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Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Lipid metabolism and biosynthesis

121 unresolved questions extracted from the limitations and future-work sections of 296 Lipid metabolism and biosynthesis papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • further investigation into the potential biological and clinical relevance of perilipin 1, ATGL, and HSL in BC, - investigation into tumor–adipocyte interactions in BC

    Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features · 2026 · DOI

  • Further research into the function of palmitic acid in diverse pathological conditions - Investigation into the potential therapeutic strategies to prevent PA-induced lipotoxicity in ß cells - Study of the effects of natural antioxidants on PA-induced lipotoxicity

    Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases · 2025 · DOI

  • The gap in the current understanding of the mechanisms of palmitic acid-induced lipotoxicity. The need for effective therapeutic strategies to prevent palmitic acid-induced lipotoxicity. The lack of understanding of the interaction between different dietary fats and cellular outcomes.

    Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases · 2025 · DOI

  • The complex genetic basis of fatty acid composition variation in camelina. The need to account for population structure in the diversity panel to avoid false positives in GWAS. The challenge of identifying genetic loci associated with fatty acid composition in camelina seed oil using a GWAS approach.

    Genomic Analysis of the Natural Variation of Fatty Acid Composition in Seed Oils of Camelina sativa · 2025 · DOI

  • The study only used one type of marker, - The population structure may be skewed if only one type of marker is used, - The study was limited to four geographical locations

    Genomic Analysis of the Natural Variation of Fatty Acid Composition in Seed Oils of Camelina sativa · 2025 · DOI

  • further investigation is required to understand the detailed mechanisms involved in lipophagy, - studies are needed to explore the potential strategies to improve NAFLD, - research should investigate the activation of lipophagy programs in different cell types within hepatic tissues

    Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease · 2024 · DOI

  • There is a lack of understanding of the exact mechanisms of exercise in preventing and improving NAFLD. The detailed molecular mechanisms underlying the effects of exercise on lipophagy and liver lipid turnover are not yet fully understood. The paper aims to address this gap by exploring the potential of lipophagy-mediated exercise intervention in improving NAFLD.

    Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease · 2024 · DOI

  • The dynamic membrane lipid alterations in mosses remain unexplored. The evolutionary success and resilience of bryophytes to various stressors is in part attributed to their unique lipid components, but the details are not well understood.

    Dynamic Membrane Lipid Changes in Physcomitrium patens Reveal Developmental and Environmental Adaptations · 2024 · DOI

  • despite the exploratory nature of this study, - limited sample size for certain findings

    Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features · 2026 · DOI

  • While a large number of transcription factors (TFs) are involved in these transcriptional networks, in vivo investigation on how TF interaction dynamics affect transcriptional regulation in seed-to-seedling transition is lacking.

    ABSCISIC ACID INSENSITIVE 5 fine-tunes expression of lipid body genes through modulating ABSCISIC ACID INSENSITIVE 3 binding strength · 2026 · DOI

  • Notwithstanding, not much is known on ABI5's significance on ABI3's binding towards CREs.

    ABSCISIC ACID INSENSITIVE 5 fine-tunes expression of lipid body genes through modulating ABSCISIC ACID INSENSITIVE 3 binding strength · 2026 · DOI

  • The mechanism of this interaction and its consequences for cancer aggressiveness remains unexplored.

    The innate immune mediator group IIA secreted phospholipase A2 modulates lipid droplet formation in prostate cancer cells · 2026 · DOI

  • However, the genetic and lineage-specific regulation of their biogenesis and utilization remains poorly understood.

    Strain- and lineage-specific regulation of lipid droplet metabolism in the mouse blastocyst · 2026 · DOI

  • The immune microenvironment in ascites remains understudied, leaving the mechanism of ascites‐mediated abdominal metastasis obscure.

    PLIN2 Promotes Lipid Accumulation in Ascites‐Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling · 2025 · DOI

  • The potential interplay between matrix stiffness and hepatocyte lipid accumulation during NAFLD has not been established.

    Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease · 2025 · DOI

  • There is limited knowledge of the dynamic changes in the lipidome of rice during germination and the corresponding genes associated with the antioxidant and anti-cancerous properties of lipophilic fractions of pigmented rice sprouts (PRS).

    Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts · 2025 · DOI

  • The mechanism underlying oil synthesis in oil plant fruits remains elusive, as sugar metabolism provides the essential carbon skeleton without a clear understanding of its intricate workings.

    Regulatory mechanism of carbohydrate metabolism pathways on oil biosynthesis of oil plant Symplocos paniculata · 2025 · DOI

  • However, the dynamic behavior and response mechanisms of lipids during the germination of aged oat seeds remain unclear.

    Lipid remodeling and response mechanisms during the germination of aged oat seeds · 2025 · DOI

  • However, there is limited information on the fatty acid composition across different cultivars, developmental stages, and curing methods.

    Metabolomic and transcriptomic analyses reveal differences in fatty acids in tobacco leaves across cultivars and developmental stages · 2025 · DOI

  • However, the change of lipid profile at different ripening stages remain unclear.

    Analysis of lipidomics profile of Brassica napus hybrid ‘Fangyou 777’ and its parents during ripening stages based on UPLC-MS/MS · 2025 · DOI

  • Currently, the metabolic requirements of mast cell activation are poorly understood.

    Characterizing the regulatory role of diacylglycerol acyltransferase 2 (DGAT2) in IgE-activated mast cells 4362 · 2025 · DOI

  • While the host pathways Coxiella targets remain unknown, we have shown that it manipulates alveolar macrophage lipid storage organelles, called lipid droplets (LDs).

    Decoding Coxiella burnetii’s immune evasion strategy: Host lipid droplets, prostaglandin E2 and PPARs 3857 · 2025 · DOI

  • However, the number and characteristics of Sec14 homologous genes in soybean, as well as their potential roles, remain understudied.

    Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) · 2025 · DOI

  • Finally, this review addresses gaps in the literature that can be addressed to further the understanding of the role that the AHR has in the ovary and how its role can be leveraged in the clinic.

    The role of the aryl hydrocarbon receptor in ovarian development, function, xenobiotic metabolism, and disease · 2025 · DOI

  • The molecular mechanisms underlying lipid droplet biogenesis and degradation, however, are not well understood.

    Spartin-mediated lipid transfer facilitates lipid droplet turnover · 2024 · DOI

Most-cited papers in Lipid metabolism and biosynthesis

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121 open questions have been extracted from the limitations and future-work passages of 296 Lipid metabolism and biosynthesis papers in our 4.5M-paper local library. Each one below links back to the study that raised it, so you can read the original claim in context.

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