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Open research questions in Genomics, phytochemicals, and oxidative stress

87 unresolved questions extracted from the limitations and future-work sections of 225 Genomics, phytochemicals, and oxidative stress papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigate the effects of chamomile extract on other cancer cell lines, - Investigate the effects of chamomile extract in vivo, - Compare the effects of chamomile extract to other treatments

    Chamomile extract as a potential regulator of mitochondrial apoptosis and the Wnt/β-catenin pathway in AGS and KATO III cells · 2026 · DOI

  • the gap in which promising preclinical results fail to translate into human efficacy due to poor bioavailability, formulation instability and toxicity concerns, - the study by Tian et al. speculated that the association is attributed to reverse causation, - the untested hypothesis requires further validation, - the transition from the laboratory to population health is required for the ultimate validation of these therapeutics

    Editorial: Nutraceuticals modulation for oxidative stress in disease and health: volume II · 2026 · DOI

  • standardisation of extracts to ensure chemical reproducibility, - the microbiota-mediated transformation of nutraceuticals, - longitudinal human trials to establish definitive causal links between nutraceutical interventions and long-term health outcomes

    Editorial: Nutraceuticals modulation for oxidative stress in disease and health: volume II · 2026 · DOI

  • The lack of independent pen replicates limits the extent to which the observed effects can be attributed specifically to the dietary treatment, - The study was conducted under commercial farm conditions, - The results should be interpreted with due caution

    Dietary Lepidium meyenii Supplementation Is Associated with Hepatic Transcriptomic and Targeted DNA Methylation Changes in Pigs · 2026 · DOI

  • Achieving durable disease control in ulcerative colitis remains challenging. The complex interplay of genetic susceptibility, environmental factors, and gut microbiota imbalance in ulcerative colitis poses a challenge for therapeutic development. The study had to investigate the molecular dependence of Squalene's protective effect and the functional contribution of the gut microbiota.

    Squalene alleviates DSS-induced colitis by restoring Nrf2-dependent redox balance and gut microbiota homeostasis · 2026 · DOI

  • investigation of the molecular mechanisms underlying the protective effects of SQ, - evaluation of the therapeutic potential of SQ in human UC

    Squalene alleviates DSS-induced colitis by restoring Nrf2-dependent redox balance and gut microbiota homeostasis · 2026 · DOI

  • The need for stronger causal validation of Nrf2/HO-1 signaling in retinal neurodegenerative diseases. The requirement for improved ocular delivery and better cell type-specific targeting of therapeutic interventions.

    Nrf2/HO-1 signaling in retinal neurodegenerative diseases: redox homeostasis, cytoprotection, and therapeutic perspectives · 2026 · DOI

  • Current research on syringic acid is insufficient. Most studies lack systematic in vivo validation, appropriate positive controls, and mechanistic depth. The mechanisms underlying syringic acid's antioxidant activity remain inadequately elucidated.

    Unveiling the antioxidant and anti-inflammatory potential of syringic acid: mechanistic insights and pathway interactions · 2025 · DOI

  • The gradual onset of diabetic retinopathy makes it difficult to detect visual deficits in the early stages. The multifactorial nature of the disease makes it challenging to attribute the condition to a single pathogenic factor. The lack of effective and feasible therapeutic strategies for diabetic retinopathy.

    PSCP, a novel reactive sulfur donor, activates Keap1-Nrf2 signaling and attenuates mitochondrial dysfunction in diabetic retinopathy · 2025 · DOI

  • The lack of understanding of the molecular drivers of diabetic retinopathy. The need for effective and feasible therapeutic strategies. The limitations of current animal models in capturing the complexity of the disease.

    PSCP, a novel reactive sulfur donor, activates Keap1-Nrf2 signaling and attenuates mitochondrial dysfunction in diabetic retinopathy · 2025 · DOI

  • Yet, how the diversity of phytochemicals contributes to defense across different contexts of herbivory remains incompletely understood.

