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Open research questions in Blood transfusion and management

48 unresolved questions extracted from the limitations and future-work sections of 280 Blood transfusion and management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The risk of bacterial contamination during blood donation, processing, or storage cannot be completely eliminated. There is a need for heightened awareness among healthcare professionals regarding signs of transfusion-associated sepsis.

    Consideration in Platelet Transfusion-Transmitted Klebsiella pneumoniae Sepsis: A Case Report · 2026 · DOI

  • Accurate assessment of total and hidden blood loss remains methodologically challenging. Hemoglobin drop cannot be used as a reliable quantitative measure of hidden blood loss in individual patients. Reliance on hemoglobin drop alone may lead to under-or overestimation of true blood loss.

    Hidden blood loss estimation using perioperative hemoglobin drop: agreement with the Sehat formula · 2026 · DOI

  • The current study aims to address the gap in understanding the relationship between blood extraction volume and changes in hemoglobin and hematocrit levels. Prior work has documented significant blood loss due to diagnostic extractions, but the current study provides new insights into this relationship.

    Asociación entre la cantidad de sangre extraída con la variación de valores de hemoglobina y hematocrito en pacientes de UCI. Un estudio de cohorte prospectiva. · 2026 · DOI

  • The effectiveness of a hospital policy of tranexamic acid administration in reducing red-cell transfusion in major noncardiac surgery is uncertain. There is a need for strategies to reduce the demand for transfusion due to the increasingly constrained supply of blood components.

    Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery · 2026 · DOI

  • The potential venous thromboembolic effect of tranexamic acid. The optimal dosage, timing, and route of tranexamic acid administration. The need to minimize perioperative blood loss and reduce the need for transfusions.

    Use of tranexamic acid in primary hip arthroplasty: a retrospective audit of blood loss and transfusion rates · 2026 · DOI

  • Clinically significant blood loss remains common during shoulder arthroplasty. Prior studies have reported varying postoperative transfusion rates following shoulder arthroplasty.

    Intravenous versus oral tranexamic acid in shoulder arthroplasty · 2026 · DOI

  • Further studies are needed to investigate the relationship between haematological parameters and bone marrow dysfunction in patients with ALL. Studies should be conducted to evaluate the potential use of mean platelet volume and reticulocyte count as complementary indicators of bone marrow dysfunction.

    Mean Platelet Volume and Its Association with Total White Blood Cell and Reticulocyte Counts among Patients with Acute Lymphoblastic Leukaemia: A Hospital-Based Case–Control Study · 2026 · DOI

  • There is a need to investigate the association between mean platelet volume and total white blood cell and reticulocyte counts in patients with ALL. There is a lack of studies that have evaluated the relationship between these haematological parameters in patients with ALL.

    Mean Platelet Volume and Its Association with Total White Blood Cell and Reticulocyte Counts among Patients with Acute Lymphoblastic Leukaemia: A Hospital-Based Case–Control Study · 2026 · DOI

  • The study had a low event rate and wide CIs. The study was limited by the sparse outcome data. The study was a retrospective cohort study and may be subject to biases.

    Posttransfusion Alloimmunization Following Corticosteroid Treatment · 2026 · DOI

  • There is a need to investigate the association between corticosteroid use and decreased alloimmunization. Prior studies have shown conflicting results and the current study aims to address this gap.

    Posttransfusion Alloimmunization Following Corticosteroid Treatment · 2026 · DOI

  • There is a need to describe the characteristics of initial hemoglobin levels among patients with acute gastrointestinal bleeding. Prior work has not fully addressed this research question.

    Karakteristik Kadar Hemoglobin Awal pada Pasien Perdarahan Saluran Cerna Akut · 2026 · DOI

  • The agreement between perioperative hemoglobin drop and Sehat-derived hidden blood loss has not been fully evaluated. The clinical interpretability of hemoglobin-based blood loss estimation is not well understood.

    Hidden blood loss estimation using perioperative hemoglobin drop: agreement with the Sehat formula · 2026 · DOI

  • Future studies should evaluate the relationship between hemoglobin levels and the need for transfusion or clinical outcomes. Future studies should assess the time of onset, volume of blood loss, and changes in body fluid.

    Karakteristik Kadar Hemoglobin Awal pada Pasien Perdarahan Saluran Cerna Akut · 2026 · DOI

  • The current model integrates multiple clinical factors but lacks systematic incorporation of blood donor parameters and additional laboratory markers that may enhance prediction accuracy for red blood cell transfusion efficacy in VLBW infants.

