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Open research questions in Circular RNAs in diseases

129 unresolved questions extracted from the limitations and future-work sections of 300 Circular RNAs in diseases papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • translational applications of circRNAs in NSCLC, as either potential biomarkers or therapeutic targets

    Circular RNAs in NSCLC: Their Role in Tumorigenesis, Tumor Microenvironment Reshaping, and Response to Therapies · 2026 · DOI

  • The specific role and molecular mechanism of circHIPK3 in pediatric B-ALL are unknown. The interaction between circHIPK3 and STAT3 is not well understood. The potential of targeting the circHIPK3/STAT3 axis as a therapeutic strategy for B-ALL treatment has not been explored.

    CircHIPK3 promotes the progression of B-cell acute lymphoblastic leukemia in children by binding to STAT3 · 2026 · DOI

  • Investigate the dual functions of hub circRNAs in translational settings, - Examine the potential of hub circRNAs as biomarkers and therapeutic targets, - Conduct pan-cancer investigations

    Hub circRNAs in cancer: dual regulation of metastasis and immune evasion · 2026 · DOI

  • A lack of understanding of the mechanisms by which hub circRNAs coordinate metastasis and immune evasion. Limited knowledge of the role of hub circRNAs in cancer progression. A need for a comprehensive framework to organize available evidence.

    Hub circRNAs in cancer: dual regulation of metastasis and immune evasion · 2026 · DOI

  • current limitations clearly need to be overcome to translate circRNAs into the clinic

    Circular RNAs in NSCLC: Their Role in Tumorigenesis, Tumor Microenvironment Reshaping, and Response to Therapies · 2026 · DOI

  • While loss of TDP-43 induces aberrant splicing in linear transcripts, its impact on circular RNA (circRNA) biogenesis remains unexplored.

    Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases · 2026 · DOI

  • This research fills a gap in understanding how circRNAs regulate NDV-induced autophagy and provides a new perspective for understanding the interactions between host non-coding RNAs and viruses.

    CircRNA0857 acts as an miRNA sponge to promote Newcastle disease virus replication via modulating autophagy · 2026 · DOI

  • Background Circular RNAs (circRNAs) regulate cancer biology, but their relationships with parental genes remain unclear.

    Divergent roles of circMPP6 and its parental gene MPP6 in non-small cell lung cancer · 2026 · DOI

  • Background Few studies have investigated the detection of circular RNAs (circRNAs) in peripheral blood to discriminate stroke risk in atrial fibrillation (AF).

    Preliminary exploration of differentially expressed circular RNAs for discriminating atrial fibrillation-related stroke · 2026 · DOI

  • BACKGROUND AND AIMS: Cardiac remodelling following MI is intricately linked to macrophage polarization dynamics, yet the underlying mechanisms remain incompletely elucidated.

    Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction · 2026 · DOI

  • The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and drug resistance remain incompletely understood.

    A circRNA–mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer · 2025 · DOI

  • Circular RNAs (circRNAs) are key regulators in tissue homeostasis, yet their role in AF remains unclear.

    A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis · 2025 · DOI

  • Objective: Circular RNAs (circRNAs) are involved in various Cardiovascular diseases; however, the circRNA expression profiles and the circRNA-microRNA(miRNA)-messenger RNA (mRNA) regulatory network in rheumatic heart disease (RHD) remain poorly understood.

    Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker · 2025 · DOI

  • However, the mechanisms governing CD8+ T cell infiltration remain incompletely elucidated, particularly those involving circular RNAs (circRNAs).

    Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer · 2025 · DOI

  • However, the mechanisms by which these molecules influence the pathophysiological processes of asthma through target gene regulation remain unclear.

    circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b · 2025 · DOI

  • However, the comprehensive expression profile and competing endogenous RNA (ceRNA) regulatory network between mRNAs and ncRNAs involved in salivary gland development remain unclear.

    Transcriptome reveals the roles and potential mechanisms of CeRNA in the regulation of salivary gland development in the tick Rhipicephalus haemaphysaloides · 2025 · DOI

  • Circular RNAs (circRNAs), owing to their high stability and tissue-specific expression, have emerged as promising biomarkers, though their role in cervical carcinogenesis remains underexplored.

    The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis · 2025 · DOI

  • Despite advances in PD research, the molecular mechanisms underlying its pathogenesis remain incompletely understood.

    CircPRDM5-mediated regulation of miR-433-3p and HDAC6 in Parkinson's disease: a novel neuroprotective axis · 2025 · DOI

  • Fatigue is a common but poorly understood issue in type 2 diabetes (T2DM) that affects quality of life.

    The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete · 2025 · DOI

  • However, the effects of these changes on bone metabolism remain poorly understood.

    Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease · 2025 · DOI

  • BACKGROUND Extramural venous invasion (EMVI) is a critical prognostic factor in gastric cancer (GC); however, its detection and underlying molecular mechanisms remain underexplored.

    Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis · 2025 · DOI

  • Although more detailed studies are warranted, circRNAs are potentially related to ALS etiopathogenesis and could possibly serve as future biomarkers, therapeutic targets, or customized therapeutic tools to modulate the pathology.

    Circular RNA expression in ALS is progressively deregulated and tissue-dependent · 2025 · DOI

  • However, their function in avian skeletal muscle's response to insulin remains poorly understood.

    Identifying insulin-responsive circRNAs in chicken pectoralis · 2025 · DOI

  • However, the regulatory mechanisms of noncoding RNAs in Intramuscular fat deposition remain unclear.

    Molecular mechanism of nano-vitamin A-mediated regulation of intramuscular fat deposition involving noncoding RNAs in pigs · 2025 · DOI

  • Future research should focus on addressing these challenges to fully realize the therapeutic potential of circRNAs.

    CircRNAs: functions and emerging roles in cancer and immunotherapy · 2025 · DOI

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129 open questions have been extracted from the limitations and future-work passages of 300 Circular RNAs in diseases papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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