Science AI Journal
Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Hippo pathway signaling and YAP/TAZ

91 unresolved questions extracted from the limitations and future-work sections of 163 Hippo pathway signaling and YAP/TAZ papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Ongoing research must be prioritized, focusing on the molecular mechanisms of tumor progression, metastasis, and drug resistance, - The identification of new therapeutic targets and the screening of specific biomarkers

    PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer · 2026 · DOI

  • The complex pathogenesis and tumor heterogeneity of cervical cancer make it urgent to investigate its pathological mechanisms. Advanced tumors often tend to metastasize and develop resistance to treatment, which frequently leads to poor patient prognosis. The identification of new therapeutic targets and the screening of specific biomarkers are crucial in overcoming this disease and improving patient outcomes.

    PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer · 2026 · DOI

  • While microtubule-associated protein 1S (MAP1S) is known to regulate autophagy, its role in the cardiac pathological conditions remains unclear.

    Microtubule-associated protein 1S (MAP1S): a cardioprotective factor against post-myocardial infarction remodeling via apoptosis inhibition · 2026 · DOI

  • Protein kinases control most cell signaling pathways and are highly actionable drug targets; however, systematic studies determining the kinases that underly the epithelial-mesenchymal polarity switch (EMPS) are lacking.

    Multi-Modal Kinome Profiling Discovers Mesenchymal-Like Polarity Networks that Underly Directed Hepatocellular Carcinoma Cell Migration · 2026 · DOI

  • However, the role of JDP2 in CRC, cell cycle homeostasis of colon cancer cells, and their fate remains poorly defined.

    Single-cell profiling reveals disruption of cell-cycle homeostasis following JDP2 depletion in colorectal epithelial cells · 2026 · DOI

  • We therefore distinguish among developmental, neonatal, vestibular, ex vivo , and adult in vivo evidence, and identify where current findings support, weaken, or remain insufficient to establish the biomechanical brake model.

    Hippo–YAP/TAZ signaling in inner ear development, injury, and regeneration: evidence synthesis and the biomechanical brake hypothesis · 2026 · DOI

  • The WNK-OSR1/SPAK protein kinase pathway regulates ion homeostasis and cell volume, but its other functions are not well understood.

    Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathway · 2025 · DOI

  • Deficiency of GS is associated with several neurological disorders including epilepsy, but the molecular mechanism underlying the control of GS expression and the mechanism of GS reduction in diseased brain remain elusive.

    Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways · 2025 · DOI

  • 3 , 4 , 9 However, it remains unclear whether other oncogenes can trigger MCC and whether growth is generally the only central regulator of MCC.

    Interfacial tension and growth both contribute to mechanical cell competition · 2025 · DOI

  • Although FRA1 has been linked to cancer progression, its role in early transformation and radiation responses remains unclear.

    FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks · 2025 · DOI

  • Maternal embryonic leucine zipper kinase (MELK), a serine/threonine kinase of the AMPK family, is known to regulate cell cycle and tumorigenesis, but its role in PAH remains unclear.

    Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling · 2025 · DOI

  • Further investigation of the immunologic response using single-cell sequencing and multispectral imaging revealed that tumor regression was associated with suppression of neutrophils and influx of effector CD8+ T cells.

    The Extracellular Niche and Tumor Microenvironment Enhance KRAS Inhibitor Efficacy in Pancreatic Cancer · 2024 · DOI

  • In addition, the correlation of cuproptosis-related genes and Hippo pathway-related genes with tumor prognosis warrants further investigation.

    Role of hippo pathway and cuproptosis-related genes in immune infiltration and prognosis of skin cutaneous melanoma · 2024 · DOI

  • Recent studies have unveiled PS-induced formation of several transcriptional factor (TF) condensates that are transcriptionally active, but how strongly PS promotes gene activation remains unclear.

    Phase separation of YAP-MAML2 differentially regulates the transcriptome · 2024 · DOI

  • We previously demonstrated that fucosyltransferase 2 (FUT2) promotes the malignancy of CRC cells, however, the underlying mechanisms remain unclear.

    FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1 · 2024 · DOI

  • While other mechanical factors, such as shear stress and circumferential stretch, have been extensively studied, little is known about the role of hydrostatic pressure in the regulation of endothelial cell behavior.

    Hydrostatic pressure drives sprouting angiogenesis via adherens junction remodelling and YAP signalling · 2024 · DOI

  • However, the role of cancer cell-intrinsic signaling in shaping the immunosuppressive TME remains unclear.

    Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment · 2024 · DOI

  • However, its expression and functional relationship of MAZ in melanoma have not been previously investigated.

    Molecular mechanisms of MAZ targeting up-regulation of NDUFS3 expression to promote malignant progression in melanoma · 2024 · DOI

  • Epiboly involves the mechano-transducer activity of yap1 but what are the regulators of yap1 activity and whether these are maternally or zygotically derived remain elusive.

    Maternal vgll4a regulates zebrafish epiboly through Yap1 activity · 2024 · DOI

  • However, the association between MST1 and mitochondrial function in AD remains unknown.

    MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway · 2024 · DOI

  • In conclusion, GPCRs are involved in each stage of the wound healing process with distinct roles and perform different functions. They play an important role in the regulation of immune responses in the inflammatory phase and cell proliferation and differentiation in the tissue regeneration phase during damage repair. Cutaneous wound repair and regeneration are mainly related to dermal Investigation, Writing – HC: Conceptualization, Writing – original draft, Visualization, Funding acquisition. KZ: Conceptualization, Writing – original review and editing, draft, Visualization. YX: Writing – Investigation. XF: Investigation, Writing – review and editing. CZ: editing. TZ: Writing – review and editing, Investigation. FL: Writing – review and editing, Supervision. HC: Writing – review and editing, Supervision. HZ: Writing – review and editing, Supervision. CD: Supervision, Writing – review and editing. WL: Supervision, Writing – review and editing. review and Frontiers in Cell and Developmental Biology 11 frontiersin.org Chen et al.

    GPCRs as key regulators in wound healing · 2026 · DOI

  • There is a lack of targeted approaches for ESCC treatment. There is a need to identify highly effective biomarkers for ESCC immunotherapy response.

    Proteome profiles of esophageal squamous cell carcinoma tie mitochondrial complex I to immunotherapy · 2026 · DOI

  • which was a valid alternative method to explore the impact of YAP1 on immunotherapy. The impact of genetic ablation of YAP1 on immunotherapy response in ESCC remains to be elucidated and warrants further investigation in future studies.

    Proteome profiles of esophageal squamous cell carcinoma tie mitochondrial complex I to immunotherapy · 2026 · DOI

  • The role of NELFA in regulating YAP transcription is unclear. The clinical relevance of NELFA in breast cancer is unknown.

    NELFA-mediated pausing restrains YAP transcription and context-dependent outcomes in breast cancer · 2026 · DOI

  • The precise mechanisms underlying the regulation of organ size during development and homeostasis remain unclear. The study aims to address this gap by investigating Vgll4-mediated Tead regulation.

    Two distinct modes of Vgll4-mediated Tead regulation control organ size in zebrafish · 2026 · DOI

Most-cited papers in Hippo pathway signaling and YAP/TAZ

Most recent work

Find a gap in your own Hippo pathway signaling and YAP/TAZ sub-topic

This page shows what the Hippo pathway signaling and YAP/TAZ literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Biochemistry, Genetics and Molecular Biology

Gut microbiota and health
1,024 open questions
Single-cell and spatial transcriptomics
602 open questions
Genetic Associations and Epidemiology
393 open questions
Antibiotic Resistance in Bacteria
360 open questions
Inflammatory Bowel Disease
353 open questions
Extracellular vesicles in disease
305 open questions
Mitochondrial Function and Pathology
296 open questions
Human-Animal Interaction Studies
294 open questions
91 open questions have been extracted from the limitations and future-work passages of 163 Hippo pathway signaling and YAP/TAZ papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.