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Open research questions in Diabetes Management and Research

267 unresolved questions extracted from the limitations and future-work sections of 1,392 Diabetes Management and Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The limited number of studies per subgroup, which requires cautious interpretation of findings. The uncertainty surrounding the effects of blood flow restriction training on metabolic outcomes. The need for larger trials with standardized protocols and extended follow-up to establish the safety and effectiveness of blood flow restriction training.

    Effectiveness and safety of blood flow restriction training for patients with type 2 diabetes mellitus: a systematic review with meta analysis · 2026 · DOI

  • The few studies per subgroup require cautious interpretation, - The limited evidence base precludes de nitive safety characterisation, - Larger trials with standardised protocols and extended follow-up are required

    Effectiveness and safety of blood flow restriction training for patients with type 2 diabetes mellitus: a systematic review with meta analysis · 2026 · DOI

  • The study identifies significant differences in scores of fear of hypoglycemia, diabetes distress, depressive symptoms, and diabetes self-management among adolescents with different demographic characteristics. The research highlights the need to develop strategies for promoting diabetes management in adolescents with T1DM, considering the mediating role of diabetes distress.

    The Mediator Testing of Association Between Fear of Hypoglycemia and Diabetes Self-Management in Chinese Adolescents with T1DM: Diabetes Distress or Depressive Symptoms? · 2026 · DOI

  • The study acknowledges the limitation of using retrospective data. The study notes that individual younger children may have required assistance reading items on the RCADS, which was not systematically recorded. The study highlights the need for further research to confirm the findings.

    Psychological and Glycemic Outcomes Associated with EMDR Therapy in Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Comparative Study · 2026 · DOI

  • further studies are needed to examine the long-term effects of EMDR therapy on children and adolescents with T1DM, - research should investigate the potential benefits of EMDR therapy on glycemic control, - studies should explore the use of EMDR therapy in other populations with chronic illnesses

    Psychological and Glycemic Outcomes Associated with EMDR Therapy in Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Comparative Study · 2026 · DOI

  • overcoming challenges in data privacy - addressing algorithmic bias - improving device interoperability - ensuring equity in AI-driven care -

    Future horizons in diabetes: integrating AI and personalized care · 2025 · DOI

  • Traditional markers like HbA1c are insufficient for capturing short-term glycemic fluctuations. Current management paradigms have limitations in terms of invasive procedures and medication dependence. There is a need for innovative approaches that address the growing global burden of diabetes and provide personalized care.

    Future horizons in diabetes: integrating AI and personalized care · 2025 · DOI

  • There is a lack of understanding of the global, regional, and national trends and burden of T2DM among youth. The study identifies a gap in the analysis of the incidence, prevalence, and Disability-Adjusted Life Years of T2DM among youth.

    Global, regional, and national trends and burden of diabetes mellitus type 2 among youth from 1990 to 2021: an analysis from the global burden of disease study 2021 · 2025 · DOI

  • The association between fear of hypoglycemia and diabetes self-management in adolescents with T1DM is not well understood. Chinese research on pediatric T1DM has traditionally prioritized acute complications and metabolic control, overshadowing psychological constructs like fear of hypoglycemia.

    The Mediator Testing of Association Between Fear of Hypoglycemia and Diabetes Self-Management in Chinese Adolescents with T1DM: Diabetes Distress or Depressive Symptoms? · 2026 · DOI

  • It remains unclear whether the combined conditions confer an excess risk of hypoglycaemia-related hospitalisation beyond the risks associated with either condition alone.

    Excess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study · 2026 · DOI

  • Its clinical value for dietary decision support remains to be tested prospectively.

    Few-shot personalized postprandial glucose prediction with model-agnostic neighbor fusion · 2026 · DOI

  • This study aimed to evaluate the prevalence and predictors of dyslipidemia in pediatric T1DM and determine whether screening before age 10 is warranted.

    Dyslipidemia in children with type 1 diabetes across age groups in Southern Iran: is it time to rethink guidelines? · 2026 · DOI

  • OBJECTIVE: Much remains unknown about how type 1 diabetes (T1D) affects one's identity and bodily experiences in emerging adults.

    Identity and bodily experiences in emerging adults with type 1 diabetes (T1D): a qualitative exploration · 2025 · DOI

  • Background: Although studies have looked at type 2 diabetes mellitus (T2DM) in adults, global studies on youth with T2DM are relatively scarce.

    Global, regional, and national trends and burden of diabetes mellitus type 2 among youth from 1990 to 2021: an analysis from the global burden of disease study 2021 · 2025 · DOI

  • Although the association with ischemic stroke is well established, the relationship with hemorrhagic stroke remains unclear.

    Risk of Ischemic and Hemorrhagic Stroke in Individuals With Type 1 and Type 2 Diabetes · 2025 · DOI

  • There are limited studies on the factors related to self-efficacy and health literacy associated with self-care behaviors among adolescents with T1DM in the Arab World, including Palestine.

    Self-Care behaviors and their association with self-efficacy and health literacy among adolescents with type 1 diabetes mellitus in palestine: a cross-sectional study · 2025 · DOI

  • CONCLUSION: There remains limited data on QoL outcomes or even a standardisation for measuring QoL in this cohort as seen by the various validated tools used across studies.

    Quality of life and physical activity in type 1 diabetes · 2025 · DOI

  • Given the limited data on the use of automated insulin delivery (AID) systems in type 2 diabetes, studies evaluating their safety and efficacy are important.

    Automated Insulin Delivery in Adults With Type 2 Diabetes · 2025 · DOI

  • However, the specifics of these adjustments and the reasoning for adopted strategies to manage cycle-induced changes on glucose control are not yet well understood and warrant further research.

    311-OR: Adapting Automated Insulin Delivery for Menstrual Cycle Variability in Type 1 Diabetes—Insights from a Combined Quantitative and Qualitative Study · 2025 · DOI

  • However, the extent to which screening has been implemented in clinical practice remains uncertain.

    1942-LB: Diabetes Distress Screening in Type 1 Diabetes—Are We Meeting Standards in Psychosocial Care? · 2025 · DOI

  • Future research should focus on improving the system's sensitivity under hypoglycemic conditions and exploring its broader applications, including its role in enhancing in-hospital glucose management, utilizing big data to facilitate online diagnostics and offline follow-up care, providing guidance for daily glucose stabilization, enabling personalized veterinary services, and offering subscription-based health reports for pet owners.

    Glucose monitoring intelligent tracking system for remote glycemic assessment in diabetic dogs: a novel approach · 2025 · DOI

  • However, few studies have examined these children's care pathways multidimensionally over time.

    Exploring patterns in pediatric type 1 diabetes care and the impact of socioeconomic status · 2025 · DOI

  • The ways in which adolescents respond to diabetes distress may serve as a risk or protective factor for these outcomes, but few studies have examined the coping strategies adolescents use to manage diabetes distress.

    Associations of Coping Strategies With Glycemic and Psychosocial Outcomes Among Adolescents With Type 1 Diabetes Experiencing Diabetes Distress · 2024 · DOI

  • To date, longitudinal person-centered studies are lacking that substantiate qualitative research capturing illness identity as a process.

    Stability and change of illness identity in Belgian youth with type 1 diabetes: a latent transition analysis · 2024 · DOI

  • Furthermore, TM's impact on quality of life and other clinical outcomes beyond glucose management remains underexplored.

    The impact of telemedicine on pediatric type 1 diabetes management: benefits, challenges, and future directions · 2024 · DOI

Most-cited papers in Diabetes Management and Research

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267 open questions have been extracted from the limitations and future-work passages of 1,392 Diabetes Management and Research papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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