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Open research questions in Cancer and Skin Lesions

57 unresolved questions extracted from the limitations and future-work sections of 528 Cancer and Skin Lesions papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study is retrospective and single-institution. The sample size is limited to 55 patients. The study does not include a control group.

    Histopathological changes in primary extramammary Paget disease with emphasis on syringomatous structures and syringocystadenocarcinoma papilliferum <i>in situ</i> ‑like changes · 2026 · DOI

  • The diagnostic challenge arises from an overlap between benign and malignant entities, particularly melanocytic and non-melanocytic conditions such as subcorneal hematoma. There is a need for a noninvasive tool to aid in differentiation between benign and malignant acral pigmented lesions.

    Acral Subcorneal Hematoma Mimicking Melanoma: Dermoscopic Features and Exploratory Digital Color Analysis · 2026 · DOI

  • Diagnostic challenges due to similarity with basal cell carcinoma. Therapeutic challenges due to limited literature on adjuvant radiotherapy. The need for accurate histopathologic differentiation.

    Low-Grade Trichoblastic Carcinoma of the Scalp: A Rare Case Managed With Adjuvant Radiotherapy · 2026 · DOI

  • The study is a case report, which may not be representative of all EMPD cases. The sample size is limited to one patient.

    Photodynamic technology for delineating surgical margins in recurrent extramammary Paget’s disease: a case report · 2026 · DOI

  • Further studies are needed to evaluate the efficacy and safety of photodynamic diagnosis in a larger cohort of EMPD patients. The comparison of photodynamic technology with conventional MMS in terms of recurrence rate and patient comfort.

    Photodynamic technology for delineating surgical margins in recurrent extramammary Paget’s disease: a case report · 2026 · DOI

  • Diagnosis is challenging due to its rarity and clinical resemblance to common benign perianal lesions. There is a lack of research on the management of Hidradenoma papilliferum. Malignant transformation is a potential risk.

    Integrated management of Medoja granthi (Hidradenoma papilliferum): A rare case report · 2026 · DOI

  • The clinical presentation of hidrocystoma is often nonspecific, making it challenging to diagnose. The lack of established ultrasound diagnostic criteria for cutaneous hidrocystoma makes it difficult to accurately diagnose and characterize the lesion. The variable sonographic features of hidrocystoma can lead to misdiagnosis as other superficial lesions.

    High-frequency ultrasound features of cutaneous hidrocystoma: a case series with imaging-pathology correlation · 2026 · DOI

  • Misdiagnosis of angiomyofibroblastoma. Limited understanding of the tumor's characteristics. Difficulty in distinguishing the tumor from other vulvar masses.

    Vulvar angiomyofibroblastoma misdiagnosed as subcutaneous lipoma: a case report and literature review · 2026 · DOI

  • There is a need for more research on the pathogenesis and management of afatinib-induced acneiform eruption. There is a need for more studies on the usefulness of dermoscopy and microscopy for diagnosis.

    Afatinib-Induced Acneiform Eruption in EGFR Exon 21 L858R-Mutant Stage IVA Lung Adenosquamous Carcinoma: Dermoscopy-Supported Diagnosis and Complete Resolution Fifteen Days After Drug Withdrawal · 2026 · DOI

  • There is a need for correct diagnosis and management of Acquired Vulvar Lymphangioma. The lesion can be confused with verrucous carcinoma.

    Acquired vulvar lymphangioma circumscriptum (AVLC): A rare clinical entity mimicking verrucous carcinoma · 2026 · DOI

  • Aims The nosology of primary cutaneous apocrine carcinoma remains controversial, as the term has often been used as a heterogeneous diagnostic category.

    Nosological reappraisal of primary cutaneous apocrine carcinoma based on a clinicopathological and genetic analysis of 30 cases · 2026 · DOI

  • Minor histopathological findings in PEMPD, including syringomatous structures and syringocystadenocarcinoma papilliferum (SCACP) in situ‑like changes, have rarely been reported.

    Histopathological changes in primary extramammary Paget disease with emphasis on syringomatous structures and syringocystadenocarcinoma papilliferum <i>in situ</i> ‑like changes · 2026 · DOI

  • The paper identifies a gap in the diagnosis of Paget's disease, where conventional imaging may not detect the underlying malignancy. There is a need for increased awareness and clinical suspicion of Paget's disease in patients with persistent unilateral nipple-areolar dermatitis.