    Analysis of the Efficacy of Red Blood Cell Transfusion in Very Low Birth Weight Infants and Construction of a Prediction Model · 2026 · DOI

  • Unmeasured maternal factors such as gestational anemia were not documented in the retrospective design, potentially confounding the relationship between transfusion efficacy predictors and outcomes in VLBW infants. Prospective protocols should standardize collection of maternal hematologic parameters.

    Analysis of the Efficacy of Red Blood Cell Transfusion in Very Low Birth Weight Infants and Construction of a Prediction Model · 2026 · DOI

  • The anti-inflammatory mechanisms of tranexamic acid have been evidenced through reductions in IL-6 and C-reactive protein levels, but the relationship between inflammatory marker suppression and postoperative pain/swelling reduction in joint replacement surgery requires quantitative dose-response characterization to optimize therapeutic regimens.

    Tranexamic Acid in Total Knee and Hip Arthroplasty: Dosing Strategies and Routes of Administration – A Narrative Review · 2026 · DOI

  • While tranexamic acid efficacy has been demonstrated across intravenous, oral, and topical routes in total knee and hip arthroplasty, the optimal route selection for specific high-risk patient subpopulations (diabetics, obese patients) requires additional comparative effectiveness research to guide clinical decision-making.

    Tranexamic Acid in Total Knee and Hip Arthroplasty: Dosing Strategies and Routes of Administration – A Narrative Review · 2026 · DOI

  • However, evaluation of hemostasis property of WB alone is insufficient to ensure that endogenous red blood cells (RBC) and platelets are maintaining other critical functional parameters that are measurable in vitro.

    Evaluation of stored whole blood cellular components treated with bactericidal peptides at a higher concentration than required to assess the peptide compatibility with product quality. · 2026 · DOI

  • The need for reliable risk stratification tools to support individualized perioperative blood management. The lack of a multivariable model for perioperative transfusion risk in elective primary total hip arthroplasty.

    A multivariable model for perioperative transfusion risk in elective primary THA · 2026 · DOI

  • Numerous modest-sized and heterogeneously designed trials highlighted the potential benefit of tranexamic acid in noncardiac surgery, but their individual and aggregate results were limited by the lack of generalizability when applied at a hospital BART and the ATACAS (Aspirin 18 17 7 6 level and the lack of systematically obtained long-term thrombotic outcomes.

    Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery · 2026 · DOI

  • The study had a limited sample size of 50 patients. The study only included orthopedic patients undergoing lower extremity surgery. The study did not compare the efficacy of different methods in different types of surgeries.

    Kombine Lomber Pleksus ve Siyatik Sinir Bloğu Yapılan Cerrahilerde Blok Kalitesinin Değerlendirilmesinde Perfüzyon İndeksi (PI), Kızılötesi Spektrometre (NIRS), ve Noninvazif Total Hemoglobin Monitörizasyonu (SpHb) Yöntemlerinin Karşılaştırılması · 2026 · DOI

  • Current practice often involves empirical selection of tourniquet pressures based on institutional routines or surgeon preference. The use of individualized tourniquet pressures is not common in current practice. There is a need for studies investigating the use of individualized tourniquet pressures in knee arthroscopy.

    Optimizing tourniquet pressures in knee arthroscopy: an international survey on current practice and a double-blind randomized trial · 2026 · DOI

  • There is a need to improve blood utilization in brain tumor surgery. The current blood ordering practices are inefficient, leading to unnecessary cross-matching and blood wastage.

    Transfusion Indexes and Machine Learning Prediction of Red Cell Transfusion in Brain Tumor Surgery · 2026 · DOI

  • There are significant discrepancies in reported bleeding phenotypes in prior work. A comprehensive characterization of the bleeding phenotype in Wiskott-Aldrich syndrome is needed. The resultant mortality burden among patients with WAS is not well understood.

    The spectrum of bleeding in Wiskott-Aldrich syndrome: a systematic review and meta-analysis of incidence and mortality · 2026 · DOI

  • Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data. long-term survival into adulthood, especially among those with the attenuated phenotype, multi-institutional prospective cohorts with extended follow-up are warranted.

    The spectrum of bleeding in Wiskott-Aldrich syndrome: a systematic review and meta-analysis of incidence and mortality · 2026 · DOI

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48 open questions have been extracted from the limitations and future-work passages of 280 Blood transfusion and management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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