Science AI Journal
Medicine · Research topic

Open research questions in Bone health and treatments

29 unresolved questions extracted from the limitations and future-work sections of 758 Bone health and treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Although BP-induced oral health problems are increasingly receiving attention, quantitative data validating the impact of such medication on alveolar bone conditions are scarce.

    Elevated alveolar bone mineral density in female patients undergoing bisphosphonate therapy: A pilot cross‐sectional study using intraoral radiographs · 2024 · DOI

  • Although the relationship between mandibular osteonecrosis and rheumatoid arthritis is not completely understood, we can conclude that the dental surgeon and the rheumatologist must always be in communication in order to treat mandibular osteonecrosis in the best possible way, as well as prevent its onset.

    Bisphosphonate-associated jaw osteonecrosis in the treatment of rheumatoid arthritis · 2024 · DOI

  • Denture trauma has been reported to be a risk factor for MRONJ, and few reports have discussed the prosthodontic considerations needed for patients with this condition.

    Medication-related osteonecrosis of the jaw: Prosthodontic considerations · 2021 · DOI

  • OBJECTIVES: While risk factors of bisphosphonate (BP) associated osteonecrosis of the jaw have been properly analyzed, studies focusing on risk factors associated with denosumab (DNO) are sparse.

    Risk factors associated with onset of medication-related osteonecrosis of the jaw in patients treated with denosumab · 2021 · DOI

  • The pathogenesis of denosumab-induced ONJ is not clearly defined, but it seems that the success rate in healing after drug discontinuation is higher than in bisphosphonates-induced ONJ.

    Osteonecrosis de los maxilares asociada a denosumab en una paciente con osteoporosis: un caso clínico · 2014 · DOI

  • Attention to be given to this bone pathologies in children and adolescents is warranted of its prognostic value for the rest of his life, to the peak bone mass of 20-21 years of age.

    Osteopenia in childhood and adolescence · 2014 · DOI

  • Studies on the relationship between bone tissue osteoporosis and the development of chronic generalized periodontitis are known in medicine; however, data on bone tissue changes in young patients with rapidly progressive periodontitis are insufficient.

    CHANGES IN THE BLOOD CHEMISTRY VALUES IN THE COURSE OF THE TREATMENT OF THE RAPIDLY PROGRESSIVE PERIODONTITIS · 2026 · DOI

  • Their patho-physiology still presents several poorly defined aspects, which have significantly delayed the availability of fully satisfactory drugs capable of achieving complete recovery.

    Clodronate and Neridronate: cornerstones of Osteometabolic therapy. · 2026 · DOI

  • The indication for radical surgery is not clearly defined, but this kind of treatment should only be instituted when conservative methods fail or when severe bone and soft-tissue necrosis prevails.

    Doble injerto microvascularizado de peroné para reconstrucción bilateral mandibular por osteorradionecrosis · 2010 · DOI

  • SUMMARY: Thorough reporting of every case of ONJ is important to help advance the understanding of this poorly understood condition.

    Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy: A Case Series · 2008 · DOI

Most-cited papers in Bone health and treatments

Most recent work

Find a gap in your own Bone health and treatments sub-topic

This page shows what the Bone health and treatments literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Substance Abuse Treatment and Outcomes
989 open questions
Artificial Intelligence in Healthcare and Education
607 open questions
Attention Deficit Hyperactivity Disorder
448 open questions
Physical Activity and Health
436 open questions
Smoking Behavior and Cessation
402 open questions
Innovations in Medical Education
364 open questions
Dementia and Cognitive Impairment Research
363 open questions
HIV/AIDS Research and Interventions
342 open questions
29 open questions have been extracted from the limitations and future-work passages of 758 Bone health and treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.