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Open research questions in Coffee research and impacts

151 gap statements mined from Coffee research and impacts papers in our 4.5M-paper local library, which holds 865 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The study had a limited number of Liberoid trees that met the required criteria during the observation period. The study used a purposive sampling method, which may not be representative of the entire population.

    Exploration and morphological variation of liberoid coffee (Coffea liberica) germplasm as a basis for genetic resource conservation · 2026 · DOI

  • Further studies could investigate the genetic diversity of Liberoid coffee. Further studies could explore the relationship between morphological traits and environmental factors. Further studies could develop breeding programs to improve the yield and quality of Liberoid coffee.

    Exploration and morphological variation of liberoid coffee (Coffea liberica) germplasm as a basis for genetic resource conservation · 2026 · DOI

  • The paper does not explicitly state the research gap. However, it can be inferred that the study aims to address the lack of understanding of the phytochemical composition and biological activity of green Coffea arabica seeds. The study also aims to explore the potential of solvent-guided fractionation in obtaining extracts with distinct biological effects.

    Solvent-Guided Fractionation of Green Coffea arabica Seeds Uncovers Divergent Antioxidant and Mitochondria-Targeted Activities · 2026 · DOI

  • There is a need for long-term studies on the effects of sustainable soil management on soil health in tropical coffee agroecosystems. Prior work has focused on short-term effects, and there is a lack of understanding of the long-term implications of conservation management strategies.

    Long-term soil health and microbiome responses to sustainable management under drought stress in tropical coffee agroecosystems · 2026 · DOI

  • The study does not mention any specific limitations. However, it can be inferred that the study is limited to a specific region (Vietnam's Central Highlands) and crop (Robusta coffee).

    Transpiration dynamics of Robusta coffee in response to irrigation regime, agroforestry system, and dry season severity · 2026 · DOI

  • There is a need to tailor irrigation practices to enhance the resilience of coffee systems. The study aims to address this gap by investigating the transpiration dynamics and productivity of Robusta coffee under different irrigation regimes and agroforestry systems.

    Transpiration dynamics of Robusta coffee in response to irrigation regime, agroforestry system, and dry season severity · 2026 · DOI

  • These findings suggest that GCGTE can inhibit hyperglycemia-induced fibrotic signaling and fibroblast activation, which to our knowledge, have not been reported by previous studies.

    Combined decaffeinated green coffee and green tea extracts prevents fibrosis and hypertrophy in high-glucose-treated fibroblasts · 2026 · DOI

  • These findings provide valuable preliminary molecular insights that should be further validated in larger, independent cohorts. Future studies using individual-level proteomic approaches and larger cohorts are warranted to further validate these findings and enable more comprehensive clinicoproteomic analyses. Future studies with more detailed exposure standardization are warranted.

    Comparative Serum Proteomic Analysis of Different Habitual Coffee Consumption Among Healthy and Obese with and Without Hypertension Groups · 2026 · DOI

  • The present systematic review included nine studies and the meta-analysis included a subset of six studies, reflecting the limited evidence base. Together, these findings highlight a critical gap in the literature, as current study designs lack the methodological rigor required to robustly evaluate menstrual cycle–dependent responses to caffeine in female athletes.

    Caffeine and physical performance in female intermittent sport athletes: a systematic review and meta-analysis considering menstrual cycle phase · 2026 · DOI

  • Further studies can be conducted to compare the caffeine levels in coffee from different regions. Further studies can be conducted to analyze the effects of caffeine on human health.

    Extraction and determination of caffeine content in ground coffee commercially available on Bosnian market · 2026 · DOI

  • The lack of comparable studies conducted in Bosnia and Herzegovina on caffeine levels in brewed coffee. The need to determine the level of caffeine in coffee brewed and consumed at home in Bosnia and Herzegovina.

    Extraction and determination of caffeine content in ground coffee commercially available on Bosnian market · 2026 · DOI

  • There is a need to investigate the effects of GCBE on lipid profile and oxidative stress. The study aims to fill the gap in the current literature on the health benefits of GCBE.

    Effects of green coffee bean extract supplementation on lipid profile and oxidative stress in female rabbits · 2026 · DOI

  • There is a lack of information on the optimal conditions for caffeine extraction from Ilex guayusa. There is a need to evaluate the physicochemical parameters and heavy metal levels of the freeze-dried extract.

    Extracto liofilizado de Ilex guayusa: potencial ingredientepara bebidas energizantes · 2026 · DOI

  • Climate change, - Market durability, - Lack of access to water and modern methods, - Inadequate infrastructure, - Limited access to technical knowledge, - Market uncertainties, - Price fluctuations, - Insufficient institutional support.

