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Open research questions in Cell Adhesion Molecules Research

98 gap statements mined from Cell Adhesion Molecules Research papers in our 4.5M-paper local library, which holds 342 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

What the literature leaves open

  • Disrupting DFC development and KV/ciliogenesis leads to organ LR patterning defects. The complex and diverse mechanisms for establishing organ LR patterning across different animal models. The difficulty in studying the early roles of Cdon in embryonic development due to limited understanding of its function.

    Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer’s vesicle morphogenesis · 2024 · DOI

  • Elucidate the possibility that the mutation of cdon may upregulate other genes to compensate for the loss of cdon function, - Investigate the detailed mechanism underlying the role of cdon in organ LR patterning

    Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer’s vesicle morphogenesis · 2024 · DOI

  • The advanced state of stage 4 colon cancer and limited therapeutic options. The complexity of the tumor microenvironment. The need to identify new biomarkers and therapeutic targets.

    Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis · 2024 · DOI

  • Investigating the functional roles of tetraspanins in CC progression, - Analyzing the expression of tetraspanins in other types of cancer, - Examining the potential of tetraspanins as diagnostic markers and therapeutic targets

    Spatial Transcriptomic Profiling of Tetraspanins in Stage 4 Colon Cancer from Primary Tumor and Liver Metastasis · 2024 · DOI

  • Although activation can be triggered by extracellular arginine-glycine-aspartic acid (RGD)-containing ligands as well as mechanical forces, how these biochemical and mechanical cues exactly govern the structural dynamics of α IIb β 3 remains unclear.

    All-atom simulations reveal distinct pathways for αIIbβ3 activation by biochemical vs. mechanical cues · 2026 · DOI

  • However, the development of bicyclic peptide ligands specifically targeting this integrin remains inadequately explored.

    Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence · 2026 · DOI

  • Cell adhesion tightly controls cell proliferation and homeostasis in stratified epithelia by mechanisms that remain unclear.

    Inactivation of Focal Adhesion Kinase FAK Rapidly Abrogates Keratinocyte Entry in Mitosis via Rho‐Associated Kinase, Resulting in Squamous Differentiation · 2026 · DOI

  • Tumor cell–derived secretome, comprising extracellular vesicles and soluble factors, has been implicated in cancer progression and metastatic dissemination; however, the mechanisms regulating its functional properties remain incompletely understood.

    The tetraspanin CD81 regulates the metastasis-promoting function of the osteosarcoma secretome · 2026 · DOI

  • CD151 drives tumor development and expression correlates with poor prognosis in solid cancers, but CD151 has not been studied in B cell malignancies.

    CD151 interacts with integrin beta 2 in B cell lymphomas · 2025 · DOI

  • However, activin receptor-like kinase 7 (ALK7), one of the TGFβ receptors, is under-investigated, and its roles in PDAC metastasis have been unclear.

    Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation · 2025 · DOI

  • Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood.

    Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation · 2025 · DOI

  • By synthesizing current knowledge, this paper aims to inspire further research into the therapeutic potential of targeting integrin pathways in stem cell-based tissue engineering.

    Integrin signaling pathways in mesenchymal stem cells · 2025 · DOI

  • However, the downstream effector of the SCD1-dependent mechanoresponsive pathway remains unclear.

    Matrix Stiffness Promotes Invasion and Metastasis of Hepatocellular Carcinoma via a New Mechanoresponsive SCD1 / HMMR Pathway · 2025 · DOI

  • While the involvement of GILT in the development of various tumors has been demonstrated, the mechanisms underlying its regulation in prostate cancer (PCa) are not fully understood.

    GILT stabilizes cofilin to promote the metastasis of prostate cancer · 2025 · DOI

  • Among TNF-a inhibitors-related cutaneous adverse reactions, paradoxical reactions are the most common, whereas sweet-like neutrophilic dermatosis or perforating dermatosis have been rarely reported.

    P66 Perforating dermatosis in a young female patient receiving adalimumab biosimilar CTP-17 for chronic plaque psoriasis · 2024 · DOI

  • However, its precise function and the underlying molecular mechanism in this disease remain unclear.

    DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway · 2024 · DOI

  • CD8+ T cell dysfunction impedes antitumor immunity in solid cancers, but the underlying mechanisms are diverse and poorly understood.

    Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment · 2024 · DOI

  • Further studies are needed to elucidate the role of the ECM in IBD. Research should focus on the development of therapeutic strategies to modulate the ECM and reduce inflammation. Investigations into the interactions between the ECM and immune cells can provide valuable insights into the pathogenesis of IBD.

    Inflammatory bowel disease and extracellular matrix: when victim becomes double agent · 2026 · DOI

  • The exact etiology of IBD remains unknown. The key mechanisms leading to the chronicity of intestinal inflammation are unknown. Few studies investigate the ECM's multiple roles in the sustenance and the exacerbation of the immune reaction.

    Inflammatory bowel disease and extracellular matrix: when victim becomes double agent · 2026 · DOI

  • There is a need to investigate prognostic and drug-responsive biomarkers to improve survival rates for patients with ovarian cancer. The challenges of chemotherapy resistance and resistance to targeted therapies continue to significantly impede the enhancement of prognostic outcomes for patients with OC.

    Overexpression of COL10A1 in extracellular matrix predicts poor outcome and promotes ovarian cancer progression · 2026 · DOI

  • The study used a limited number of replicates (n = 6) and was conducted at a single time point - Alternative mechanisms contributing to migration into collagen hydrogels were not explored

    Targeting the D93 cryptic collagen epitope alters integrin α2β1-dependent cellular migration and collagen remodeling in metastatic breast cancer · 2026 · DOI

  • Further studies are needed to explore the therapeutic potential of targeting the D93 cryptic collagen epitope - Studies should investigate the role of integrin α2β1 in cellular migration and collagen remodeling - Alternative mechanisms contributing to migration into collagen hydrogels should be explored

    Targeting the D93 cryptic collagen epitope alters integrin α2β1-dependent cellular migration and collagen remodeling in metastatic breast cancer · 2026 · DOI

  • The mechanisms by which neutrophils interact with endothelial cells during inflammation are not fully understood. The role of endothelial cortactin in neutrophil-endothelial interactions is not fully understood.

    Neutrophil serine proteases degrade endothelial cortactin and promote extravasation · 2026 · DOI

  • Current clinicopathological parameters remain insufficient to accurately predict which DCIS lesions will progress to invasive disease. There is a need to identify novel predictors for DCIS recurrence and progression.

    Collagen gene expression profiles predict recurrence and progression of DCIS to IDC · 2026 · DOI

  • The key drivers of phenotypic plasticity are not well understood - The role of IRF6 in EMT is not well understood

    Systems-level analysis identifies IRF6 as an inhibitor of epithelial-mesenchymal transition · 2026 · DOI

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98 gap statements have been mined from Cell Adhesion Molecules Research papers in our 4.5M-paper local library, which holds 342 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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