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Open research questions in Fungal Infections and Studies

164 gap statements mined from Fungal Infections and Studies papers in our 4.5M-paper local library, which holds 745 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Cryptococcal disease is a significant health concern among persons living with HIV. The current treatment guidelines require an update. The dosing and infusion protocol for Liposomal Amphotericin B needs to be simplified.

    SAHCS Guideline for the prevention, diagnosis and management of cryptococcal disease among persons living with HIV: Update to induction treatment for cryptococcal meningitis · 2026 · DOI

  • High mortality rates and limited effectiveness of antifungal treatments. Incomplete characterization of the dynamics of cytokines in HIV-negative patients with CM. Need for targeted immunomodulatory strategies for the treatment of CM.

    Cerebrospinal fluid cytokine-driven immune responses in HIV-negative cryptococcal meningitis · 2026 · DOI

  • Future studies could explore the use of targeted immunomodulatory strategies for the treatment of CM. Further research could investigate the role of the identified cytokines in the immune response to Cryptococcus. Studies could also examine the potential of CSF cytokine profiling as a diagnostic tool for CM.

    Cerebrospinal fluid cytokine-driven immune responses in HIV-negative cryptococcal meningitis · 2026 · DOI

  • The coexistence of cryptococcal infection in untreated sarcoidosis is an uncommon phenomenon. There is a lack of awareness about the potential complication of pulmonary cryptococcosis in treatment-naïve sarcoidosis patients.

    Pulmonary sarcoidosis complicated with pulmonary cryptococcosis: a case report · 2026 · DOI

  • The limited understanding of the fundamental ecology of T. marneffei. The lack of knowledge on the antifungal susceptibility and stress tolerance of clinical and non-clinical T. marneffei strains.

    Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and diminished antifungal responsiveness relative to non-clinical strains · 2026 · DOI

  • Diagnosing histoplasmosis in non-endemic regions can be challenging due to underreporting and lack of awareness. Developing effective diagnostic tests and treatment strategies for histoplasmosis is crucial. Occupational exposure to disrupted soil and stagnant water can increase the risk of histoplasmosis.

    Histoplasmosis with mediastinal lymphadenopathy in an immunocompetent municipal water department employee in Texas: a case report · 2026 · DOI

  • Histoplasmosis is not traditionally endemic to Texas, and prior studies have underestimated the true prevalence of the disease. There is a need for increased awareness of occupational fungal infections, even among healthy, working-age adults.

    Histoplasmosis with mediastinal lymphadenopathy in an immunocompetent municipal water department employee in Texas: a case report · 2026 · DOI

  • The underlying biology of the microbe-host interaction in CME has yet to be thoroughly explored. The mechanisms of intracranial hypertension in CME are not well understood.

    Pathophysiology of intracranial hypertension in cryptococcal meningoencephalitis · 2026 · DOI

  • The lack of understanding of the role of immunogenetic predisposition in the development of the disease.

    Paracoccidioidomicose Disseminada Grave com Ascite Quilosa e Lesão Cutânea em Mulher Imunocompetente: Relato de Caso · 2026 · DOI

  • Given that secondary infections are common and may account for up to 20% of deaths in autoimmune PAP, prompt and aggressive treatment is warranted.

    Autoimmune Pulmonary Alveolar Proteinosis in a Patient With Chronic Disseminated Blastomycosis: A Case Report · 2026 · DOI

  • The diagnosis of histoplasmosis can be challenging due to the rarity of the disease and the lack of specific clinical and laboratory findings. The treatment of histoplasmosis can be complicated by the presence of immunosuppression and the risk of complications.

    Histoplasmosis crónica diseminada en paciente inmunosuprimida con presentación clínica centrofacial · 2026 · DOI

  • The paper addresses the need to investigate the formation and characteristics of ovoid cells.

    Ovoid cell is an inducible small-sized morphotype that enhances proliferation and antifungal drug tolerance in the human fungal pathogen Cryptococcus neoformans · 2026 · DOI

  • There is a lack of reported cases of disseminated histoplasmosis in non-HIV patients. The study highlights the importance of considering histoplasmosis in the differential diagnosis of patients with oral and intestinal symptoms.

    Disseminated Histoplasmosis with Oral and Intestinal Manifestations in a Non-HIV Patient: Case Report · 2026 · DOI

  • There is a need for increased awareness of the potential for fulminant cryptococcal meningoencephalitis in immunocompetent patients. There is a lack of understanding of the disease's severity and prognosis in immunocompetent patients.

