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Open research questions in Cardiovascular Effects of Exercise

101 unresolved questions extracted from the limitations and future-work sections of 418 Cardiovascular Effects of Exercise papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Altered healthcare-seeking, hospital utilization, and match-day behavioral changes re- main plausible explanations, but the absence of a consistent post-match rebound indicates that the underlying mechanism remains uncertain.

    Watching the Game, Skipping the Hospital: World Cup Matches and Cardiovascular Hospitalizations · 2026 · DOI

  • We therefore could not determine whether match days affected symptom onset, emergency presentation, admission decisions, or some combination of these processes. We also could not assess out- of-hospital deaths or population-level mortality.

    Watching the Game, Skipping the Hospital: World Cup Matches and Cardiovascular Hospitalizations · 2026 · DOI

  • Purpose Exercise-induced cardiac adaptation in female athletes with extreme anthropometry remains poorly defined.

    Exploring morpho-functional and cardiometabolic parameters in elite female athletes with extreme anthropometry · 2026 · DOI

  • Despite increasing evidence supporting its benefits, many young patients remain insufficiently active because of concerns regarding exercise related risks, limited expertise.

    Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC) · 2026 · DOI

  • BACKGROUND: Young athletes and adolescents with high cardiorespiratory fitness appear to have a higher risk of atrial fibrillation (AF), but the extent to which this reflects causal effects or shared genetic, behavioral, and environmental factors remains uncertain.

    Adolescent Cardiorespiratory Fitness and the Trade-Off Between Atrial Fibrillation Risk and Cardiovascular Benefits: A Nationwide Sibling-Controlled Cohort Study · 2026 · DOI

  • In particular, few studies have integrated histopathology with genomic, transcriptional, and protein-level analyses in non-human primate cardiomyopathy.

    Integrative molecular pathology of sudden cardiac death associated with ARVC-like cardiomyopathy in a Western Lowland Gorilla · 2026 · DOI

  • Abstract Background Cardiovascular disease is a major cause of morbidity and mortality in captive great apes, however, the molecular basis of sudden cardiac death (SCD) in gorillas remains poorly characterized.

    Integrative molecular pathology of sudden cardiac death associated with ARVC-like cardiomyopathy in a Western Lowland Gorilla · 2026 · DOI

  • The molecular path from the variant of a gene to the clinical disease remains unclear.

    Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy · 2026 · DOI

  • OBJECTIVES: The cardiac morphology of elite athletes is related to sports disciplines and race; however, no studies have examined the effects of sports discipline on East Asian athletes.

    Differences in athlete’s left ventricular morphology by sex and sports discipline categories in elite Japanese athletes · 2025 · DOI

  • The significance of autopsy in SCD cases should be emphasised because autopsy imaging is still insufficiently reliable to identify certain cardiac diseases, and death certification by itself can be erroneous.

    Cardiovascular evaluation of athletes ahead of participation · 2025 · DOI

  • Background: Left atrial (LA) size and function are linked to exercise intolerance in heart failure, while associations between LA parameters and exercise performance remain unclear in athletes.

    Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel · 2025 · DOI

  • Background Limited data are available on the diagnostic performance of contemporary ECG interpretation criteria in master athletes (aged over 35 years).

    The diagnostic accuracy of contemporary ECG interpretation criteria in risk stratification of master athletes · 2025 · DOI

  • Despite artificial intelligence's proven effectiveness in managing chronic conditions, the limited research on its application in sports cardiology, particularly regarding wearables, creates a critical gap that needs to be addressed.

    Advancing Sports Cardiology: Integrating Artificial Intelligence with Wearable Devices for Cardiovascular Health Management · 2025 · DOI

  • BACKGROUND: Desmosomal gene variants (DGVs) have been associated with a diverse spectrum of phenotypic manifestations within arrhythmogenic cardiomyopathy, but data on genotype-specific outcomes are lacking.

    Genotype-Specific Outcomes of Desmosomal Cardiomyopathies · 2025 · DOI

  • Whereas mRNA-based therapies have shown efficacy in humans, their therapeutic potential for inherited cardiomyopathies remains unclear.

    Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2–Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy · 2025 · DOI

  • Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated.

    Bradycardia in Athletes: Prevalence, Mechanisms, and Risks · 2025 · DOI

  • Practically half of the genetic diagnoses remain inconclusive due to the identification of variants of uncertain significance.

    Appropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes · 2025 · DOI

  • 2 However, since the cause of death could not be determined in 25% of cases, this conclusion should be interpreted with caution.

    Mortality in female bodybuilding athletes · 2025 · DOI

  • Future research is needed to establish the relationship between clinically relevant CAD outcomes and coronary artery calcification in Masters athletes, the role of sex, as well as exploration of the mechanisms underpinning these unexpected CV adaptations.

    Focus on coronary atherosclerosis in athletes, angina with non-obstructive coronary arteries, mechanisms of acute vascular syndromes, and Marfan syndrome · 2025 · DOI

  • Neutrophil extracellular traps (NETs) trigger atherothrombosis during acute myocardial infarction (AMI), but the mechanisms of induction remain unclear.

    Focus on coronary atherosclerosis in athletes, angina with non-obstructive coronary arteries, mechanisms of acute vascular syndromes, and Marfan syndrome · 2025 · DOI

  • 19,20 Despite the potential association between herpes zoster infection and cardiovascular events, limited studies have investigated the relationship between live zoster vaccination and cardiovascular outcomes.

    The growing importance of non-traditional cardiovascular risk factors: global warning, infections, and extreme sports · 2025 · DOI

  • Residual confounding remains a concern, and the generalizability may be limited by the under-representation of Black individuals.

    The growing importance of non-traditional cardiovascular risk factors: global warning, infections, and extreme sports · 2025 · DOI

  • However, only few studies have explored the prognostic value of right atrial (RA) reservoir strain (RASr) in these patients, particularly when combined with RV FWS measures.

    Right chambers' strain in arrhythmogenic right ventricular cardiomyopathy · 2025 · DOI

  • The effects of exercise training on the atrial function in patients with ICM have been poorly investigated.

    Changes in left atrial function following two regimens of combined exercise training in patients with ischemic cardiomyopathy: a pilot study · 2024 · DOI

  • Therefore, this study, aimed to identify early changes in AH in soccer players by evaluating the echocardiographic findings of adolescent Asian female soccer players for whom existing data are scarce.

    Cardiac remodeling in elite young Asian female soccer players · 2024 · DOI

Most-cited papers in Cardiovascular Effects of Exercise

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101 open questions have been extracted from the limitations and future-work passages of 418 Cardiovascular Effects of Exercise papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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