    SUSTAINABLE COFFEE FARMING IN KORAPUT: CHALLENGES AND OPPOURTUNITES FOR COFFEE FARMERS" A STUDY IN KORAPUT DISTRICT OF ODISHA · 2026 · DOI

  • There is uncertainty about the role of other dietary factors in arrhythmias. The association between cocoa and cardiac rhythm is not well-established.

    Cocoa and Cardiac Rhythm: an Arrhythmogenic Trigger in Dietetic Chocolate Abuse? · 2026 · DOI

  • The method does not represent a permanent solution to pesticide use. Future evaluations will include testing the rinse formulation across additional coffee species and assessing its effectiveness against a broader range of pesticides and contaminants.

    Innovative Coffee Detoxification Method Advancements · 2026 · DOI

  • However, there remains no consensus regarding caffeine’s effects on “higher” cognitive functions, such as problem solving and decision making.

    Effects of Acute Caffeine Ingestion on Morning Temperature, Mood, Reactive Agility and Cognitive Measures in Males: A Standardized Approach · 2026 · DOI

  • The indirect support provided by caffeine through non-specific arousal systems is insufficient to substantially optimize such complex cognitive processes, particularly in young, healthy populations in whom these functions are inherently at a high baseline level with limited capacity for improvement (45).

    Acute caffeine intervention and cognitive performance in populations aged 20 years and younger: a systematic review and meta-analysis · 2026 · DOI

  • Future research should investigate whether different caffeine doses, habitual caffeine exposure, caffeine metabolism-related genetic factors, and neuromuscular characteristics contribute to variability in individual responses to combined caffeine and PAPE interventions.

    Effects of acute caffeine ingestion on post-activation performance enhancement following individualized drop-jump conditioning in high-level male basketball players: a randomized, double-blind, placebo-controlled crossover trial · 2026 · DOI

  • Because the manuscript was reframed after screening revealed an unexpectedly sparse evidence base, the synthesis includes an explicitly interpretive and agenda-setting component and should not be read as a conventional systematic review or as a basis for pooled effect estimates.

    Beyond Ergogenic Effects: Limited Evidence on Caffeine-Related Problematic Use, Dependence, and Withdrawal in Athletic Populations—A Structured Narrative Review · 2026 · DOI

  • Soil degradation and erosion are major concerns in smallholder coffee systems. Limited access to training and resources can hinder the adoption of eco-friendly farming practices among smallholder farmers.

    Enhancing coffee productivity and disease resilience through ecological farming: evidence from smallholder systems in Kenya · 2026 · DOI

  • The study spanned approximately 20 months, which does not capture inter-annual climatic variability or long-term soil changes. The sample does not represent a statistically random draw from the cooperative population. The study had a small sample size, particularly in Ngaindethia, which limited the statistical significance of some findings.

    Enhancing coffee productivity and disease resilience through ecological farming: evidence from smallholder systems in Kenya · 2026 · DOI

  • Despite the recognition of Koraput coffee through the award of a Geographical Indication (GI) tag in 2019, coffee farmers in the region continue to face several challenges.

    SUSTAINABLE COFFEE FARMING IN KORAPUT: CHALLENGES AND OPPOURTUNITES FOR COFFEE FARMERS" A STUDY IN KORAPUT DISTRICT OF ODISHA · 2026 · DOI

  • Substantial heterogeneity in sport discipline, caffeine protocol, comparator, and outcome measures, - Limited to acute caffeine supplementation, - Did not establish a general advantage over isolated caffeine…

    Acute caffeine strategies for improving performance in combat sports: a structured narrative review · 2026 · DOI

  • Evaluate individual responses to caffeine during training before competition, - Investigate the effects of caffeine on strength, power, and muscular endurance in different combat sports, - Examine the effects of combined caffeine protocols…

    Acute caffeine strategies for improving performance in combat sports: a structured narrative review · 2026 · DOI

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Open questions raised by papers listed on this page include: (1) Further studies could investigate the genetic diversity of Liberoid coffee (“Exploration and morphological variation of liberoid coffee (Coffea liberica)…”, 2026); (2) It can be inferred that the study aims to address the lack of understanding of the phytochemical composition and biological activity of green Coffea arabica seeds (“Solvent-Guided Fractionation of Green Coffea arabica Seeds Uncovers Divergent…”, 2026); (3) There is a need for long-term studies on the effects of sustainable soil management on soil health in tropical coffee agroecosystems (“Long-term soil health and microbiome responses to sustainable management under…”, 2026); (4) There is a need to tailor irrigation practices to enhance the resilience of coffee systems (“Transpiration dynamics of Robusta coffee in response to irrigation regime,…”, 2026); (5) Future studies using individual-level proteomic approaches and larger cohorts are warranted to further validate these findings and enable more comprehensive clinicoproteomic analyses (“Comparative Serum Proteomic Analysis of Different Habitual Coffee Consumption…”, 2026). 151 gap statements have been mined from Coffee research and impacts papers in our 4.5M-paper local library, which holds 865 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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