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Open research questions in Infectious Diseases and Tuberculosis

56 unresolved questions extracted from the limitations and future-work sections of 235 Infectious Diseases and Tuberculosis papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The disease often presents with nonspecific clinical manifestations, leading to delayed diagnosis. Foot and ankle involvement in osteoarticular tuberculosis is extremely rare.

    A Rare Presentation of Osteoarticular Tuberculosis in a Child with Chronic Foot Swelling: A Case Report · 2026 · DOI

  • Delayed diagnosis and poor immunization status continue to adversely affect outcomes. Malnutrition is a significant challenge in managing tuberculous meningoencephalitis. Limited access to healthcare and poor nutritional status are challenges in developing countries.

    Clinical profile of tuberculous meningoencephalitis in pediatric patients at a tertiary care center · 2026 · DOI

  • Spinal tuberculosis is a complex disease that requires proper surgical management. The disease can lead to significant morbidity and mortality if left untreated or improperly managed. The study highlights the challenges of managing spinal tuberculosis, including the need for proper surgical techniques.

    Surgical Management and Clinical Outcomes of Spinal Tuberculosis: A Systematic Review and Meta-analysis on Current Concepts and Strategies · 2026 · DOI

  • The insidious onset and non-specific clinical manifestations of STB frequently lead to diagnostic delays. Traditional diagnostic methods have limitations. There is a need for more effective diagnostic strategies for spinal diseases.

    LASSO regression-based machine learning model for differentiating spinal tuberculosis, pyogenic spondylitis, and endplate osteochondritis: development and clinical application · 2026 · DOI

  • The need for more effective and efficient diagnostic methods for tuberculosis. The high costs and infrastructure requirements for some new methods. The need for standardization of new methods.

    Tuberkuliozės diagnostikos ir gydymo naujienos · 2026 · DOI

  • The nonspecific presentation of sacroiliitis and iliopsoas abscess. The need for early recognition and prompt management to prevent morbidity and mortality.

    <b>ILIOPSOAS ABSCESS SECONDARY TO PYELONEPHRITIS WITH SUBSEQUENT UNILATERAL SACROILIITIS PRESENTING AS LOW BACK PAIN IN A YOUNG ADULT: A CASE REPORT</b> · 2026 · DOI

  • Nonspecific clinical features of orbital tuberculosis. Difficulty in diagnosing orbital tuberculosis due to its rarity. Need for early biopsy and histopathological confirmation.

    Orbital Tuberculosis Mimicking a Malignant Tumor: A Case Report · 2026 · DOI

  • Tuberculous mediastinal lymphadenopathy is a rare cause of vocal cord paralysis. There is a need to raise awareness about this potential cause of vocal cord paralysis.

    Tuberculous mediastinal lymphadenopathy can cause left vocal cord paralysis. · 1983 · DOI

  • Delayed diagnosis and limited access to advanced microbiological testing. Barriers to long-term follow-up. Limited resources in low-and middle-income countries.

    Epidemiological and clinical review of spinal Tuberculosis at a Regional Orthopaedic Hospital in Nigeria · 2026 · DOI

  • The study was conducted at a single centre. The sample size was limited to 223 patients.

    Epidemiological and clinical review of spinal Tuberculosis at a Regional Orthopaedic Hospital in Nigeria · 2026 · DOI

  • The interval between initial symptom onset and diagnosis of foot and ankle TB varies widely across studies; reports have described delays exceeding one year, consistent 894 Volume 06 Issue 05 May 2026 Corresponding Author: Brigita Ficellia Maria…

    A Rare Presentation of Osteoarticular Tuberculosis in a Child with Chronic Foot Swelling: A Case Report · 2026 · DOI

  • There is a need to improve outcomes in childhood tuberculous meningoencephalitis. The impact of BCG vaccination and nutritional status on disease severity and outcomes is not well understood.

    Clinical profile of tuberculous meningoencephalitis in pediatric patients at a tertiary care center · 2026 · DOI

  • La meningitis tuberculosa, significa un reto hoy en día difícil de diagnosticar y de tratar. La tuberculosis meníngea es una enfermedad que afecta a los niños en menor proporción.

    Tuberculosis meníngea en pediatría: Reporte de un caso · 2026 · DOI

  • The case highlights the difficulties faced in diagnosing TBM in children, particularly in resource-limited settings. Delays in diagnosis and treatment can lead to severe consequences. The availability of diagnostic tools and healthcare infrastructure is limited in some settings.

