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Open research questions in HIV-related health complications and treatments

46 unresolved questions extracted from the limitations and future-work sections of 263 HIV-related health complications and treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study faced challenges in terms of the limited generalizability of the findings due to the small sample size and single-site design. The study faced challenges in terms of the potential biases and limitations of using secondary data.

    Prevalence and associated factors of prediabetes among adults living with HIV receiving dolutegravir-based antiretroviral therapy in Zambia · 2026 · DOI

  • Metabolic complications are often cumulative over time. The management of lipid disorders among PLHIV is challenging due to the complexity of the disease. There is a need for effective strategies to manage lipid disorders among PLHIV.

    Antiretroviral therapy and lipid disorders among people living with HIV/AIDS in the West Region of Cameroon: a comparative cross-sectional study · 2026 · DOI

  • This finding warrants further investigation regarding cardiovascular risk stratification in this vulnerable population.

    Association between gut epithelial barrier biomarkers and LDL-cholesterol in HIV-infected individuals · 2026 · DOI

  • lead Future research could focus on revascularisation outcomes in age-matched prospective studies, addressing aspects such as socioeconomic factors, WIfI scores and post- discharge follow-up. Further research is required to better understand the challenges faced by PLHIV with CLTI.

    Human immunodeficiency virus in chronic limb-threatening ischaemia: Risk factors, management, and outcomes: A South African retrospective cohort study · 2026 · DOI

  • Future studies can explore the use of other machine learning algorithms in predicting HIV viral load stability and transformation. Future studies can investigate the application of the study's findings in clinical practice.

    Stability and Transformation Prediction of HIV Viral Load Using the Application of Machine Learning and Principal Component Algorithms · 2026 · DOI

  • The lack of effective predictive models for HIV patients is a significant problem. The current antiretroviral therapy medications have limitations in terms of efficacy and accessibility.

    Stability and Transformation Prediction of HIV Viral Load Using the Application of Machine Learning and Principal Component Algorithms · 2026 · DOI

  • There is a limited evidence on the prevalence and determinants of low perceived risk of hypertension among PLHIV in Uganda and similar sub-Saharan African settings. The study aims to address this gap by assessing the prevalence of low perceived risk of hypertension and its associated factors among adult PLHIV in Eastern Uganda.

    Prevalence and factors associated with low perceived risk of hypertension among adults living with HIV in Eastern Uganda · 2026 · DOI

  • The prevalence and associated factors of prediabetes among people living with HIV in sub-Saharan Africa are not well understood. There is a need for studies to investigate the prevalence and associated factors of prediabetes among people living with HIV in Zambia.

    Prevalence and associated factors of prediabetes among adults living with HIV receiving dolutegravir-based antiretroviral therapy in Zambia · 2026 · DOI

  • The study had a modest sample size, which limited the power to detect small-to-moderate associations. The study's findings should be interpreted cautiously due to the limited sample size and potential influential observations. The study did not apply formal multiple-comparison adjustment due to the exploratory nature of the correlations.

    Elevated high sensitivity cardiac troponin T among men with HIV who use stimulants: A cross-sectional study of subclinical cardiovascular injury · 2026 · DOI

  • The relationship between stimulant use and cardiovascular disease risk in people with HIV is not well understood. There is a need for further research on the effects of stimulant use on cardiovascular disease risk in people with HIV. The study aims to address this gap by investigating the relationship between stimulant use and high-sensitivity cardiac troponin T levels.

    Elevated high sensitivity cardiac troponin T among men with HIV who use stimulants: A cross-sectional study of subclinical cardiovascular injury · 2026 · DOI

  • The study aims to address the gap in understanding the relationship between HIV infection duration and left ventricular concentric remodeling and myocardial fibrosis.

    Association Between <scp>HIV</scp> Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross‐Sectional Study Using Cardiac <scp>MRI</scp> · 2026 · DOI

  • There is a need for reliable biomarkers to facilitate early identification and screening of cognitive impairment in people living with HIV. Prior studies have identified a gap in the understanding of the relationship between plasma biomarkers and cognitive impairment in this population.

    Plasma neurofilament light chain and Dickkopf-1 as biomarkers associated with cognitive impairment in people living with HIV: a case-control study · 2026 · DOI

  • Future studies can build on the findings of this study to further investigate the safety profile of biktarvy. Future research can explore the causal relationships between biktarvy and adverse events.

