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Open research questions in Blood transfusion and management

140 gap statements mined from Blood transfusion and management papers in our 4.5M-paper local library, which holds 706 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • There is a need to identify key determinants influencing RBC transfusion efficacy in VLBW infants. There is a need to guide red blood cell transfusion in VLBW infants and provide a basis for clinical individualized transfusion decision-making.

    Analysis of the Efficacy of Red Blood Cell Transfusion in Very Low Birth Weight Infants and Construction of a Prediction Model · 2026 · DOI

  • The current model integrates multiple clinical factors but lacks systematic incorporation of blood donor parameters and additional laboratory markers that may enhance prediction accuracy for red blood cell transfusion efficacy in VLBW infants.

    Analysis of the Efficacy of Red Blood Cell Transfusion in Very Low Birth Weight Infants and Construction of a Prediction Model · 2026 · DOI

  • There is a need to evaluate the efficacy of different TXA dosing strategies and administration routes. The impact of TXA on blood loss and clinical outcomes requires further assessment.

    Tranexamic Acid in Total Knee and Hip Arthroplasty: Dosing Strategies and Routes of Administration – A Narrative Review · 2026 · DOI

  • There is a need to evaluate the effects of bactericidal peptides on whole blood cellular components. There is a need to assess the peptide compatibility limits on product quality.

    Evaluation of stored whole blood cellular components treated with bactericidal peptides at a higher concentration than required to assess the peptide compatibility with product quality. · 2026 · DOI

  • Several limitations should be acknowledged. The retrospective design limits causal inference, and residual confounding cannot be excluded. Sehat-derived hidden blood loss itself represents an estimate rather than a direct measurement and may be influenced by perioperative fluid management and timing of laboratory sampling.

    Hidden blood loss estimation using perioperative hemoglobin drop: agreement with the Sehat formula · 2026 · DOI

  • The current study aims to address the gap in understanding the relationship between blood extraction volume and changes in hemoglobin and hematocrit levels. Prior work has documented significant blood loss due to diagnostic extractions, but the current study provides new insights into this relationship.

    Asociación entre la cantidad de sangre extraída con la variación de valores de hemoglobina y hematocrito en pacientes de UCI. Un estudio de cohorte prospectiva. · 2026 · DOI

  • Limited understanding of the frequency and characteristics of acute transfusion reactions at King Saud Medical City. Need for improved hemovigilance systems and clinician education to reduce the risk of acute transfusion reactions.

    Frequency of Acute Adverse Transfusion Reactions at King Saud Medical City, Riyadh, Saudi Arabia · 2026 · DOI

  • The need for reliable risk stratification tools to support individualized perioperative blood management. The lack of a multivariable model for perioperative transfusion risk in elective primary total hip arthroplasty.

    A multivariable model for perioperative transfusion risk in elective primary THA · 2026 · DOI

  • The study had a limited sample size of 50 patients. The study only included orthopedic patients undergoing lower extremity surgery. The study did not compare the efficacy of different methods in different types of surgeries.

    Kombine Lomber Pleksus ve Siyatik Sinir Bloğu Yapılan Cerrahilerde Blok Kalitesinin Değerlendirilmesinde Perfüzyon İndeksi (PI), Kızılötesi Spektrometre (NIRS), ve Noninvazif Total Hemoglobin Monitörizasyonu (SpHb) Yöntemlerinin Karşılaştırılması · 2026 · DOI

  • The need to minimize perioperative blood loss and reduce the need for transfusions.

    Use of tranexamic acid in primary hip arthroplasty: a retrospective audit of blood loss and transfusion rates · 2026 · DOI

  • Current practice often involves empirical selection of tourniquet pressures based on institutional routines or surgeon preference. The use of individualized tourniquet pressures is not common in current practice. There is a need for studies investigating the use of individualized tourniquet pressures in knee arthroscopy.

    Optimizing tourniquet pressures in knee arthroscopy: an international survey on current practice and a double-blind randomized trial · 2026 · DOI

  • There is a need to improve blood utilization in brain tumor surgery. The current blood ordering practices are inefficient, leading to unnecessary cross-matching and blood wastage.

    Transfusion Indexes and Machine Learning Prediction of Red Cell Transfusion in Brain Tumor Surgery · 2026 · DOI

  • Further studies are needed to investigate the relationship between haematological parameters and bone marrow dysfunction in patients with ALL. Studies should be conducted to evaluate the potential use of mean platelet volume and reticulocyte count as complementary indicators of bone marrow dysfunction.

    Mean Platelet Volume and Its Association with Total White Blood Cell and Reticulocyte Counts among Patients with Acute Lymphoblastic Leukaemia: A Hospital-Based Case–Control Study · 2026 · DOI

  • There is a need to investigate the association between mean platelet volume and total white blood cell and reticulocyte counts in patients with ALL. There is a lack of studies that have evaluated the relationship between these haematological parameters in patients with ALL.

