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Open research questions in Endometrial and Cervical Cancer Treatments

157 unresolved questions extracted from the limitations and future-work sections of 544 Endometrial and Cervical Cancer Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The prognostic relevance of surgical staging in patients with high-intermediate-risk and high-risk endometrial cancer remains uncertain.

    Long-term prognostic value of staging surgery for high-intermediate-risk and high-risk endometrial cancer · 2026 · DOI

  • Detection may include magnetic resonance imaging, positron emission tomography (PET) combined with CT scan, ultrasound, or biopsies; however, no agreement about the best method and time point has been reached.

    Biopsy‐proven residual cervical cancer at the end of combined chemoradiation predicts poor outcome—Retrospective single‐center cohort study · 2025 · DOI

  • To ensure that the results from research and quality assurance reports using SQRGC data are robust and reliable, the accuracy and completeness of the register need to be validated.

    Validation of data quality in the Swedish quality register of gynecologic cancer for cervical cancer and vulvar cancer—a Swedish gynecologic cancer group (Swe‐ GCG ) study · 2025 · DOI

  • BACKGROUND: Perimenopausal women are a high-risk group for gynecological cancers; however, the spatiotemporal heterogeneity in prevalence and its association with socioeconomic development have not been fully explored.

    Health inequality and improvement gap in the prevalence of gynecological cancers among perimenopausal women globally, 1990–2019 · 2025 · DOI

  • Conclusions: Sentinel lymph node biopsy is a safe and effective method for staging early-stage endometrial cancer and atypical hyperplasia, with low metastasis rates, but future research should focus on identifying patients who would benefit most from this procedure, considering its costs and required expertise.

    Sentinel Lymph Node in Endometrial Hyperplasia: State of the Art and Future Perspectives · 2025 · DOI

  • Plan quality indices such as Dose Homogeneity Index (DHI), Overdose Index (OI), Dose Non-uniformity Ratio (DNR), and Conformity Index (COIN) are crucial in evaluating treatment plans, yet their predictive clinical relevance remains underexplored.

    Evaluation and Clinical Relevance of Plan Quality Indices in Intracavitary Brachytherapy for Cervical Cancer · 2025 · DOI

  • Background: Cervical cancer remains to be a significant health concern globally, with India contributing to nearly one-quarter of cases worldwide.

    Evaluation and Clinical Relevance of Plan Quality Indices in Intracavitary Brachytherapy for Cervical Cancer · 2025 · DOI

  • Future research should focus not only on understanding the impact of surgical escalation on patients (including disease outcomes, quality of life, and equitable access to these services), but also on surgical training.

    Surgical Deescalation Within Gynecologic Oncology · 2025 · DOI

  • These findings support broader consideration of RAH as a safe and effective minimally invasive approach for EC management in real-world practice, although further long-term evaluation is warranted.

    Real-world outcomes of robotic and non-robotic hysterectomy for endometrial cancer: insights from a national cohort · 2025 · DOI

  • However, its impact on patient-reported outcomes and their quality of life remains underexplored.

    The effect of robot-assisted surgery on the gynecology patients’ experience and quality of life after surgery · 2025 · DOI

  • Although there are inconclusive data regarding the implication of waiting times for EC,2-4 we did not find literature regarding waiting times for patients with EAH.

    Time interval from biopsy of endometrial atypical hyperplasia to surgery and risk for concurrent endometrial carcinoma – A retrospective study · 2024 · DOI

  • The main limitations of this study are its retrospective nature and the possibility of referral bias, and its relatively small sample size.

    Time interval from biopsy of endometrial atypical hyperplasia to surgery and risk for concurrent endometrial carcinoma – A retrospective study · 2024 · DOI

  • Background: Despite extensive literature on therapeutic strategies for cervical cancer, a bibliometric analysis specifically focused on immunotherapy for advanced, recurrent, or metastatic (A/R/M) cervical malignancies remains unexplored.

