adiposity index and prevalent hypertension…”, 2026); (5) Whether RC contributes to the transition from prehypertension to clinical hypertension remains unclear (“Remnant cholesterol predicts progression from prehypertension to incident…”, 2026). 781 gap statements have been mined from Blood Pressure and Hypertension Studies papers in our 7.9M-paper local library, which holds 4,639 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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