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Open research questions in Intraocular Surgery and Lenses

82 gap statements mined from Intraocular Surgery and Lenses papers in our 4.5M-paper local library, which holds 523 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Currently, there is insufficient evidence to conclude that penetrating FSLACS-AK provides a significantly greater astigmatic correction than intrastromal FSLAK.

    Femtosecond laser assisted phacoemulsification plus IOL implant: toric IOL vs. astigmatic keratotomy · 2026 · DOI

  • There is a need for a simpler and more efficient approach to managing capsular instability in cataract surgery. The Cionni-modified capsular tension ring may not always be readily available, particularly in resource-limited settings.

    Sulcus fixation of a standard capsular tension ring in cataract surgery with capsular instability · 2026 · DOI

  • There is a gap in the number of trained ophthalmologists. The study aims to address this gap by analyzing the attitudes and interests of undergraduate medical students towards ophthalmology as a career choice.

    Evaluating Student Attitude towards Careers in Ophthalmology as a Medical Option Southern India · 2026 · DOI

  • Balancing the need for clear visualization with the risk of elevated IOP.

    Active fluidics at lower intraocular pressure reduces intraoperative discomfort during phacoemulsification: a propensity score-matched cohort study · 2026 · DOI

  • Predicting CE occurrence in patients with preoperatively normal endothelia remains challenging. Traditional methods like logistic regression have limitations in integrating multidimensional clinical data and optimizing prediction accuracy.

    Machine learning for risk stratification of postoperative corneal edema in East Asian cataract patients: a model for precision ophthalmology · 2026 · DOI

  • The need to identify preoperative and intraoperative predictors of endothelial cell loss. The importance of clarifying which baseline characteristics and intraoperative parameters are associated with early postoperative CD decline.

    Endothelial Cell Loss After Phacoemulsification in a Romanian Cohort: Early Outcomes and Associated Risk Factors · 2026 · DOI

  • There is a need for a technique that can prevent PCO and other complications after IOL implantation. The current techniques for IOL implantation have limitations and risks. There is a need for a comprehensive review of the BIL implantation technique.

    Bag-in-the-lens technique · 2026 · DOI

  • The lack of a standardized dataset for skill assessment in cataract surgery using deep learning models. The need for a comprehensive benchmark for surgical video analysis.

    Cataract-LMM Large-Scale Multi-Source Multi-Task Benchmark for Deep Learning in Surgical Video Analysis · 2026 · DOI

  • In paediatric patients, the ability to report these symptoms may be limited and their impact on visual development is not fully characterised. The use of multifocal IOLs in pediatric cataract surgery remains controversial but is gaining attention in selected cases. Neuroadaptation in children may proceed more effectively than in adults, but the timeline remains uncertain.

    Trifocal Intraocular Lens Implantation in Pediatric Traumatic Cataract: Functional Recovery Including Stereopsis · 2026 · DOI

  • The study aims to determine the accuracy of biometric calculations in patients after cataract surgery at Waled Regional General Hospital, Cirebon in 2022, which has not been previously studied.

    The Accuracy of Biometrics on Patients After Cataract Surgery in The Ophtalmic Ward of Waled Regional Public Hospital in Year 2022 · 2026 · DOI

  • Clinical trials are needed to evaluate the new approach in a real-world setting. Comparison to other methods is necessary to determine the most accurate approach. Further development of the sigmoidal effective lens position prediction function may be necessary.

    Intraocular Lens Calculation Concept Based on Aphakic Refraction—Considerations on a Cornea Model With Two Refracting Surfaces · 2026 · DOI

  • There is a need for a new approach to intraocular lens power calculation that does not rely on biometric data. Existing methods have limitations and may not be accurate in all cases. A method based on aphakic refraction could fill this gap.

    Intraocular Lens Calculation Concept Based on Aphakic Refraction—Considerations on a Cornea Model With Two Refracting Surfaces · 2026 · DOI

  • To our knowledge, the specific combination of all three haptics synechiated to the iris stroma, pre-existing superior iridodialysis, posterior migration of the air bubble and ultimately successful graft adherence without rebubbling has not been previously reported. Cases of successful DSAEK without sustained tamponade are rarely reported.

    Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) for Pseudophakic Bullous Keratopathy Secondary to a Retained Baikoff Anterior Chamber IOL with Synechiated Haptics and Traumatic Iridodialysis: A Case Report · 2026 · DOI

  • Posterior intravitreal BSS injection provides an effective method to stabilize the iris–lens diaphragm and maintain AC architecture during endothelial keratoplasty when conventional air/gas injection alone is insufficient.