    Comparative safety profile of biktarvy: insights from a clinical cohort and the FAERS database · 2026 · DOI

  • There is a need for real-world evidence on the adverse events associated with biktarvy. The study addresses the gap in knowledge on the safety profile of biktarvy.

    Comparative safety profile of biktarvy: insights from a clinical cohort and the FAERS database · 2026 · DOI

  • The high drug-drug interaction potential of ritonavir and cobicistat boosting may necessitate dose adjustments or substitutions of concomitant medications. Gastrointestinal intolerance represents a leading cause of discontinuation in older patients. Metabolic effects, including dyslipidaemia and insulin resistance, may further compound the cardiovascular risk burden in this population.

    Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: a narrative review · 2026 · DOI

  • Further studies are needed to evaluate the long-term safety and efficacy of dual antiretroviral therapy in aging and comorbid people with HIV. Research should focus on developing strategies to minimize the risks associated with dual antiretroviral therapy, such as drug-drug interactions and gastrointestinal intolerance. Studies should investigate the impact of dual antiretroviral therapy on patient-reported outcomes and quality of life in this population.

    Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: a narrative review · 2026 · DOI

  • There is a need to assess the prevalence of lipid disorders and associated factors among people living with HIV in Cameroon. The study aims to fill the gap in knowledge on the relationship between ART duration and lipid disorders among PLHIV.

    Antiretroviral therapy and lipid disorders among people living with HIV/AIDS in the West Region of Cameroon: a comparative cross-sectional study · 2026 · DOI

  • There is a need to consider HIV as a potential cause of stroke in young patients. There is a lack of awareness about the diverse neurological manifestations of HIV.

    Lacunar Infarction as a Neurological Manifestation of Human Immunodeficiency Virus (HIV): A Case Report · 2026 · DOI

  • There is a lack of research on the relationship between Mediterranean diet adherence and systemic inflammation in people with HIV and PrEP users. Prior studies have focused on the general population or specific patient groups.

    Mediterranean diet adherence and systemic inflammation in people with HIV and PrEP users · 2026 · DOI

  • The study had a retrospective design, which may be subject to biases and limitations. The sample size was limited to 117 patients. The study relied on self-reported data, which may be subject to social desirability bias.

    Abandono da terapia antirretroviral e desafios de retenção em HIV: evidências sobre fatores psicossociais e implicações para a gestão em saúde em Maputo, Moçambique · 2026 · DOI

  • Future studies should investigate the effectiveness of interventions designed to address psychosocial factors and organizational issues. Research should explore the impact of patient-centered care on retention in ART. The study highlights the need for further research on the social and economic context of HIV patients in Mozambique.

    Abandono da terapia antirretroviral e desafios de retenção em HIV: evidências sobre fatores psicossociais e implicações para a gestão em saúde em Maputo, Moçambique · 2026 · DOI

  • Perinatally HIV-infected adolescents (PHIVA) experience many physical sequelae, but little is known about their levels of disability, fatigue or peripheral neuropathy.

    Disability, fatigue and peripheral neuropathy in adolescents with perinatal HIV infection · 2023 · DOI

  • What could not be determined was whether the automaticity problems found in this population were related to the neurocognitive functioning or neurodevelopmental delays which are known to exist in children with HIV/AIDS despite being on HAART, or if it was due to other factors.

    Investigation of saccadic eye movement abnormalities in children with HIV/AIDS on HAART · 2023 · DOI

  • Introduction Low bone mineral density (BMD) has been described as a non-AIDS-related event in human immunodeficiency virus (HIV)-patients, but it is poorly studied by dual-energy X-ray absorptiometry (DXA) and trabecular bone score (TBS) in young HIV-infected men who have received no previous antiretroviral treatment (ART).

    Trabecular bone score and 3D-DXA in young, antiretroviral treatment-naïve patients in Madrid · 2021 · DOI

  • Limited data are available about HIV or antiretroviral (ARV)-mediated mitochondrial damage in this population group, specifically, regarding oxygen consumption and apoptosis approach.

    Study of oxidative, enzymatic mitochondrial respiratory chain function and apoptosis in perinatally HIV-infected pediatric patients · 2013 · DOI

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46 open questions have been extracted from the limitations and future-work passages of 263 HIV-related health complications and treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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