    Plants recognize identity and intensity of herbivores to adaptively reconfigure metabolism · 2026 · DOI

  • This approach enabled the exploration of a wide array of Brassica metabolites, notably by incorporating underexplored classes such as megastigmanes, phenolamides, and tetra/pentahexosylated acylated flavonoids.

    Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding · 2026 · DOI

  • BACKGROUND: Specialized metabolites play key roles in ecological interactions and stress responses, yet their diversification remains poorly understood in many crop species.

    Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding · 2026 · DOI

  • However, the cellular pathway for translating oxidative stress signals into Nrf2-dependent antioxidant responses remain incompletely understood.

    DNA damage response pathway regulates Nrf2 in response to oxidative stress · 2025 · DOI

  • Future research should address its pharmacokinetics, safety profile, and clinical potential.

    Unveiling the antioxidant and anti-inflammatory potential of syringic acid: mechanistic insights and pathway interactions · 2025 · DOI

  • However, the underlying molecular and biochemical mechanisms are still poorly understood.

    Prolonged heat stress in Brassica napus during flowering negatively impacts yield and alters glucosinolate and sugars metabolism · 2025 · DOI

  • However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.

    Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review · 2025 · DOI

  • The side chain diversity of glucosinolates results in a range of structurally distinct products, but how this chemical variation affects herbivores and their detoxification responses remains incompletely understood.

    Multiple glutathione-S-transferases detoxify diverse glucosinolate-based defenses of Brassicales plants in a generalist lepidopteran herbivore (Spodoptera littoralis) · 2025 · DOI

  • 4-Isothiocyanato-1-butene (4-BITC) is a crucial plant isothiocyanate; however, its flavor profile in microwave rapeseed oil and its anti-inflammatory properties have not been elucidated in detail.

    Flavor Profile of 4-Isothiocyanato-1-butene in Microwave Rapeseed Oil and Its Anti-Inflammatory Properties In Vitro · 2025 · DOI

  • One limitation in improving outcomes is the lack of a complete understanding of immune checkpoint regulation.

    The aryl hydrocarbon receptor controls IFN-γ-induced immune checkpoints PD-L1 and IDO via the JAK/STAT pathway in lung adenocarcinoma · 2025 · DOI

  • Abstract Description Rationale The role of Nrf2 in host defense against carbapenem-resistant Klebsiella pneumoniae (CRKP) (aka superbug) remains elusive.

    Nrf2 regulates host defense against carbapenem-resistant Klebsiella pneumoniae pneumonia through leukocyte homeostasis and function 2592 · 2025 · DOI

  • BACKGROUND: Given that there is not yet a fully effective treatment for Parkinson's disease (PD), further research into therapeutic agents is necessary to enhance PD patients' clinical performance and quality of life.

    Stigmasterol exerts antioxidant effects through activation of the Keap1/Nrf2 signaling pathway in Parkinson’s disease model · 2025 · DOI

  • Furthermore, this study paves the way for further investigation of sulforaphane and similar structures as pharmacophores for anti-QS candidates.

    Investigating Sulforaphane’s anti-virulence and anti-quorum sensing properties against Pseudomonas aeruginosa · 2024 · DOI

  • Introduction Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism spectrum disorders (ASD) has not been studied.

    Therapeutic efficacy of sulforaphane in autism spectrum disorders and its association with gut microbiota: animal model and human longitudinal studies · 2024 · DOI

  • However, the mechanism by which exogenous calcium influences flavonoid regulation in peanut roots under salt stress remains unclear.

    Effects of exogenous calcium on flavonoid biosynthesis and accumulation in peanut roots under salt stress through multi-omics · 2024 · DOI

Most-cited papers in Genomics, phytochemicals, and oxidative stress

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87 open questions have been extracted from the limitations and future-work passages of 225 Genomics, phytochemicals, and oxidative stress papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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