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Open research questions in Diagnosis and Treatment of Venous Diseases

62 unresolved questions extracted from the limitations and future-work sections of 359 Diagnosis and Treatment of Venous Diseases papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The lack of surface landmarks makes it difficult to identify the ventral–dorsal boundary laparoscopically. Anatomical resection of the ventral or dorsal part is technically demanding due to the lack of a reliable method to identify the ventral–dorsal boundary.

    ICG-Enhanced Visualization of Venous Congestion for Laparoscopic Anatomical Liver Resection of Segment 8-Ventral · 2026 · DOI

  • Variability in patient positioning during duplex ultrasonography. Limited standardization in duplex ultrasonography protocols. Difficulty in diagnosing and treating varicose veins due to variability in reflux detection and saphenous vein diameter.

    EFFECT OF PATIENT POSITION ON HEMODYNAMIC AND ANATOMICAL ASSESSMENT OF LOWER-LIMB VARICOSE VEINS USING DUPLEX ULTRASONOGRAPHY · 2026 · DOI

  • Chronic leg ulcers are prevalent and persistent forms of lower extremity ulceration. The current standard of care (SOC) for VLUs has limitations in terms of healing outcomes. There is a need for adjunctive therapies, such as COMS, to improve healing outcomes.

    Adjunctive optical and magnetic stimulation for venous and mixed etiology leg ulcers: protocol for the NAZARÉ multicenter randomized controlled trial · 2026 · DOI

  • Significant variability in the reported measures of venous congestion. Lack of standardized methods for quantifying venous congestion. Difficulty in separating or grouping exploratory studies into discrete categories.

    Characterizing the molecular landscape of venous congestion · 2026 · DOI

  • Patients with physical limitations may have difficulty remaining in the orthostatic position. The orthostatic position may cause discomfort and increase the risk of adverse events. Alternative positions and maneuvers are needed to improve patient comfort and diagnostic accuracy.

    Eco-doppler venoso de membros inferiores · 2026 · DOI

  • The disease is frequently diagnosed at advanced stages. The treatment of the disease can be challenging due to its complexity and the need for a multidisciplinary approach. The prevention of the disease requires a comprehensive understanding of the risk factors associated with its development.

    Características Clínicas y Epidemiológicas de la Insuficiencia Venosa Crónica en una Cohorte Ambulatoria · 2026 · DOI

  • The need to understand the clinical and epidemiological characteristics of chronic venous insufficiency in order to improve diagnosis and treatment. The lack of studies that analyze the demographic characteristics, risk factors, and clinical manifestations of the disease in a large cohort of patients.

    Características Clínicas y Epidemiológicas de la Insuficiencia Venosa Crónica en una Cohorte Ambulatoria · 2026 · DOI

  • Long-term follow-up studies to evaluate the durability of EVLA treatment. Comparative studies to evaluate the effectiveness of EVLA versus other treatment options.

    Venous Clinical Severity Score as a Tool to Assess the Outcome of Endovenous Laser Ablation for Varicose Veins · 2026 · DOI

  • The lack of a sensitive tool to detect changes in disease severity over time. The need for a dynamic tool to objectively evaluate the severity of chronic venous insufficiency.

    Venous Clinical Severity Score as a Tool to Assess the Outcome of Endovenous Laser Ablation for Varicose Veins · 2026 · DOI

  • There is a need for efficient, safe, and rapid-recovery treatment options for lower extremity varicose veins. Traditional HL/S has limitations, including longer operation times and higher complication rates.

    Endovenous thermal ablation combined with foam sclerotherapy is a safe and effective method for the treatment of lower extremity varicose veins: a multicenter retrospective analysis · 2026 · DOI

  • The paper identifies a gap in awareness about potential causes of leg swelling after antibiotic intake.

    Geschwollenes Bein nach Antibiotika-Einnahme – ein Fall für die phlebologische Sprechstunde? · 2026 · DOI

  • The paper identifies a gap in the existing literature on the concept of truthlikeness. The paper identifies a need for a new measure of truthlikeness that can capture the distinction between lawlike and accidental information about the world.

    Verisimilitude vs. legisimilitude · 1983 · DOI

  • Diagnosing varicocele can be challenging due to its asymptomatic nature. Treating varicocele can be challenging due to the risk of complications. There is a need for a standardized treatment approach for varicocele.

    VARIKOCELĖS KLINIKINIAI POŽYMIAI, DIAGNOSTIKA, GYDYMO GALIMYBĖS · 2026 · DOI

  • There is a need for a comprehensive review of varicocele diagnosis and treatment. Current research on varicocele is limited by the lack of a standardized treatment approach.

