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Open research questions in Gout, Hyperuricemia, Uric Acid

132 unresolved questions extracted from the limitations and future-work sections of 340 Gout, Hyperuricemia, Uric Acid papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • investigation of the precise mechanistic networks linking BA dysmetabolism to gout, - development of novel therapeutic strategies targeting BA pathways

    Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies · 2025 · DOI

  • The precise mechanisms of bile acid metabolism in gout pathogenesis are not fully understood. There is a need for novel therapeutic strategies targeting underlying pathogenesis. The current understanding of bile acid-gout interactions is incomplete.

    Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies · 2025 · DOI

  • Further studies are needed to confirm the findings, - Longitudinal studies could provide more insight into the relationship between UHR and CKD, - Studies in other populations could determine if the findings are generalizable

    Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study · 2025 · DOI

  • The study aims to address the gap in understanding the relationship between uric acid to HDL cholesterol ratio and CKD in Chinese patients with T2DM. The gap in diagnostic markers for CKD is also addressed.

    Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study · 2025 · DOI

  • The study faced challenges in understanding the complex relationship between serum uric acid and biological aging. The study had to account for various covariates, including sex, age, and disease status. The study used a large dataset, but the analysis was limited by the availability of certain variables.

    The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts · 2025 · DOI

  • Investigate the mechanisms by which SUA influences the aging process, - Examine the relationship between SUA and aging in other populations, - Explore the potential for SUA-lowering therapies to slow aging, - Investigate the relationship between SUA and specific chronic diseases

    The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts · 2025 · DOI

  • Further exploration and validation of UHR as a risk factor for sarcopenia are needed. Investigation of the biological pathways through which uric acid affects muscle tissue is required

    Relationship between uric acid to high-density lipoprotein cholesterol ratio and sarcopenia in NHANES: exploring the mediating role of bilirubin and association with all-cause mortality · 2025 · DOI

  • The study faces challenges in accounting for the complex multi-stage stratified probability sampling design employed in NHANES. The study must address the issue of missing data for exposure-related indicators. The study needs to adjust for different covariates to provide accurate estimates of the associations between insulin resistance indicators and ASCVD with hyperuricemia.

    The association between insulin resistance-related markers and ASCVD with hyperuricemia: results from the 2005 to 2018 National Health and Nutrition Examination Survey · 2025 · DOI

  • One challenge is the risk of adverse events associated with conventional therapeutic approaches. Another challenge is the need for careful monitoring of patients with renal impairment. The paper also mentions the challenge of minimizing adverse effects and improving patient outcomes.

    Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions · 2024 · DOI

  • There is a need for novel therapeutic strategies that can reduce reliance on standard medications and minimize adverse effects. Conventional therapeutic approaches have limitations, and further research is warranted to validate emerging therapeutic strategies. The long-term efficacy of weight management strategies in reducing gout flares remains elusive.

    Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions · 2024 · DOI

  • Previous studies have often been limited by small sample sizes. Incomplete adjustment for metabolic and renal factors.

    Helicobacter pylori infection, hyperuricemia, and serum uric acid levels: The role of metabolic, renal, and inflammatory factors in a large health examination population · 2026 · DOI

  • pylori infection, insulin resistance, metabolic syndrome, and chronic low-grade inflammation, although the epidemiological evidence remains inconsistent [3].

    Helicobacter pylori infection, hyperuricemia, and serum uric acid levels: The role of metabolic, renal, and inflammatory factors in a large health examination population · 2026 · DOI

  • There is a need for early identification of high-risk populations and exploration of potential biomarkers for sarcopenia. The relationship between serum uric acid-to-creatinine ratio and sarcopenia risk is not well understood.

    Serum uric acid-to-creatinine ratio and sarcopenia risk under AWGS 2025 criteria: a nationwide study on the interaction with physical activity · 2026 · DOI

  • A link between environmental pollution and hyperuricemia has been identified, but the underlying mechanisms remain unknown.

    Aryl Hydrocarbon Receptor regulates uric acid homeostasis · 2026 · DOI

  • However, the relationships among the TyG index, obesity, and hyperuricemia in individuals with T2DM remain unclear.

    Association between the triglyceride-glucose index and hyperuricemia: potential role of obesity in patients with Type 2 diabetes mellitus · 2025 · DOI

  • There is a lack of studies on the association between the uric acid to high-density lipoprotein ratio and sarcopenia. The mediating role of oxidative stress factors and systemic inflammatory markers in this relationship is not well understood.

    Relationship between uric acid to high-density lipoprotein cholesterol ratio and sarcopenia in NHANES: exploring the mediating role of bilirubin and association with all-cause mortality · 2025 · DOI

  • Background The association between insulin resistance and the comorbidity of ASCVD with hyperuricemia remains to be further explored.

    The association between insulin resistance-related markers and ASCVD with hyperuricemia: results from the 2005 to 2018 National Health and Nutrition Examination Survey · 2025 · DOI

  • However, its association with hyperuricemia in early-stage CKM syndrome remains uncertain.

    Nonlinear association between triglyceride-glucose index and risk of hyperuricemia in early-stage cardiovascular-kidney-metabolic syndrome: a cross-sectional study of United States population · 2025 · DOI

  • Abstract Decreased renal uric acid excretion is a major contributor to hyperuricemia (HUA), but its underlying mechanism remains unclear.

    Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia · 2025 · DOI

  • Galangin, a polyphenolic compound found in Alpinia officinarum and propolis, has demonstrated the capacity to inhibit xanthine oxidase (XO) activity both in vitro and in silico; however, the precise mechanisms underlying its effects in vivo remain unclear.

    Galangin Protects against Hyperuricemia via Ameliorating Gut–Kidney Axis Dysfunction in Mice · 2025 · DOI

  • Pachymic acid, the primary active ingredient of the edible fungal herb Poria cocos, has demonstrated the protective capacity against renal injury, but its beneficial effect on hyperuricemic nephropathy remains unclear.

    Pachymic Acid Ameliorates Fructose-Driven Hyperuricemic Nephropathy in Mice by Suppressing Ferroptosis via Activating Nrf2/GPX-4 Pathway · 2025 · DOI

  • BACKGROUND: The relationship between serum uric acid (SUA) and adverse outcomes in advanced age remains poorly understood.

    Serum uric acid and the risk of major adverse cardiovascular events and death among older adults: a population-based prospective cohort study · 2025 · DOI

  • Future research should explore longitudinal impacts and intervention outcomes to further elucidate the potential benefits of uric acid management on muscle health.

    Inverse association between uric acid levels and muscle quality index in adults: a cross-sectional analysis of NHANES 2011–2014 · 2024 · DOI

  • Despite this, there is limited research on the potential connection between work shifts and abnormal serum uric acid (SUA) levels.

    The influence of night shift work and associated factors on serum uric acid in aircraft maintenance workers · 2024 · DOI

  • As a widely used traditional Chinese medicine, Euodiae fructus (ER) has strong anti-inflammatory and analgesic effects, however, its therapeutic effects on HUA and gout have not been investigated.

    Anti-inflammatory and uric acid lowering effects of Euodiae fructus on hyperuricemia and gout mice · 2024 · DOI

Most-cited papers in Gout, Hyperuricemia, Uric Acid

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132 open questions have been extracted from the limitations and future-work passages of 340 Gout, Hyperuricemia, Uric Acid papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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