    Paediatric Tuberculous Meningitis Supported by Stool-Based GeneXpert and Complementary Radiologic Findings in Somalia: A Case Report · 2026 · DOI

  • The difficulty in obtaining appropriate respiratory specimens in children, particularly in younger children who are unable to expectorate sputum. The need for non-invasive and easily obtainable diagnostic specimens to improve case detection and clinical outcomes.

    Paediatric Tuberculous Meningitis Supported by Stool-Based GeneXpert and Complementary Radiologic Findings in Somalia: A Case Report · 2026 · DOI

  • The study identifies a gap in the current understanding of the effectiveness of different surgical approaches in managing spinal tuberculosis. The study highlights the need for a comprehensive review of current concepts and strategies in the surgical management of spinal tuberculosis.

    Surgical Management and Clinical Outcomes of Spinal Tuberculosis: A Systematic Review and Meta-analysis on Current Concepts and Strategies · 2026 · DOI

  • There is a lack of awareness of osteoarticular tuberculosis as a possible cause of chronic ankle pain and swelling in children. The diagnosis of osteoarticular tuberculosis can be delayed due to its non-specific clinical presentation and imaging features that closely mimic other conditions.

    Diagnostic pitfalls in the imaging of talar aseptic osteonecrosis in children: Osteoarticular tuberculosis mimicking avascular necrosis of the talus: A case report · 2026 · DOI

  • Accurate differentiation of spinal tuberculosis, pyogenic spondylitis, and endplate osteochondritis remains a clinical challenge. Traditional diagnostic methods have limitations, and there is a need for more effective diagnostic strategies.

    LASSO regression-based machine learning model for differentiating spinal tuberculosis, pyogenic spondylitis, and endplate osteochondritis: development and clinical application · 2026 · DOI

  • Tuberculosis of bones and joints, especially the spine, is often detected in an advanced stage. There is a need for a differentiated approach to the diagnosis and treatment of vertebral destructions.

    Differentiated approach to the diagnosis and treatment of the vertebral destructions · 2026 · DOI

  • The need for more effective and efficient diagnostic methods for tuberculosis. The need for more research on the use of artificial intelligence in tuberculosis diagnosis.

    Tuberkuliozės diagnostikos ir gydymo naujienos · 2026 · DOI

  • There is a lack of awareness about the possibility of M.caprae causing human disease. There is a need for increased recognition of intestinal tuberculosis as a potential cause of chronic abdominal pain, diarrhea, and weight loss.

    Mycobacterium caprae Nedeniyle Gelişen ve Karsinomla Karışan Çekum Tüberkülozu: Bir Olgu Sunumu ve Literatür İncelemesi · 2026 · DOI

  • The diagnosis of mycobacterial meningoradiculitis can be challenging due to negative microbiological tests. There is a need for effective treatment options for patients with mycobacterial meningoradiculitis.

    Hypertrophic cauda equina syndrome in mycobacterial meningoradiculitis · 2026 · DOI

  • There is a lack of reports documenting the progression of pyelonephritis to iliopsoas abscess and sacroiliitis. The exact pathogenetic mechanism linking the initial pyelonephritis and the subsequent development of MRSA iliopsoas abscess and sacroiliitis is not well understood.

    <b>ILIOPSOAS ABSCESS SECONDARY TO PYELONEPHRITIS WITH SUBSEQUENT UNILATERAL SACROILIITIS PRESENTING AS LOW BACK PAIN IN A YOUNG ADULT: A CASE REPORT</b> · 2026 · DOI

  • The study had a limited sample size of 87 patients. The study was retrospective in design. The study did not investigate the long-term outcomes of patients with these complications.

    Proliferative Arachnoiditis and Vasculitis in Central Nervous System Tuberculosis: A Retrospective Analysis of Clinical Features and Outcomes from a Tertiary Centre in India · 2026 · DOI

  • There is a lack of understanding of the clinical spectrum and outcomes of patients with TB arachnoiditis and TB-associated CNS vasculitis. The study aims to address this gap by characterizing the clinical details, follow-up records, and outcomes of patients with these complications.

    Proliferative Arachnoiditis and Vasculitis in Central Nervous System Tuberculosis: A Retrospective Analysis of Clinical Features and Outcomes from a Tertiary Centre in India · 2026 · DOI

Most-cited papers in Infectious Diseases and Tuberculosis

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56 open questions have been extracted from the limitations and future-work passages of 235 Infectious Diseases and Tuberculosis papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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