    Posterior Segment Pressurization With Intravitreal Balanced Salt Solution to Stabilize Anterior Chamber Gas During Endothelial Keratoplasty · 2026 · DOI

  • There is a lack of studies evaluating the changes in corneal densitometry after Nd:YAG laser posterior capsulotomy. The effects of Nd:YAG laser posterior capsulotomy on corneal optical aberrations and best-corrected visual acuity are not well understood.

    Localized Peripheral Corneal Densitometry Changes at 1 Month After Laser Posterior Capsulotomy · 2026 · DOI

  • There is a need to understand the magnitude and predictors of changes in corneal endothelial cells and Central Corneal Thickness after phacoemulsification. Prior work has shown that phacoemulsification is associated with risks to intraocular structures, but the mechanisms and predictors of these changes are not well understood.

    Comparative Analysis of Pre- and Post-Operative Central Corneal Thickness and Corneal Endothelial Cell Density in Uneventful Phacoemulsification: A Cross-Sectional Study · 2026 · DOI

  • There is a need for comparative studies on the clinical outcomes of different OVDs. The existing literature on the use of OVDs in cataract surgery is limited. There is a gap in the understanding of the performance and safety of different OVDs during cataract surgery.

    Comparative Clinical Outcomes of a 1.0% Versus 1.4% Sodium Hyaluronate OVD in Cataract Surgery: A Prospective Study · 2026 · DOI

  • There is a lack of knowledge about the potential applicability of MRH in performing successful phacoemulsification and IOL implantation procedures. There is a need to validate innovative systems in cataract surgery. The traditional ophthalmic surgery model has limitations in terms of ergonomics and educational value.

    Phacoemulsification surgery: stepping into the mixed reality era · 2026 · DOI

  • The study had a relatively small sample size. The follow-up period was limited to 1 month. Surgeons and patients could not be masked due to the nature of the intervention.

    Active fluidics at lower intraocular pressure reduces intraoperative discomfort during phacoemulsification: a propensity score-matched cohort study · 2026 · DOI

  • These previous analyses, which utilised Scheimpflug imaging to quantify fluid reservoir debris, were limited to a single central point along one corneal meridian between the posterior scleral lens surface and anterior cornea using the instrument software.

    Scleral Lens Fenestrations and Fluid Reservoir Debris · 2026 · DOI

  • Diverse benchmarking formulations by future researchers, such as regression on continuous scores, multi-class skill categorization, and objective assessment using motion-derived kinematic…

    Cataract-LMM Large-Scale Multi-Source Multi-Task Benchmark for Deep Learning in Surgical Video Analysis · 2026 · DOI

  • The primary negative systematic review has methodological boundaries, - Limited volume of controlled clinical evidence, - Incomplete reporting in some…

    Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice · 2026 · DOI

  • Small closed dataset; no independent/ external validation; ROI pre-defined by the iridology chart (circularity); authors note misclassification of operated and well-controlled cases and possible reporting…

    Iridology: Biological plausibility, clinical evidence, and implications for ophthalmic practice · 2026 · DOI

  • Confirm these findings with larger cohorts, - Explore additional risk factors for VF progression, - Investigate the effects of smoking cessation on VF…

    Risk factors for Visual Field Progression in patients with Adequate Intraocular Pressure Reduction after Ahmed valve implantation · 2026 · DOI

  • Despite achieving adequate intraocular pressure control, some patients continue to experience visual field progression. The current study aims to fill this gap by identifying risk factors for visual field progression in glaucoma patients after Ahmed valve implantation.

    Risk factors for Visual Field Progression in patients with Adequate Intraocular Pressure Reduction after Ahmed valve implantation · 2026 · DOI

Most-cited papers in Intraocular Surgery and Lenses

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Open questions raised by papers listed on this page include: (1) There is a need for a simpler and more efficient approach to managing capsular instability in cataract surgery (“Sulcus fixation of a standard capsular tension ring in cataract surgery with…”, 2026); (2) There is a need for a technique that can prevent PCO and other complications after IOL implantation (“Bag-in-the-lens technique”, 2026); (3) The lack of a standardized dataset for skill assessment in cataract surgery using deep learning models (“Cataract-LMM Large-Scale Multi-Source Multi-Task Benchmark for Deep Learning in…”, 2026); (4) In paediatric patients, the ability to report these symptoms may be limited and their impact on visual development is not fully characterised (“Trifocal Intraocular Lens Implantation in Pediatric Traumatic Cataract:…”, 2026); (5) Clinical trials are needed to evaluate the new approach in a real-world setting (“Intraocular Lens Calculation Concept Based on Aphakic Refraction—Considerations…”, 2026). 82 gap statements have been mined from Intraocular Surgery and Lenses papers in our 4.5M-paper local library, which holds 523 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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