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Open research questions in Inflammasome and immune disorders

349 unresolved questions extracted from the limitations and future-work sections of 761 Inflammasome and immune disorders papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Future studies using single-cell and spatiotemporal approaches will be essential for determining how signaling dynamics shape inflammasome outcomes during infection

    The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death · 2026 · DOI

  • Addressing the three critical questions for evaluating the translational potential of targeting the mitochondrial autophagy-macrophage crosstalk network, - Investigating the role of mitochondrial autophagy-macrophage crosstalk in CVD

    Mitophagy–pyroptosis–macrophage polarization crosstalk in cardiovascular diseases: mechanistic insights and therapeutic potential · 2026 · DOI

  • Small sample size of 38 children, - Exclusion of T homozygosity from subsequent analyses to preserve statistical integrity, - Lack of long-term follow-up data

    Candidate Stress-Specific microRNA Expression in Pediatric Thrombosis and Healthy Children: A Comparative Analysis of Serum miR-34a-5p in Relation to Stress Levels and Inflammatory Genetic Traits · 2026 · DOI

  • Further investigation of the link between PT and stress-induced inflammation, - Examination of the role of miR-34a-5p in regulating IL1B expression, - Study of the effects of different genotypes on the circulating levels of IL-1β

    Candidate Stress-Specific microRNA Expression in Pediatric Thrombosis and Healthy Children: A Comparative Analysis of Serum miR-34a-5p in Relation to Stress Levels and Inflammatory Genetic Traits · 2026 · DOI

  • The asymptomatic early phase and unpredictable progression of Stroke-Heart Syndrome make it a critical determinant of poor prognosis and mortality in patients with acute neurological injuries. The complexity of the NF-κB/NLRP3 pathway and its role in cardiac vascular endothelial injury after ischemic stroke. The need to develop effective therapeutic strategies to prevent recurrent cardiac vascular events post-ischemic stroke.

    NF-κB aggravates cardiac vascular endothelial injury by sustained activation of the NLRP3 inflammasome after ischemic stroke in rats · 2026 · DOI

  • Further research is needed to understand the mechanisms of pyroptosis in POI, - Investigation of the role of pyroptosis in other programmed cell death pathways, including apoptosis, ferroptosis, and autophagy, - Development of precise, non-hormonal therapeutic interventions to rescue the ovarian reserve and protect female reproductive health

    Pyroptosis in premature ovarian insufficiency: pathogenic mechanisms, pathway crosstalk, and therapeutic strategies · 2026 · DOI

  • The current understanding of POI pathogenesis is incomplete. The role of pyroptosis in POI is not fully understood. New therapeutic strategies are needed to target POI.

    Pyroptosis in premature ovarian insufficiency: pathogenic mechanisms, pathway crosstalk, and therapeutic strategies · 2026 · DOI

  • the need for optimizing dapansutrile's delivery, particularly to the central nervous system - the requirement for further research to fully understand dapansutrile's mechanisms and therapeutic applications - the potential for drug-drug interactions in combination therapy

    Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives · 2025 · DOI

  • The need for novel anti-inflammatory strategies due to the limitations of currently available drugs. The potential of dapansutrile in mitigating various inflammatory diseases, including gouty arthritis, cardiovascular diseases, and neurodegenerative disorders.

    Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives · 2025 · DOI

  • The mechanism of action of ECG against sepsis-induced ALI remains unexplored. The potential of dietary or natural compounds to modulate the PANoptosis pathway in sepsis-induced ALI is largely unexplored.

    Protective effects of Exocarpium Citri Grandis against sepsis-induced acute lung injury via PANoptosis inhibition · 2025 · DOI

  • Macrophage pyroptosis increases the risk of atherosclerosis plaque rupture. Current pharmacological treatments and surgical interventions have significant limitations, such as liver damage and bleeding, and restenosis. The optimal concentration of kaempferol to be used in the experiments needs to be determined.

    Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway · 2025 · DOI

  • Explore new treatments for atherosclerosis, - Innovations that improve treatment outcomes, enhance patient compliance, and improve prognosis would be particularly valuable

    Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway · 2025 · DOI

  • The exact role of autophagy in Graves disease is not well explained. The relationship between autophagy and the pathogenesis of Graves disease is not fully understood. The protective and harmful effects of autophagy in Graves disease need to be clarified.

    The role of autophagy in Graves disease: knowns and unknowns · 2025 · DOI

  • investigate the underlying mechanisms of GSDME in radiation-induced hematopoietic injury, - explore the potential therapeutic applications of GSDME knockout or inhibition in the treatment of radiation-induced BM injury, - study the effects of GSDME knockout on other types of hematopoietic cells

    GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation · 2025 · DOI

  • The underlying mechanisms of vitamin D's association with the pathogenesis of inflammatory bowel disease are not yet fully understood. The study aims to investigate the effect of vitamin D on dextran sodium sulfate-induced colitis in mice, a gap in current research.

    Vitamin D Modified DSS-Induced Colitis in Mice via STING Signaling Pathway · 2025 · DOI

  • Investigate the effects of the flavonoids in vivo, - Examine the potential of other bioactive molecules in modulating the NLRP3 inflammasome, - Study the synergistic effects of combining different flavonoids

    Euterpe oleracea Mart. Bioactive Molecules: Promising Agents to Modulate the NLRP3 Inflammasome · 2024 · DOI

  • DDX3X (DEAD box helicase 3, X linked) is a common and essential component for both stress granules and NLRP3 inflammasome assembly and their activation; however, the upstream cellular stress signals driving DDX3X to activate the contrasting cellular pathway remain unclear.

    E3 ubiquitin ligase SYVN1 mediates K63-linked ubiquitination of DDX3X to activate Macrophage NLRP3 Inflammasome · 2026 · DOI

  • However, the recruitment of caspase-1 into the ASC speck for activation remains unclear.

    Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation · 2026 · DOI

  • However, the host and viral determinants that contribute to PHEV-induced brain injury remain incompletely defined.

    Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation · 2026 · DOI

  • ABSTRACT Neurotropic coronaviruses can invade the central nervous system (CNS) and cause severe neurological disease, but the mechanisms underlying virus-induced neuroinflammation remain incompletely understood.

    Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation · 2026 · DOI

  • While some caspase‐1 sensing and inhibition studies have been reported, the use of DHPs for these applications remains unexplored.

    Potent Caspase‐1 Antagonists From Dihydropyridine Derivatives: In Vitro Fluorescence Assays and Cell Imaging · 2026 · DOI

  • Introduction Ischemic stroke elevates the risk of recurrent vascular events via endothelial cell activation-driven systemic inflammation, yet the existence and mechanisms of stroke-induced sustained pro-inflammatory changes in cardiac vascular endothelial cells remain unclear.

    NF-κB aggravates cardiac vascular endothelial injury by sustained activation of the NLRP3 inflammasome after ischemic stroke in rats · 2026 · DOI

  • Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood.

    Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection · 2026 · DOI

  • NLR-family CARD domain-containing protein 4 ( NLRC4 ), a cytosolic inflammasome component driving IL-1β-mediated inflammation, is linked to autoinflammatory syndromes via germline gain-of-function mutations, though its role in term infant NEC remains underexplored.

    Autoinflammation with infantile enterocolitis induced by a heterozygous variant (c.1357C > T) in the NLRC4 gene: a case report · 2026 · DOI

  • However, the crosstalk between PCD, metabolic reprogramming, and immune heterogeneity remains poorly understood.

    Systematic analysis of programmed cell death–related genes in sepsis reveals immune heterogeneity and enables patient stratification · 2026 · DOI

Most-cited papers in Inflammasome and immune disorders

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349 open questions have been extracted from the limitations and future-work passages of 761 Inflammasome and immune disorders papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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