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Open research questions in HIV/AIDS Impact and Responses

82 unresolved questions extracted from the limitations and future-work sections of 1,753 HIV/AIDS Impact and Responses papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Systemic fragmentation limits the program's effectiveness. Stigma and reliance on donor-funded initiatives are significant challenges. Limited outreach to high-risk groups and poor integration of services are also challenges.

    Evaluating Tuberculosis-human Immunodeficiency Virus Co-infection Strategies: A Qualitative Study From Semarang, Indonesia · 2026 · DOI

  • The study's sample size is limited to 20 participants. The study relies on self-reported data from participants, which may be subject to biases. The study's findings may not be generalizable to other contexts.

    Evaluating Tuberculosis-human Immunodeficiency Virus Co-infection Strategies: A Qualitative Study From Semarang, Indonesia · 2026 · DOI

  • Stigma and delayed diagnosis pose significant barriers to prevention efforts. Limited healthcare worker capacity and diagnostic limitations are challenges to TB preventive therapy.

    Initiation of Isoniazid Preventive Therapy in Under- Five Children: A Cross-Sectional Study in Zambia · 2026 · DOI

  • The study is limited by its cross-sectional design, which does not establish causality. The reliance on facility-based data may not capture broader community-level factors.

    Initiation of Isoniazid Preventive Therapy in Under- Five Children: A Cross-Sectional Study in Zambia · 2026 · DOI

  • Further studies should explore the impact of NGOs on the response to HIV. Research should investigate strategies to address funding crises and institutional disarticulation.

    Organizaciones no gubernamentales como mediadoras sociales en la respuesta al VIH en Santiago de Cali (2023-2025) · 2026 · DOI

  • The role of NGOs in the response to HIV is not well understood. There is a need to describe and characterize the participation of NGOs in the HIV response.

    Organizaciones no gubernamentales como mediadoras sociales en la respuesta al VIH en Santiago de Cali (2023-2025) · 2026 · DOI

  • The study identifies a gap in the understanding of HIV/AIDS prevention behavior among young people. The study highlights the need for further research on the relationships among information capacity, motivation, and behavioral skills in HIV/AIDS prevention.

    Kapasitas Informasi, Motivasi dan Keterampilan Berperilaku Kalangan Muda dalam Pencegahan HIV/AIDS · 2026 · DOI

  • Sustaining youth-friendly preventive services is a critical challenge in Africa, particularly in Nigeria. Nigeria faces one of the highest burdens of HIV among youth in West and Central Africa. There is limited youth engagement in the design and implementation of preventive services.

    A designathon to collaboratively develop sustainable HIV prevention services for youth with community-based organizations in Nigeria · 2026 · DOI

  • The study identifies a gap in the engagement of youth in the design of services that promote and increase the uptake of essential services to reduce HIV and other sexually transmitted infections. The study identifies a gap in the development of sustainable HIV prevention services for youth in Nigeria.

    A designathon to collaboratively develop sustainable HIV prevention services for youth with community-based organizations in Nigeria · 2026 · DOI

  • There is a lack of understanding about the relationship between neighborhood social vulnerability, social support, and physical activity in older people with HIV. Larger studies using more precise measures of structural factors are needed to better understand this relationship.

    Aging with HIV: The Interplay of Neighborhood-Level Social Vulnerability, Social Support, and Physical Activity · 2026 · DOI

  • The study identifies a gap in the protection of sexual autonomy for vulnerable women. The COVID-19 pandemic highlighted the need for intervention programs for vulnerable populations.

    Are internal migrants (head porters) sexually vulnerable due to the coronavirus pandemic? A qualitative study of the situation in Ghana · 2025 · DOI

  • This paper argues that these conflicting findings could reflect a temporal shift in the education-HIV gradient, rather than errors in epidemiological data.

    Revisiting the education-HIV gradient in Africa: Cohort variation analysis of a temporal shift and speculation on causes · 2025 · DOI

  • While a negative relationship between education and morbidity is generally well-established, conflicting reports on the education-HIV gradient in Africa raised doubts about its consistency.

