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Open research questions in Dermatology and Skin Diseases

211 unresolved questions extracted from the limitations and future-work sections of 559 Dermatology and Skin Diseases papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Future prospective studies should combine repeated skin and nasal evaluation, paired biological sampling, careful control of shared determinants, and ethically appropriate mechanistic perturbation

    A systemic epithelial–immune–neural framework for pediatric atopic dermatitis–allergic rhinitis comorbidity · 2026 · DOI

  • The inconsistent adherence to minimum reporting standards and essential characterization requirements in terms of platelet enrichment, leukocyte content or activation status across studies. The regenerative and immunomodulatory properties of platelet-rich derivatives are highly dependent on multiple processing variables. Additional sources of variability associated with the use of platelet-rich derivatives contribute to substantial heterogeneity in the final product composition and local bioavailability.

    Platelet-rich therapies in cutaneous and mucocutaneous disorders characterized by inflammatory tissue responses: mechanistic insights and clinical evidence · 2026 · DOI

  • machine-learning multi-omic integration for PAD that incorporates targeted tryptophan-pathway metabolomics

    Tryptophan Metabolism in Pediatric Atopic Dermatitis: Shared Mechanisms, Age-Specific Biomarkers, and Emerging Therapies · 2026 · DOI

  • The lack of standardized, prospective studies directly contrasting age groups in tryptophan metabolism, - The limited direct pediatric evidence on tryptophan metabolism in atopic dermatitis, - The need for a dedicated pediatric tryptophan-pathway dataset

    Tryptophan Metabolism in Pediatric Atopic Dermatitis: Shared Mechanisms, Age-Specific Biomarkers, and Emerging Therapies · 2026 · DOI

  • Understanding the complex interplay between molecular mechanisms and skin disease is a challenge. Identifying new targets for therapeutic advancements is a challenge. The paper discusses the need for further research to clarify the contributions of hormonal mechanisms to the pathogenesis of hidradenitis suppurativa.

    Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology · 2024 · DOI

  • However, how staphylococcal strain variation affects disease aetiology and progression remains unclear.

    Isoleucine and asparagine influence the growth of staphylococcal strains in atopic dermatitis · 2026 · DOI

  • Natural killer (NK) cells play an important role in skin homoeostasis; however, their involvement in eAD remains unclear.

    Age-related changes of FCGR3A+ natural killer cells and their association with elderly atopic dermatitis · 2026 · DOI

  • Background Detailed clinical descriptions of paediatric atopic dermatitis from southern China are scarce; available Chinese data are largely modelled burden estimates or laboratory series of allergen sensitisation.

    Clinical profile, reported triggers, and comorbidity pattern in children and adolescents with atopic dermatitis: a cross-sectional study from Fujian, China · 2026 · DOI

  • Biologics targeting IL-13, including tralokinumab and lebrikizumab, have demonstrated efficacy in clinical trials; however, the therapeutic value of intra-class switching following primary treatment failure remains poorly defined, and existing real-world reports rarely distinguish primary from secondary failure.

    Case Report: Differential response to IL-13 inhibition: lebrikizumab following primary tralokinumab failure in atopic dermatitis · 2026 · DOI

  • Future research should focus on well-designed randomized controlled trials that account for potential sources of bias in order to provide evidence-based public health recommendations.

    Probiotics supplements for the prevention of atopic dermatitis in children: an umbrella review · 2025 · DOI

  • Notably, its prevalence and impact among elderly individuals remain poorly understood, highlighting the need for a deeper understanding of its global burden.

    The Global Burden of Atopic Dermatitis in Elderly Populations: Trends, Disparities, and Future Projections · 2025 · DOI

  • Alopecia areata (AA) is a common non-scarring hair loss condition whose specific pathogenesis is not yet fully understood.

    Case Report: Baricitinib improved alopecia areata in a pediatric patient with atopic dermatitis · 2025 · DOI

  • While most plakins are critical for maintaining epidermal integrity, the role of epiplakin (EPPK1) in inflammatory skin disorders has not been thoroughly investigated.

    Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures · 2025 · DOI

  • While previously not fully understood and limited in treatment options, AD is currently undergoing a therapeutic revolution.

    A translational approach to improve therapeutics in atopic dermatitis and beyond · 2025 · DOI

  • Abstract Description Skin-resident regulatory T (Treg) cells play a critical role in allergen-specific immunotherapy (SIT) for atopic dermatitis (AD), yet their function and origin remain incompletely understood.

    The Critical Function of a Peripheral-induced Skin-resident Treg cells in Allergen-Specific Immunotherapy for Atopic Dermatitis 9177 · 2025 · DOI

  • However, the neuronal circuit mechanisms underlying the comorbidity of anxiety in chronic itch remain elusive.

    A thalamic nucleus reuniens–lateral septum–lateral hypothalamus circuit for comorbid anxiety–like behaviors in chronic itch · 2024 · DOI

  • Although specific cell types have been proposed to underlie itch, the neural basis for itch remains unclear.

    Kappa opioids inhibit spinal output neurons to suppress itch · 2024 · DOI

  • To develop a more thorough understanding of skin pathology and to identify new targets for therapeutic advancements, molecular mechanisms of inflammation in the context of skin disease should be studied.

    Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology · 2024 · DOI

  • However, the interplay between skin bacteria and the lipids is not fully understood.

    Microbiome and lipidomic analysis reveal the interplay between skin bacteria and lipids in a cohort study · 2024 · DOI

  • Skin microecological imbalance is an important factor in the pathogenesis of AD, but the underlying mechanism of its interaction with humans remains unclear.

    Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis · 2024 · DOI

  • Perturbations in the intestinal bacteria and flora contributed to the development of AD, and the mouse model could serve as a valuable tool for further investigation of therapeutic approaches for managing ADS.

    The changes of intestinal flora and metabolites in atopic dermatitis mice · 2024 · DOI

  • Nevertheless, the risk of AEs with oral corticosteroids, especially among patients with atopic dermatitis (AD), has not been comprehensively investigated and lacks evidence on duration of treatment.

    Long-Term Use of Oral Corticosteroids and Safety Outcomes for Patients With Atopic Dermatitis · 2024 · DOI

  • The current management of atopic dermatitis has limitations, including the use of antibiotics and glucocorticoids. There is a need for novel therapeutic strategies for atopic dermatitis.

    Topical acacia gum reshapes staphylococcal dysbiosis and inflammation in atopic dermatitis · 2026 · DOI

  • The study uses only female BALB/c mice (6 weeks old) in the animal model, limiting generalizability to other mouse strains, ages, and sexes, which may respond differently to AG treatment.

    Topical acacia gum reshapes staphylococcal dysbiosis and inflammation in atopic dermatitis · 2026 · DOI

  • Further investigation of the signaling pathways involved in opioid-induced itch. Exploration of the therapeutic potential of targeting OPRM1 and MRGPRX1 heterodimers. Investigation of the role of other receptors and mechanisms in opioid-induced itch.

    OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism · 2026 · DOI

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211 open questions have been extracted from the limitations and future-work passages of 559 Dermatology and Skin Diseases papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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