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Open research questions in Drug Transport and Resistance Mechanisms

97 unresolved questions extracted from the limitations and future-work sections of 345 Drug Transport and Resistance Mechanisms papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • the efficiency of the extraction protocol used for tissue samples was lower, - the study used a limited number of samples, - the study was performed in a specific cell line and mouse model

    Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease · 2026 · DOI

  • Limited therapeutic options for progressive familial intrahepatic cholestasis type 3. Lack of understanding of molecular drivers of disease progression. Need for novel pharmacological strategies.

    Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease · 2026 · DOI

  • The current understanding of the pathophysiological mechanisms of ICP is limited. The relationship between maternal bile acid concentrations and neonatal morbidity is not well understood. The effectiveness of established and emerging therapeutic interventions for ICP is not well established.

    Intrahepatic Cholestasis of Pregnancy: Neonatal Impact Through the Lens of Current Evidence · 2025 · DOI

  • Although ursodeoxycholic acid (UDCA) improves maternal pruritus and selected biochemical indices, its effect on major perinatal outcomes remains uncertain.

    Molecular Mechanisms of the Gut–Liver–Placenta Axis in Intrahepatic Cholestasis of Pregnancy: Microbiota-Associated Pathogenesis and Next-Generation Therapeutic Strategies · 2026 · DOI

  • Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether hyperlactatemia exacerbates hepatic ischemia-reperfusion injury (IRI) after donor liver implantation remains unclear.

    The Lactate‐Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM‐Dependent Mitochondrial Fatty Acid Synthesis · 2025 · DOI

  • BACKGROUND: Evidence concerning the association between excessive total bile acid (TBA) concentrations and adverse perinatal outcomes in the recent Chinese guidelines for intrahepatic cholestasis of pregnancy (C-ICP), which recommend including asymptomatic hypercholanemia of pregnancy (AHP) in ICP management, is insufficient.

    Total bile acid concentrations and adverse perinatal outcomes in chinese intrahepatic cholestasis of pregnancy including asymptomatic hypercholanemia of pregnancy: a retrospective cohort study · 2025 · DOI

  • Although the ICP has been associated with various fetal complications, its effects on maternal coagulation are poorly understood.

    Intrahepatic cholestasis of pregnancy and coagulation: a dual risk of hypercoagulability and bleeding · 2025 · DOI

  • While ursodeoxycholic acid (UDCA) is considered first-line therapy, optimal strategies for managing extreme, treatment-refractory cases remain inadequately defined.

    Bezafibrate for severe refractory intrahepatic cholestasis of pregnancy: a case report and literature review · 2025 · DOI

  • BACKGROUND: The etiology of intrahepatic cholestasis of pregnancy (ICP) is not fully understood; however, genetic, hormonal, environmental factors, and inflammation are believed to contribute to its development.

    Predictive value of inflammatory indices for disease severity and perinatal outcomes in intrahepatic cholestasis of pregnancy · 2025 · DOI

  • Abstract Description The metabolic landscape of cancer significantly influences anti-tumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance.

    Bile acids impedes tumor-specific T cell responses by modulating organelle-specific stress response 2754 · 2025 · DOI

  • Introduction: Bile acids (BAs) are central to host-microbiota interactions, yet their metabolism in wild rodents remains poorly characterized.

    Enterocytozoon bieneusi infection disrupts bile acid metabolism in the wild rodent gut microbiota: adaptive shifts in microbial metabolism and community structure · 2025 · DOI

  • Ursodeoxycholic acid remains the most widely used pharmacologic agent for maternal symptom relief, although evidence supporting neonatal benefit is inconclusive.

    Intrahepatic Cholestasis of Pregnancy: Neonatal Impact Through the Lens of Current Evidence · 2025 · DOI

  • Additionally, many small molecules reported in the literature to target SLCs are poorly characterized.

    Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily · 2024 · DOI

  • They represent an important therapeutic target class that remains only partly exploited as therapeutics that target SLCs are scarce.

    Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily · 2024 · DOI

  • subtilis and illuminate areas in which further experimental structural validation is warranted.

    Genome wide structural prediction of ABC transporter systems in Bacillus subtilis · 2024 · DOI

  • However, the precise mechanisms of AC inhibiting colon cancer, particularly in relation to the gut microbiome and bile acid dynamics, are not fully understood.

    Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression · 2024 · DOI

  • Little is known about how it specifically affects pregnancies resulting from in vitro fertilization (IVF).

    Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization · 2024 · DOI

  • BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, yet its influence on offspring growth remains unclear.

    The impact of maternal intrahepatic cholestasis during pregnancy on the growth trajectory of offspring: a population-based nested case‒control cohort study · 2024 · DOI

  • The regulation of microbial production of secondary BAs is not well understood, particularly the production of 7-dehydroxylated BAs, which are the most potent agonists for host BA receptors.

    Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid · 2024 · DOI

  • Foam cells, a lipid-rich cell-type, are considered critical for granuloma formation; however, the causative factor in foam cell formation remains unclear.

    Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation · 2024 · DOI

  • However, the exact mechanism by which LolCDE recognizes and transfers lipoprotein between domains remains unclear.

    Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE · 2024 · DOI

  • Analyzing bile acids in biological samples is challenging due to their endogenous nature. Investigating the pharmacokinetics and effects of golden bile powder is challenging due to the lack of a suitable analytical method.

    Pharmacokinetics and homeostatic impact of golden bile powder: evidence from surrogate analyte-based UPLC-MS/MS in rats · 2026 · DOI

  • The pharmacokinetics and effects of golden bile powder on endogenous bile acid homeostasis are unclear. There is a need for a new approach to analyze bile acids in biological samples.

    Pharmacokinetics and homeostatic impact of golden bile powder: evidence from surrogate analyte-based UPLC-MS/MS in rats · 2026 · DOI

  • Further research is needed to understand the pharmacological mechanisms of ivermectin hypersensitivity in birds. The study of the ABCB1 transporter in birds could provide insights into the evolution of drug sensitivity. Further research could investigate the role of the ABCB1 transporter in other bird species.

    Cloning, structural and functional characterization of the ABCB1 transporter of the Eurasian bullfinch (Pyrrhula pyrrhula) · 2026 · DOI

  • The underlying cause and pharmacological mechanism of ivermectin hypersensitivity in birds are not well understood. The role of the ABCB1 transporter in birds is not well studied.

    Cloning, structural and functional characterization of the ABCB1 transporter of the Eurasian bullfinch (Pyrrhula pyrrhula) · 2026 · DOI

Most-cited papers in Drug Transport and Resistance Mechanisms

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97 open questions have been extracted from the limitations and future-work passages of 345 Drug Transport and Resistance Mechanisms papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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