Science AI Journal
Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Bone Metabolism and Diseases

225 unresolved questions extracted from the limitations and future-work sections of 941 Bone Metabolism and Diseases papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study used a murine fracture and non-union model, - The study had a limited number of time points, - The study used a specific type of mouse, - The study did not investigate the cause of non-union formation in all cases

    Inflammasome expression patterns during bone regeneration: predictive biomarkers and potential therapeutic targets in non-union formation · 2026 · DOI

  • Investigating the cause of non-union formation in all cases, - Studying the role of inflammasomes in bone regeneration, - Examining the effects of different treatments on non-union formation, - Investigating the relationship between inflammatory response and bone healing

    Inflammasome expression patterns during bone regeneration: predictive biomarkers and potential therapeutic targets in non-union formation · 2026 · DOI

  • further studies are needed to confirm the findings, - research should focus on the effects of naringin on BMD and CTX-1, - studies should investigate the variability of effects across different osteoporosis models

    Preclinical effects of naringin on bone outcomes in animal models of osteoporosis: a systematic review and meta-analysis · 2026 · DOI

  • Quantitative evidence regarding the effects of naringin across different osteoporosis models and skeletal outcomes remains limited. The effects of naringin on bone outcomes in animal models of osteoporosis are not well understood. There is a need for a systematic review and meta-analysis to evaluate the preclinical effects of naringin on bone outcomes in animal models of osteoporosis.

    Preclinical effects of naringin on bone outcomes in animal models of osteoporosis: a systematic review and meta-analysis · 2026 · DOI

  • Assessing these hypotheses in clinical practice to develop innovative approaches for the screening, diagnosis, monitoring and treatment of osteoporosis, - Considering how age-related changes in platelet biology contribute to disease pathophysiology

    The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis · 2025 · DOI

  • The gap in current therapeutic strategies for osteoporosis, including adverse effects and suboptimal patient adherence. The limited understanding of the mechanisms of natural bioactive products in bone metabolism and regeneration. The need for further research to substantiate the efficacy and safety of these products in human populations.

    Natural bioactive products in the regulation of bone metabolism and regeneration · 2025 · DOI

  • Abstract Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored.

    The marine drug plitidepsin alleviates osteoporosis in estrogen-deficient mice by suppressing ROS-mediated NRF2/HO-1 signaling and osteoclast formation · 2026 · DOI

  • Increased pre-osteoblast cell density within bone resorption areas is a key factor in promoting osteoblast differentiation; however, the molecular mechanisms underlying this process remain poorly understood.

    Pannexin 3-mediated adenosine triphosphate release from pre-osteoblasts promotes osteoblast differentiation through P2X4 receptor activation · 2026 · DOI

  • However, the molecular mechanisms controlling this balance across skeletal homeostasis and disease remain unclear.

    Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis · 2026 · DOI

  • These findings highlight the need for further research on molecular targets in diabetic bone repair.

    Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del‐1, IL‐17, RANKL, and OPG Expression in a Rat Model · 2026 · DOI

  • Background Type 2 diabetes (T2D) is known to impair bone healing, yet the molecular mechanisms underlying this process in alveolar sockets remain insufficiently understood.

    Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del‐1, IL‐17, RANKL, and OPG Expression in a Rat Model · 2026 · DOI

  • However, whether these microstructural alterations arise from a specific cell death program remains unclear.

    Osteocyte necroptosis drives cortical bone resorption via osteocytic osteolysis in glucocorticoid-induced osteoporosis · 2026 · DOI

  • However, the precise chemical constituents of CG and its potential therapeutic targets for UC remain inadequately characterized.

    Amomum tsaoko extract from Nujiang alleviates DSS-induced colitis through inhibiting necroptosis · 2026 · DOI

  • INTRODUCTION: B-cell lymphoma 6 (Bcl6) inhibits osteoclast differentiation in vitro; however, its role in orthodontic tooth movement (OTM) remains unclear.

    Roles of B-cell lymphoma 6 in orthodontic tooth movement of rat molars · 2025 · DOI

  • Further mechanistic investigations and rigorously designed clinical trials are warranted to substantiate their efficacy and safety in human populations.

    Natural bioactive products in the regulation of bone metabolism and regeneration · 2025 · DOI

  • However, the underlying molecular mechanisms and specific targets of PPIs-induced bone loss remain poorly understood.

    Exploring the mechanisms and targets of proton pump inhibitors-induced osteoporosis through network toxicology, molecular docking, and molecular dynamics simulations · 2025 · DOI

  • Conventional treatments, although effective, are limited by adverse effects and low long-term adherence.

    Polyphenols and Bone Health: A Comprehensive Review of Their Role in Osteoporosis Prevention and Treatment · 2025 · DOI

  • Pre-osteoblasts (Tagln-expressing osteocyte precursors) support B cell maturation, but their specific roles remain unclear.

    Role of Tagln-Expressing Cells in Hypoxia-Mediated Disruption of B Cell Development 4523 · 2025 · DOI

  • Abstract Description Bone marrow (BM) microenvironments support B lymphocyte development, but the impact of hypoxia pathway dysregulation in specific niche components remains unclear.

    Role of Tagln-Expressing Cells in Hypoxia-Mediated Disruption of B Cell Development 4523 · 2025 · DOI

  • Denosumab (Deno), a widely utilized therapeutic agent for postmenopausal osteoporosis, has not been previously investigated for its effects on gut health.

    Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy · 2025 · DOI

  • Sinensetin (SIN), one of the main ingredients in citrus fruits, provides a variety of pharmacological properties, like antioxidant, but its effects on osteoporosis remains unknown.

    Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization · 2025 · DOI

  • Dysregulated expression of integrin α2 (ITGA2) promotes malignant progression in multiple cancers, yet its role in osteosarcoma and correlation with bone destruction remain poorly understood.

    The integrin α2-osteoclast axis: a key driver of bone destruction and therapeutic target in osteosarcoma · 2025 · DOI

  • Abstract The effect of immunoinflammation on bone repair during the recovery process of bone defects needs to be further explored.

    Magnesium Ions Promote the Induction of Immunosuppressive Bone Microenvironment and Bone Repair through HIF‐1α‐TGF‐β Axis in Dendritic Cells · 2024 · DOI

  • The target cells and specific molecular mechanisms of TCM in preventing and treating osteoporosis have not been fully elucidated.

    Osteoporosis treatment: current drugs and future developments · 2024 · DOI

  • Background The relationship between type 2 diabetes mellitus (T2DM) and osteoporosis (OP) has been widely recognized in recent years, but the mechanism of interaction remains unknown.

    Integrated analysis of genes shared between type 2 diabetes mellitus and osteoporosis · 2024 · DOI

Most-cited papers in Bone Metabolism and Diseases

Most recent work

Find a gap in your own Bone Metabolism and Diseases sub-topic

This page shows what the Bone Metabolism and Diseases literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Biochemistry, Genetics and Molecular Biology

Gut microbiota and health
1,024 open questions
Single-cell and spatial transcriptomics
602 open questions
Genetic Associations and Epidemiology
393 open questions
Antibiotic Resistance in Bacteria
360 open questions
Inflammatory Bowel Disease
353 open questions
Extracellular vesicles in disease
305 open questions
Mitochondrial Function and Pathology
296 open questions
Human-Animal Interaction Studies
294 open questions
225 open questions have been extracted from the limitations and future-work passages of 941 Bone Metabolism and Diseases papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.