    A comprehensive bibliometric analysis (2000–2022) on the mapping of knowledge regarding immunotherapeutic treatments for advanced, recurrent, or metastatic cervical cancer · 2024 · DOI

  • However, the relationships between metabolic disorders and the progression of EC remain uncertain.

    Association between metabolic disorders and clinicopathologic features in endometrial cancer · 2024 · DOI

  • Several issues that remain to be debated in the literature were addressed and compared, highlighting similarities and differences, from the role of the sentinel lymph node in early stages to that of the adjuvant hysterectomy in locally advanced tumors.

    Management for Cervical Cancer Patients: A Comparison of the Guidelines from the International Scientific Societies (ESGO-NCCN-ASCO-AIOM-FIGO-BGCS-SEOM-ESMO-JSGO) · 2024 · DOI

  • There is no consensus on adjuvant treatment in ITC patients at otherwise low risk, and their recurrence rate is low.

    Low-Volume Metastases in Apparent Early-Stage Endometrial Cancer: Prevalence, Clinical Significance, and Future Perspectives · 2024 · DOI

  • However, the benefits of adjuvant surgery after neoadjuvant treatments remain a debated issue and a still open question in the literature.

    Locally Advanced Cervical Cancer: Neoadjuvant Treatment versus Standard Radio-Chemotherapy—An Updated Meta-Analysis · 2024 · DOI

  • Endometrioid carcinoma with sex cord-like formations and hyalinization of the uterine corpus, or corded and hyalinized endometrioid adenocarcinoma (CHEC), is a rare morphological variant of endometrioid carcinoma, for which there is limited literature and few cases reports.

    Endometrioid carcinomas with sex cord-like formations and hyalinization: spontaneous pregnancy after conservative treatment · 2024 · DOI

  • This hypothesis-generating observation in patients with low-risk endometrial cancer warrants further investigation, especially with prospective setting.

    Lymph Node Isolated Tumor Cells in Patients With Endometrial Cancer · 2024 · DOI

  • There is a need to identify readily available biomarkers predictive of immunotherapy resistance in advanced cervical cancer. The underlying mechanisms of resistance to PD-1 inhibitors are not well understood.

    Baseline inflammatory and metabolic indicators associated with early PD-1 inhibitor resistance in advanced cervical cancer: a retrospective cohort study · 2026 · DOI

  • The study had a limited sample size of 62 patients. The study only evaluated the effect of bladder volume control on setup errors and dosimetry, and did not consider other factors that may affect treatment outcomes.

    Impact of bladder volume precision control on setup errors and dosimetry in intensity-modulated radiation therapy for cervical cancer · 2026 · DOI

  • The dynamic deformation of pelvic organs remains a bottleneck for dose delivery accuracy in IMRT for cervical cancer. There is a need for a reliable and accurate method to control bladder volume in IMRT for cervical cancer.

    Impact of bladder volume precision control on setup errors and dosimetry in intensity-modulated radiation therapy for cervical cancer · 2026 · DOI

  • There is a need to identify patients who are less likely to respond to chemoradiation therapy. There is a need to develop more personalized and effective treatment strategies for LACC.

    Plasma proteomic biomarkers for predicting chemoradiation response in locally advanced cervical cancer · 2026 · DOI

  • The growing incidence rate of endometrial cancer poses a significant challenge for healthcare providers. The disease is often diagnosed at an advanced stage, reducing treatment options and survival rates. There is a need for further research on the risk factors and characteristics associated with endometrial cancer.

    ANALYSIS OF RISK FACTORS IN PATIENTS WITH ENDOMETRIAL CANCER · 2026 · DOI

  • There is a need for further research on the risk factors and characteristics associated with endometrial cancer. The current study aims to address this gap by investigating the relationship between the disease and various demographic and health factors.

    ANALYSIS OF RISK FACTORS IN PATIENTS WITH ENDOMETRIAL CANCER · 2026 · DOI

Most-cited papers in Endometrial and Cervical Cancer Treatments

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157 open questions have been extracted from the limitations and future-work passages of 544 Endometrial and Cervical Cancer Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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