    Paget’s disease of the nipple with occult ductal carcinoma <i>in situ</i> despite negative conventional imaging: A case report · 2026 · DOI

  • There is a lack of research on the management of Hidradenoma papilliferum using an integrated approach. There is a need for more studies on the effectiveness of histopathological examination in diagnosis.

    Integrated management of Medoja granthi (Hidradenoma papilliferum): A rare case report · 2026 · DOI

  • There is a lack of awareness about pilomatricoma as a differential diagnosis for subcutaneous lateral neck masses. Pilomatricoma is a rare and benign skin tumor that can occur in the submandibular region.

    The great mimicker: a case of neck pilomatricoma masked as submandibular gland · 2026 · DOI

  • There is a need for more effective and non-invasive treatment options for EMPD. The diagnosis of EMPD can be challenging due to its clinical features mimicking common inflammatory skin disorders.

    EXTRAMAMMARY PAGET'S DISEASE WITH METHOTREXATE THERAPY: A CASE REPORT · 2026 · DOI

  • Onkozytome des Augenlids are rare and difficult to diagnose. There is a need for more studies on the clinical and histological features of the tumors.

    Onkozytom des Augenlids: Fallserie mit histopathologischer Korrelation · 2026 · DOI

  • There is a lack of reports describing destructive necrotic lesions of the extremities accompanied by malignant transformation in RTS patients. The relationship between chronic tissue injury, persistent inflammation, and recurrent infection and malignant transformation in RTS skin is not well understood.

    Rapidly progressive acral necrosis and secondary cutaneous squamous cell carcinoma in a patient with Rothmund–Thomson syndrome · 2026 · DOI

  • Future research should focus on the development of more accurate and reliable methods for intraoperative cytology. The study of molecular analyses and their application to the diagnosis and treatment of pediatric anaplastic ependymoma is necessary.

    Pediatric anaplastic ependymoma — intraoperative cytology and histopathological grading roles in the morpho-molecular era · 2026 · DOI

  • The paper identifies a gap in the current understanding of the role of intraoperative cytology in the diagnosis of pediatric anaplastic ependymoma. There is a need for integrated morpho-molecular diagnosis of CNS tumors.

    Pediatric anaplastic ependymoma — intraoperative cytology and histopathological grading roles in the morpho-molecular era · 2026 · DOI

  • The precise incidence of keratoacanthoma remains uncertain due to frequent misdiagnosis as cutaneous squamous cell carcinoma. There is a need to identify features that can aid in distinguishing benign keratoacanthoma from keratoacanthoma with malignant transformation.

    Keratoacanthoma Revisited: Clinicopathological Features and Malignant Transformation in 115 Patients · 2026 · DOI

  • in Study Limitations This study has several limitations. Therefore, the independent prognostic significance of these variables in malignant transformation should be validated larger prospective studies. Third, the assessment of recurrence may have been limited by the loss of 20 patients to follow-up and the relatively short mean follow-up duration of 31 months, which may have precluded a comprehensive evaluation of long- term recurrence.

    Keratoacanthoma Revisited: Clinicopathological Features and Malignant Transformation in 115 Patients · 2026 · DOI

  • The study has a small sample size, with only 11 patients included. The study is limited by the absence of established ultrasound diagnostic criteria for cutaneous hidrocystoma. The study does not provide a formal diagnostic-performance analysis.

    High-frequency ultrasound features of cutaneous hidrocystoma: a case series with imaging-pathology correlation · 2026 · DOI

  • The need for a reliable method to differentiate between benign and malignant cutaneous horns. The lack of awareness of the dermoscopic changes that distinguish between benign and malignant lesions.

    Benign or malignant cutaneous horn: Dermoscopy to rescue · 2026 · DOI

  • The current literature does not show a causal association between splenosis and nephrolithiasis. There is a need to investigate the relationship between splenosis and nephrolithiasis.

    Splenosis Unmasked: Incidentally Rediscovered in a Patient With Nephrolithiasis and Remote Splenectomy · 2026 · DOI

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57 open questions have been extracted from the limitations and future-work passages of 528 Cancer and Skin Lesions papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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