    Revisiting the education-HIV gradient in Africa: Cohort variation analysis of a temporal shift and speculation on causes · 2025 · DOI

  • Field research study of HIV/AIDS action in Uganda contributes unexpected insights regarding collaborative governance in an institution context under-explored in public administration and organization studies, the developing non-democracy.

    Collaborative Governance in a Developing Non-Democracy: Uganda's Organizational Success Fighting HIV/AIDS · 2021 · DOI

  • Orphans and vulnerable children (OVC) programs in high HIV prevalence contexts are shifting toward ‘graduation’ approaches to facilitate outcome-focused programming, but little is known about the sustainability of participant outcomes post-graduation.

    Realistic expectations: exploring the sustainability of graduation outcomes in a program for children affected by HIV in Kenya’s Northern Arid Lands · 2020 · DOI

  • </ns5:p> <ns5:p> <ns5:bold>Results:</ns5:bold> Of the 314 documents analysed, 35 mention language or translation, but the majority of the mentions are made in passing or in the context of providing background socio-cultural information, the implications of which are not explored.

    Multilingualism and strategic planning for HIV/AIDS-related health care and communication · 2019 · DOI

  • Little is known about the impact of HIV/AIDS on people who acquired the virus through former commercial plasma donations in the mid-1990s in rural Central China.

    Impacts of HIV/AIDS on poor and socially marginalised former commercial plasma donors in rural central China: social work implications · 2017 · DOI

  • Future research should investigate the roles and interactions of different types and sources of support, specifically as they relate to interventions aiming to ameliorate the experiences of youth newly diagnosed with HIV.

    “When we are together I feel at home.” Types and sources of social support among youth newly diagnosed with HIV in Kenya: implications for intervention · 2015 · DOI

  • In so doing, it also examines a central tension within human rights discourse, namely between the construal of rights as shared and universally applicable to all human beings, while being created in and limited by the location in which they were elaborated, as well as by the language used to formulate them.

    The unfinished nature of rights-informed HIV- and AIDS-related education: an analysis of three school-based initiatives · 2014 · DOI

  • Thus, in a country where resources are scarce and where early intervention starts too late and ends too early for most children, it is vital that protective factors at various levels of the ecology be mobilized at the earliest opportunity to prevent the accumulation of risk factors as well as balance inequalities where risks are already established.

    Early Childhood Intervention in South Africa in Relation to the Developmental Systems Model · 2012 · DOI

  • BACKGROUND: Intergenerational transfer patterns in sub-Saharan Africa are poorly understood, despite the alleged importance of support networks to ameliorate the complex implications of the HIV/AIDS epidemic for families.

    Intergenerational Transfers in the Era of HIV/AIDS: Evidence from Rural Malawi · 2012 · DOI

  • Understanding of the effects of formal education on HIV/AIDS infection in South Saharan Africa (SSA) has been a complex task because consecutive waves of research offer different, seemingly contradictory results and explanations of what exactly are the schooling effects on HIV/AIDS and the causal mechanisms driving those effects.

    Multiple Effects of Education on Disease: The Intriguing Case of HIV/AIDS in Sub-Saharan Africa · 2012 · DOI

  • Since empirical evidence on the socioeconomic impact of HIV/AIDS on households with older persons is lacking, this paper attempts to fill this gap, using data from a household-based survey conducted in Bhambayi, a mixed formal and informal settlement north of eThekwini, KwaZulu-Natal.

    Poverty, HIV/AIDS and the old age pension in Bhambayi, Kwazulu-Natal, South Africa · 2011 · DOI

  • HIV/AIDS has been mentioned in this literature as a biosecurity issue, but despite its importance as a major global health problem, the ways in which HIV/AIDS might be considered a matter of biosecurity have not been explored in depth.

    Biosecurity and the international response to HIV/AIDS: governmentality, globalisation and security · 2009 · DOI

  • Few studies have considered how the HIV epidemic's outcomes are interacting with other societal processes, such as globalisation and urbanisation, or how these processes collectively converge with place-specific conditions to expose, drive and compound vulnerabilities to HIV and AIDS.

    The making of vulnerabilities: understanding the differentiated effects of HIV and AIDS among street traders in Warwick Junction, Durban, South Africa · 2007 · DOI

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82 open questions have been extracted from the limitations and future-work passages of 1,753 HIV/AIDS Impact and Responses papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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