    VARIKOCELĖS KLINIKINIAI POŽYMIAI, DIAGNOSTIKA, GYDYMO GALIMYBĖS · 2026 · DOI

  • CDU has limitations in detecting venous abnormalities in the pelvic and calf regions. CDU was severely limited by patient obesity in 40% of cases. The study had a limited sample size of 100 patients.

    Comparison of the diagnostic utility of computed tomography venography with color Doppler ultrasound in patients suspected of secondary varicose veins: Study on diagnostic accuracy · 2026 · DOI

  • Further studies are needed to evaluate the long-term outcomes of patients diagnosed with secondary varicose veins using CTV. Further studies are needed to compare the diagnostic accuracy of CTV with other imaging modalities.

    Comparison of the diagnostic utility of computed tomography venography with color Doppler ultrasound in patients suspected of secondary varicose veins: Study on diagnostic accuracy · 2026 · DOI

  • Diagnosing varicose veins during pregnancy can be challenging due to the physical changes that occur during pregnancy. Treating varicose veins during pregnancy can be challenging due to the risk of complications. Preventing varicose veins during pregnancy can be challenging due to the lack of awareness about the condition.

    HOMILADORLIKDA VARIKOZ KASSALIKLARI DIAGNOSTIKA: SABABLARI, TURLARI, KLINIK KO'RINISHLARI VA DAVOLASH YONDOSHUVI · 2026 · DOI

  • The study had a limited sample size, with only 311 participants involved in a comparison of Endovenous Laser Ablation and surgery. The study had a high risk of bias, with some outcomes assessed by non-blinded assessors.

    HOMILADORLIKDA VARIKOZ KASSALIKLARI DIAGNOSTIKA: SABABLARI, TURLARI, KLINIK KO'RINISHLARI VA DAVOLASH YONDOSHUVI · 2026 · DOI

  • Further well-designed clinical trials are required to validate efficacy and safety. Studies should investigate the effectiveness of integrative approaches combining modern and Ayurvedic strategies.

    RAKTAMOKSHANA & SIRAVYADHA IN VARICOSITY: HEMODYNAMIC AND SYMPTOMATIC OUTCOMES WITH COMPARATIVE EVALUATION OF SCLEROTHERAPY AND AYURVEDIC MANAGEMENT · 2026 · DOI

  • Existing studies have investigated compression therapy within individual pathologies, making it difficult to translate clinical findings into general design principles. There is a need to identify cross-pathological overarching insights that provide unified principles for compression device design.

    Compression Therapy in Human Body Applications: A Systematic Review from Principles to Practice · 2026 · DOI

  • The study's findings may contribute to the strategic planning of future CVI research by identifying underrepresented regions. The study's findings may guide the development of new international collaborations. The study's findings may support a more balanced allocation of research priorities.

    Bibliometric analysis of chronic venous insufficiency publications in web of science database · 2026 · DOI

  • The study identifies a gap in the research on chronic venous insufficiency, particularly in terms of the concentration of research in high-income countries. The study demonstrates that CVI research is predominantly concentrated in high-income countries.

    Bibliometric analysis of chronic venous insufficiency publications in web of science database · 2026 · DOI

  • There is a lack of standardization in patient positioning during duplex ultrasonography. Prior studies have not thoroughly evaluated the effect of patient positioning on duplex ultrasound findings.

    EFFECT OF PATIENT POSITION ON HEMODYNAMIC AND ANATOMICAL ASSESSMENT OF LOWER-LIMB VARICOSE VEINS USING DUPLEX ULTRASONOGRAPHY · 2026 · DOI

  • The study requires a comprehensive assessment of long-term outcomes and safety. The study needs to be conducted with larger patient cohorts and extended follow-up periods.

    EFFICACY OF ENDOVENOUS LASER ABLATION IN THE TREATMENT OF VENOUS TROPHIC ULCERS · 2026 · DOI

  • Conventional treatment modalities often prove insufficient for treating trophic ulcers. There is a need for effective treatment options for patients with trophic ulcers of venous aetiology.

    EFFICACY OF ENDOVENOUS LASER ABLATION IN THE TREATMENT OF VENOUS TROPHIC ULCERS · 2026 · DOI

Most-cited papers in Diagnosis and Treatment of Venous Diseases

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62 open questions have been extracted from the limitations and future-work passages of 359 Diagnosis and Treatment of Venous Diseases papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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