    Fulminant cryptococcal meningoencephalitis with adrenal involvement in an immunocompetent patient: a clinicopathologic correlation · 2026 · DOI

  • Post-transcriptional regulation is key to development, and yet little is known about how RNA isoform choice contributes to developmental choices in fungi.

    Temperature-driven isoform switching reprograms developmental gene expression in a human fungal pathogen · 2026 · DOI

  • Further investigations into the pathogenesis and dissemination pathways of the infection are needed. Studies on the clinical presentation of cutaneous cryptococcosis mimicking keratoacanthoma are necessary.

    Beyond the usual suspects - disseminated cryptococcosis presenting as molluscoid skin lesions: A case report · 2026 · DOI

  • There is a lack of published reports describing cryptococcosis clinically resembling keratoacanthoma. The pathogenesis and dissemination pathways of the infection are not fully understood.

    Beyond the usual suspects - disseminated cryptococcosis presenting as molluscoid skin lesions: A case report · 2026 · DOI

  • The previous guideline did not provide a simplified dosing and infusion protocol for Liposomal Amphotericin B.

    SAHCS Guideline for the prevention, diagnosis and management of cryptococcal disease among persons living with HIV: Update to induction treatment for cryptococcal meningitis · 2026 · DOI

  • Repeated invasive procedures can be difficult to implement in high-burden, resource-limited settings. Adjunctive pharmacologic approaches have not translated well from other intracranial hypertension syndromes.

    Pathophysiology of intracranial hypertension in cryptococcal meningoencephalitis · 2026 · DOI

  • Like other pathogens, fungal phytopathogens have evolved mechanisms for their survival in the host, which involve nutrient uptake, colonization, and reproduction.

    Mechanism of Virulence in Fungal Pathogens with Diverse Modes of Living · 2026 · DOI

  • The paper reports a single case of chronic disseminated histoplasmosis, which may not be representative of all cases. The diagnosis and treatment of the disease may be limited by the availability of resources and expertise in some settings.

    Histoplasmosis crónica diseminada en paciente inmunosuprimida con presentación clínica centrofacial · 2026 · DOI

  • Estudos sobre a eficácia de medidas de controle ambiental e manejo populacional de gatos ferais. Análise da relação entre a criptococose e outras doenças em gatos.

    REVISÃO DE LITERATURA - CRIPTOCOCOSE EM FELINOS FERAIS E ASSELVAJADOS · 2026 · DOI

  • Falta de conhecimento sobre a criptococose em gatos ferais e asselvajados. Necessidade de estudos sobre a transmissão da doença e seu impacto na saúde pública.

    REVISÃO DE LITERATURA - CRIPTOCOCOSE EM FELINOS FERAIS E ASSELVAJADOS · 2026 · DOI

  • Further investigation into the role of immunogenetic predisposition in the development of paracoccidioidomycosis. Study of the treatment outcomes of chronic disseminated paracoccidioidomycosis.

    Paracoccidioidomicose Disseminada Grave com Ascite Quilosa e Lesão Cutânea em Mulher Imunocompetente: Relato de Caso · 2026 · DOI

  • Larger studies are needed to confirm the findings, - Further evaluation of isavuconazole's effectiveness in treating other fungal infections, - Assessment of isavuconazole's pharmacokinetics…

    Use of Isavuconazole in the Treatment of Cryptococcosis: A Real-World Case Series · 2026 · DOI

Most-cited papers in Fungal Infections and Studies

Most recent work

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Open questions raised by papers listed on this page include: (1) Future studies could explore the use of targeted immunomodulatory strategies for the treatment of CM (“Cerebrospinal fluid cytokine-driven immune responses in HIV-negative…”, 2026); (2) There is a lack of awareness about the potential complication of pulmonary cryptococcosis in treatment-naïve sarcoidosis patients (“Pulmonary sarcoidosis complicated with pulmonary cryptococcosis: a case report”, 2026); (3) The lack of knowledge on the antifungal susceptibility and stress tolerance of clinical and non-clinical T. marneffei strains (“Clinical Talaromyces marneffei isolates exhibit enhanced stress tolerance and…”, 2026); (4) Diagnosing histoplasmosis in non-endemic regions can be challenging due to underreporting and lack of awareness (“Histoplasmosis with mediastinal lymphadenopathy in an immunocompetent municipal…”, 2026); (5) The mechanisms of intracranial hypertension in CME are not well understood (“Pathophysiology of intracranial hypertension in cryptococcal meningoencephalitis”, 2026). 164 gap statements have been mined from Fungal Infections and Studies papers in our 4.5M-paper local library, which holds 745 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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