    Mean Platelet Volume and Its Association with Total White Blood Cell and Reticulocyte Counts among Patients with Acute Lymphoblastic Leukaemia: A Hospital-Based Case–Control Study · 2026 · DOI

  • Excluded patients were not characterized demographically because the institutional statistician did not provide these data to the principal investigator. Additional studies are needed with larger cohorts, more events, and more granular characterization of immunosuppression to better define whether corticosteroid exposure influences alloantibody formation after transfusion.

    Posttransfusion Alloimmunization Following Corticosteroid Treatment · 2026 · DOI

  • There is a need to describe the characteristics of initial hemoglobin levels among patients with acute gastrointestinal bleeding. Prior work has not fully addressed this research question.

    Karakteristik Kadar Hemoglobin Awal pada Pasien Perdarahan Saluran Cerna Akut · 2026 · DOI

  • The role of Hemovac drainage after TKA remains uncertain in the tranexamic acid (TXA) era, particularly across patient subgroups.

    Body Mass Index Modifies the Effect of Hemovac Drainage on Blood Loss After Total Knee Arthroplasty · 2026 · DOI

  • Introduction Anemia and packed red blood cell (PRBC) transfusion are common in preterm infants, and feeding management during transfusion remains uncertain.

    Enteral feeding practices around neonatal packed red blood cell transfusion: A national survey of U.S. NICU providers · 2026 · DOI

  • Evidence in severe haemoptysis, ICU populations, and patients with major physiological instability remains uncertain, largely because treatment is often given to the sickest patients and outcomes are strongly influenced by respiratory failure, malignancy, infection, anticoagulation, and baseline cardiopulmonary reserve.

    Effectiveness and safety of antifibrinolytic agents in the management of pulmonary haemorrhage: A systematic review with narrative synthesis · 2026 · DOI

  • The placement of a PICC in this patient population requires careful planning and multidisciplinary review. The report highlights the need for further research on the safety and efficacy of PICC placement in patients with platelet counts below 10 × 10^9/L.

    Case Report: Urgent ultrasound-guided dual-lumen PICC placement after platelet transfusion in severe aplastic anemia with extreme thrombocytopenia · 2026 · DOI

  • Existing literature has predominantly focused on subgroups, resulting in limited comparability and a lack of integrated evidence across diagnostic categories. There is a need for a comprehensive overview of transfusion rates across the full diagnostic spectrum in oral and maxillofacial surgery.

    Transfusion rates in oral and maxillofacial surgery and their influencing factors in the context of patient blood management · 2026 · DOI

  • The anti-inflammatory mechanisms of tranexamic acid have been evidenced through reductions in IL-6 and C-reactive protein levels, but the relationship between inflammatory marker suppression and postoperative pain/swelling reduction in joint replacement surgery requires quantitative dose-response characterization to optimize therapeutic regimens.

    Tranexamic Acid in Total Knee and Hip Arthroplasty: Dosing Strategies and Routes of Administration – A Narrative Review · 2026 · DOI

  • Accurate assessment of total and hidden blood loss remains methodologically challenging. Hemoglobin drop cannot be used as a reliable quantitative measure of hidden blood loss in individual patients. Reliance on hemoglobin drop alone may lead to under-or overestimation of true blood loss.

    Hidden blood loss estimation using perioperative hemoglobin drop: agreement with the Sehat formula · 2026 · DOI

  • Numerous modest-sized and heterogeneously designed trials highlighted the potential benefit of tranexamic acid in noncardiac surgery, but their individual and aggregate results were limited by the lack of generalizability when applied at a hospital BART and the ATACAS…

    Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery · 2026 · DOI

  • Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data.

    The spectrum of bleeding in Wiskott-Aldrich syndrome: a systematic review and meta-analysis of incidence and mortality · 2026 · DOI

Most-cited papers in Blood transfusion and management

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Open questions raised by papers listed on this page include: (1) There is a need to identify key determinants influencing RBC transfusion efficacy in VLBW infants (“Analysis of the Efficacy of Red Blood Cell Transfusion in Very Low Birth Weight…”, 2026); (2) There is a need to evaluate the efficacy of different TXA dosing strategies and administration routes (“Tranexamic Acid in Total Knee and Hip Arthroplasty: Dosing Strategies and…”, 2026); (3) There is a need to evaluate the effects of bactericidal peptides on whole blood cellular components (“Evaluation of stored whole blood cellular components treated with bactericidal…”, 2026); (4) The lack of a multivariable model for perioperative transfusion risk in elective primary total hip arthroplasty (“A multivariable model for perioperative transfusion risk in elective primary THA”, 2026); (5) There is a need for studies investigating the use of individualized tourniquet pressures in knee arthroscopy (“Optimizing tourniquet pressures in knee arthroscopy: an international survey on…”, 2026). 140 gap statements have been mined from Blood transfusion and management papers in our 4.5M-paper local library, which holds 706 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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