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Open research questions in Gastrointestinal disorders and treatments

44 unresolved questions extracted from the limitations and future-work sections of 256 Gastrointestinal disorders and treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The available evidence is limited to case reports and small case series. No inferential statistics or meta-analytic pooling were attempted due to heterogeneity of report types and sample size constraints. The study is subject to biases inherent in case reports and small case series.

    Excluded-stomach Perforation after Roux-en-Y and One-anastomosis Gastric Bypass: A Systematic Review with Video-illustrated Case Report · 2026 · DOI

  • Further studies are needed to understand the incidence and risk factors of gastric remnant or duodenal perforation after RYGB and OAGB. Research should focus on the development of effective diagnostic and management strategies for this complication.

    Excluded-stomach Perforation after Roux-en-Y and One-anastomosis Gastric Bypass: A Systematic Review with Video-illustrated Case Report · 2026 · DOI

  • The rarity of transverse colon herniation due to its stable anatomical fixation. The lack of understanding of the pathological mechanisms underlying this rare clinical entity.

    Case Report: Strangulated transverse colon inguinal hernia complicated by cecal perforation in a patient with sclerosing mesenteritis · 2026 · DOI

  • Delayed diagnosis may lead to serious complications. The classic triad of abdominal pain, vomiting, and bloody stools is not simultaneously present in all patients. The need for a reliable and accurate diagnostic method.

    Pediatric Intussusception: A Single-Center Experience · 2026 · DOI

  • Delayed diagnosis due to misinterpretation of radiological findings. The need for prompt surgical intervention to prevent catastrophic outcomes. The importance of maintaining awareness of fecal impaction as a complication of chronic constipation.

    Massive Fecal Impaction with Megacolon Mimicking Perforation Peritonitis. A Case Report and Review of Literature. · 2026 · DOI

  • Diagnosing gossypiboma can be challenging due to its variable presentation. Treating gossypiboma can be challenging due to the risk of life-threatening complications. Preventing gossypiboma can be challenging due to the need for effective methods for counting and tracking surgical sponges.

    Incidental Diagnosis of a Gossypiboma With Complete Transmural Migration Into the Jejunum After a Hysterectomy: A Case Report · 2026 · DOI

  • Further study is needed to characterize the relationship between amyloidosis and lymphatic abnormalities. Additional case reports or studies are needed to better understand the coexistence of small bowel lymphangiomatosis and AA-dominant amyloidosis.

    Small Bowel Lymphangiomatosis Presenting With Amyloidosis: A Case Report · 2026 · DOI

  • There is a lack of documentation on unexpected postoperative complications associated with the Swenson procedure. Intussusception is a rare but possible complication of the Swenson procedure.

    Acute ileo-ileal intussusception following a Swenson procedure in a resource-limited setting: a case report · 2026 · DOI

  • High rates of morbidity and mortality. Delayed presentation. Limited awareness of risk factors and etiology.

    A Study of Clinical Evaluation and Management of Gastro-Intestinal Perforations · 2026 · DOI

  • A negative CT finding does not definitively exclude internal hernia; diagnostic laparoscopy may be considered in symptomatic patients with pertinent surgical history.

    Case Report: A rare cause of acute abdomen: retrograde efferent loop intussusception into the gastric remnant following Billroth II gastrectomy · 2026 · DOI

  • This report is limited by the absence of EUS and EUS- FNA, which restricted pre-operative diagnostic certainty and influenced the decision to proceed with resectional surgery.

    One Anastomosis Gastric Bypass with Remnant Stomach Resection for an Undiagnosed Gastric Lesion: A Case Report · 2026 · DOI

  • The management of giant Meckel's diverticulum within an incarcerated hernia remains controversial. The use of prosthetic mesh in clean-contaminated fields is debated.

    Incarcerated Littre’s Inguinal Hernia Containing a Giant Meckel’s Diverticulum Managed with Lichtenstein Mesh Hernioplasty · 2026 · DOI

  • While computed tomography (CT) may assist in identifying the diverticulum within the hernia sac, its routine application in emergent scenarios is often limited by the urgency of surgical intervention (6).

    Incarcerated Littre’s Inguinal Hernia Containing a Giant Meckel’s Diverticulum Managed with Lichtenstein Mesh Hernioplasty · 2026 · DOI

  • A major strength of this case is the correlation between the features of operative findings and the histopathological fibrosis-dominant SM. However, as a single case report, this insufficient to establish a definitive observation remains causal transverse colon herniation, and direct literature support for this mechanism remains limited.

    Case Report: Strangulated transverse colon inguinal hernia complicated by cecal perforation in a patient with sclerosing mesenteritis · 2026 · DOI

  • Gastroduodenal intussusception is an extremely rare event in adults, and there is a lack of reported cases. The etiologies of gastroduodenal intussusception are not well understood.

    A case report of gastroduodenal intussusception caused by gastric gastrointestinal stromal tumor · 2026 · DOI

  • Despite advances in diagnostic modalities and surgical techniques, gastrointestinal perforation continues to be associated with high morbidity and mortality.

    A Study of Clinical Evaluation and Management of Gastro-Intestinal Perforations · 2026 · DOI

  • The pathophysiology of adult intussusception remains incompletely understood. The presence of multiple simultaneous small bowel intussusceptions is exceedingly rare.

    Multiple Transient Idiopathic Small Bowel Intussusceptions in an Adult: A Rare Intraoperative Finding · 2026 · DOI

  • The internal migration of a FJ tube is a rare clinical entity. There is a need for effective and minimally invasive approaches to retrieve migrated tubes.

    Successful Colonoscopic Retrieval of a Migrated Feeding Jejunostomy Tube: A Minimally Invasive Approach · 2026 · DOI

  • However, the surgical theory centered on developmental anatomy remains to be improved, currently, the mastery of surgical procedures and the determination of dissection boundaries rely more on surgeons' clinical experience than on theoretical guidance, resulting in a disconnect between clinical practice and applied theory that limits the homogeneous promotion of these surgeries.

    [Basic research and clinical applications progress of gastrointestinal developmental anatomy surgery]. · 2026 · DOI

  • The exact etiology of alimentary tract duplications is yet to be determined. There is a lack of awareness of cecal duplication cysts among pediatric surgeons and radiologists.

    Cecal Duplication Cyst Presenting with Complications in Early Childhood: A Case Report · 2026 · DOI

  • The need for a study to evaluate the clinical, laboratory, radiological, and treatment characteristics of pediatric intussusception cases. The need to identify factors associated with surgical intervention.

    Pediatric Intussusception: A Single-Center Experience · 2026 · DOI

  • Intestinal intussusception is a rare cause of gastrointestinal obstruction in adults, and there is a need for expanded diagnosis. There is a lack of understanding of the association between Cowden syndrome and intestinal intussusception.

    Unusual presentation of small bowel obstruction in Cowden syndrome: A case report and literature review · 2026 · DOI

  • The studies had limited sample sizes and follow-up periods. The studies did not investigate the long-term outcomes of the different treatment strategies.

    Výběry z mezinárodních časopisů 2/2026 · 2026 · DOI

  • There is a need for more effective and sustainable treatment strategies for Barrett's esophagus, transjugular intrahepatic portosystemic shunt, and inflammatory bowel disease. The current treatment approaches have limitations and uncertainties.

    Výběry z mezinárodních časopisů 2/2026 · 2026 · DOI

  • The gap in the literature is the lack of awareness of the possibility of early presentation of internal hernia after LRYGB. The gap in clinical practice is the difficulty in diagnosing internal hernia in the early postoperative period due to nonspecific symptoms and misleading initial imaging.

    Early Presentation of Internal Hernia After Laparoscopic Roux-en-Y Gastric Bypass · 2026 · DOI

Most-cited papers in Gastrointestinal disorders and treatments

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44 open questions have been extracted from the limitations and future-work passages of 256 Gastrointestinal disorders and treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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